Leticia Pérez‐Rodríguez

Myeloid-avid mammalian target of rapamycin-inhibiting nanobiologic attenuates allograft fibrosis after lung transplantation

Katsutaka Mineura, Charles R. Liu, Junedh Amrute, Shinichi Kawana et autres

Chronic lung allograft dysfunction (CLAD) is characterized by fibrotic graft remodeling and limits long-term survival after pulmonary transplantation. Despite clinical evidence that myeloid cells drive conditions that increase the risk of CLAD development, contemporary immunosuppression primarily targets lymphocytes. We evaluated an mTOR-inhibiting …

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Infectious bursal disease virus (IBDV) as a novel oncolytic virotherapy in glioblastoma

Vicent Tur-Planells, Yonina Bykov, Gloria O Dawodu, Noemí Garcia‐Romero et autres

BACKGROUND: Glioblastoma (GBM) is the most aggressive form of cancer of the central nervous system. Despite advances in immunotherapies and standard-of-care treatments for GBMs, clinical outcomes remain limited-owing to the immunosuppressive tumor microenvironment and the intrinsic resistance of GBM to conventional approaches. …

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In vitro protocol demonstrating five functional steps of trained immunity in mice: Implications on biomarker discovery and translational research

Maria González-Pérez, Jana Baranda, Leticia Pérez‐Rodríguez, Patricia Conde et autres

We developed an in vitro methodology to study trained immunity using murine bone-marrow-derived macrophages stimulated with β-glucan and lipopolysaccharide (LPS). Longitudinal analysis of interleukin (IL)-6 and tumor necrosis factor (TNF) production demonstrates that trained macrophages secrete higher cytokine levels following primary stimulation …

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Late Breaking Abstract - Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation

Sarah-Eve S Lemay, Daniel Lozano-Ojalvo, Leticia Pérez‐Rodríguez, Mélanie Sauvaget et autres

Background: Idiopathic Pulmonary Fibrosis (IPF) is marked by progressive lung scarring with no existing cure, emphasizing the need for new therapeutic targets. Current evidence suggests that cyclic adenosine monophosphate (cAMP) mitigates lung fibroblast proliferation via the PKA pathway, but the impact of …

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Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation

Katherine Jankowski, Sarah E Lemay, Daniel Lozano-Ojalvo, Leticia Pérez‐Rodríguez et autres

Background Idiopathic pulmonary fibrosis (IPF) is marked by progressive lung scarring with no existing cure, emphasising the need for new therapeutic targets. Current evidence suggests that cyclic adenosine monophosphate (cAMP) mitigates lung fibroblast proliferation via the protein kinase A pathway, but the …

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Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity

Sara Benedé, Leticia Pérez‐Rodríguez, David Menchén‐Martínez, Elena Molina et autres

Background: It is well-documented that house dust mite (HDM) exposure can cause tissue damage and activate innate immune responses. However, its role in promoting gastrointestinal sensitization and allergenicity to food proteins has been relatively unexplored. Methods: This study investigates the immunostimulatory effects …

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In Vitro Method Demonstrating Trained Immunity as a Distinctive Functional Program: Implications for Biomarker Discovery, Adaptive Immune Responses, Sample Cryopreservation, and Mouse Genetics

Maria González-Pérez, Jana Baranda, Leticia Pérez‐Rodríguez, Patricia Conde et autres

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The phase I RELEASE clinical trial to evaluate the safety of NK cells in COVID-19

Clara Hernández-Blanco, Karima Al‐Akioui‐Sanz, Lara Herrera, Cristina Aguirre-Portolés et autres

/kg of NK cells. All participants' clinical status and inflammation markers were monitored. No serious adverse events were reported after infusion. Exploratory outcomes included the donor chimerism, NK-cell immunophenotype evolution, and immune lymphocyte reconstitution. This study provides preliminary evidence supporting the idea …

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Differential T follicular helper cell phenotypes distinguish IgE-mediated milk allergy from eosinophilic esophagitis in children

Daniel Lozano‐Ojalvo, Xin Chen, Wajiha Kazmi, David Menchén‐Martínez et autres

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Ingested dust mite favours sensitization to egg in mice independently of its proteinase activity

Sara Benedé, Leticia Pérez‐Rodríguez, David Menchén‐Martínez, Elena Molina et autres

Despite it is well documented that house dust mite (HDM) can cause tissue damage and activate innate immune cells, its potential to promote gastrointestinal sensitization and allergenicity to food proteins has been relatively unexplored. This study aimed to determine the immunostimulant properties …

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Airway Exposure to House Dust Mite Promotes the Development of Allergy to Egg White in Mice

Sara Benedé, Leticia Pérez‐Rodríguez, David Menchén‐Martínez, Elena Molina et autres

Letter to the Editor.

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A Phase I, Dose-Escalation Clinical Trial to Evaluate the Safety of Infusing Natural Killer Cells as Adoptive Therapy in COVID-19: Release

Clara Hernández-Blanco, Karima Al‐Akioui‐Sanz, Lara Herrera del Val, Cristina Aguirre-Portolés et autres

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