Alexey Dementiev

Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation

Steven K. Albanese, Brittany E. Hopkins, Andrea Olland, Alexis Fairman et autres

.

us, de (code pays fourni par la source)

Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors

Mayako Michino, Alexandre Beautrait, Nicholas A. Boyles, Aparna Nadupalli et autres

High Resolution Image Download MS PowerPoint Slide Lpd (lipoamide dehydrogenase) in Mycobacterium tuberculosis (Mtb) is required for virulence and is a genetically validated tuberculosis (TB) target. Numerous screens have been performed over the last decade, yet only two inhibitor series have been …

us (code pays fourni par la source)

Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis

Alexey Dementiev, Stephen Lillington, Shiyan Jin, Youngchang Kim et autres

Abstract Anaerobic fungi found in the guts of large herbivores are prolific biomass degraders whose genomes harbor a wealth of carbohydrate-active enzymes (CAZymes), of which only a handful are structurally or biochemically characterized. Here, we report the structure and kinetic rate parameters …

us (code pays fourni par la source)

Crystal Structure of the C-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli

Y. Kim, Alexey Dementiev, L. Welk, M. Endres et autres

Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis: expression, purification and crystallization. Corrigendum

Jasper Marc G. Bondoc, Hiten J. Gutka, Mashal M. Almutairi, Ryan Patwell et autres

The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F75, 646-651] is given.

us, sa, de (code pays fourni par la source)

Putative kojibiose phosphorylase from human microbiome

Alexey Dementiev, J. Osipiuk, M. Endres, Soichi Wakatsuki et autres

Automatic device for testing thermal resistance with thermoelectric effect

I M Vasiliev, А. И. Солдатов, Alexey Dementiev, A. A. Soldatov et autres

Abstract This paper presents the results of the developed device for testing thermal resistance of thermointerface. Experiments to determine thermal resistance in different cases of thermal interface application were carried out. Dependence of thermoEMF value is obtained, which occurs between semiconductor element …

ru (code pays fourni par la source)

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

Timothy Marlowe, Alexey Dementiev, Sheila Figel, Andrew Rivera et autres

BACKGROUND: Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors that target the kinase enzyme, recent attention has been focused …

us (code pays fourni par la source)

Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

Alexey Dementiev, A. Joachimiak, Ha Nguyen, A. Gorelik et autres

Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors. Despite the strong interest in obtaining structural …

us, ca (code pays fourni par la source)

Crystal structure of human acid ceramidase in covalent complex with carmofur

Alexey Dementiev, A. Joachimiak, N. Doan

Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors

Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li et autres

Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information, only the structure of the …

us (code pays fourni par la source)

Tendencies and prospects in the digital economy development in Russia

Yana Nikonova, Alexey Dementiev

The paper opens a series of publications within the framework of a project designed to investigate the impact of digitalization of the Russian economy on the qualitative change in its structure and long-term opportunities.

ru (code pays fourni par la source)