Daniel Lozano‐Ojalvo

Abstract 2904: Infectious bursal disease virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different cancer models

Vicent Tur Planells, Yonina Bykov, Gloria O Dawodu, Leticia Perez Rodriguez et autres

Abstract Within cancer immunotherapy, oncolytic viruses (OVs) are recognized as a promising and robust treatment approach. This study presents the potential of Infectious Bursal Disease Virus (IBDV), an avian-specific pathogen with no known human zoonosis, as a novel therapeutic agent. We assessed …

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A tumor-selective mRNA system enables precision cancer treatment

Magdalena M. Żak, Jimeen Yoo, Alberto Utrero‐Rico, Wencke Walter et autres

mRNA has revolutionized vaccine development, demonstrating high efficacy and safety in COVID-19 vaccines, and is now being explored for broader therapeutic applications. However, while vaccines rely on widespread antigen expression, many therapeutic strategies-particularly in oncology-require precise, cell-selective gene expression. Here, we present …

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PRDM15 regulates differentiation and proliferation of hematopoietic stem cells

Ernesto Guccione, Nesteene Joy Param, Alex Rialdi, Max Fortescue-Poole et autres

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897 Infectious bursal disease virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different murine cancer models

Vicent Tur-Planells, Gloria O Dawodu, Sara Izpura-Luis, Leticia Perez et autres

Background Within cancer immunotherapy, oncolytic viruses (OVs) are recognized as a promising and robust treatment approach. This study presents the potential of Infectious Bursal Disease Virus (IBDV), an avian-specific pathogen with no known human zoonosis, as a novel therapeutic agent.Methods We assessed …

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632 In situ APMV-4 vaccination achieves systemic tumor clearance and long-term antitumor immunity, priming response to sub-therapeutic dosing of aCTLA-4 in colorectal carcinoma

Yonina Bykov, Naseem Sadek, Gloria O Dawodu, Jeffrey Alan Tomalka et autres

Background In situ vaccination (ISV) with Newcastle Disease Virus (NDV) can promote antitumor immunity, yielding remarkable albeit limited success in clinical studies. Seeking a more efficacious virotherapy, we previously conducted several in vivo screens of avian avulaviruses related to NDV. We identified …

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Infectious bursal disease virus (IBDV) as a novel oncolytic virotherapy in glioblastoma

Vicent Tur-Planells, Yonina Bykov, Gloria O Dawodu, Noemí Garcia‐Romero et autres

BACKGROUND: Glioblastoma (GBM) is the most aggressive form of cancer of the central nervous system. Despite advances in immunotherapies and standard-of-care treatments for GBMs, clinical outcomes remain limited-owing to the immunosuppressive tumor microenvironment and the intrinsic resistance of GBM to conventional approaches. …

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Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion

Elena Garreta, Daniel Moya‐Rull, Alberto Centeno, Andrés Marco et autres

Organoids derived from human pluripotent stem (hPS) cells hold promise for therapeutic purposes. However, technological advances to overcome their massive production while ensuring differentiation fidelity are still lacking. Here we report a procedure sustaining the derivation of kidney organoids from hPS cells …

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In vitro protocol demonstrating five functional steps of trained immunity in mice: Implications on biomarker discovery and translational research

Maria González-Pérez, Jana Baranda, Leticia Pérez‐Rodríguez, Patricia Conde et autres

We developed an in vitro methodology to study trained immunity using murine bone-marrow-derived macrophages stimulated with β-glucan and lipopolysaccharide (LPS). Longitudinal analysis of interleukin (IL)-6 and tumor necrosis factor (TNF) production demonstrates that trained macrophages secrete higher cytokine levels following primary stimulation …

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The Use of Omics Sciences in Allergic Diseases From Bench to Bedside: An EAACI Position Paper

Chiara Tontini, Urszula Radzikowska, Carlos José Aranda, Marlena Tynecka et autres

Omics have revolutionized our understanding of allergic diseases, with increasingly more studies adopting techniques like genomics, proteomics, and metabolomics over the years. Integrating high‐dimensional omics data with clinical features can enable more precise disease classification and biomarker identification, leading to improved disease …

Ex Vivo IL ‐15‐Stimulated NK Cells as Adoptive Cell Therapy in Haploidentical Transplantation for Pediatric Leukemia

Carmen Mestre‐Durán, Odelaisy León‐Triana, Halin Bareke, Lidia Pertíñez et autres

A Phase I/II clinical trial was conducted in pediatric patients with high-risk malignancies to assess the safety and efficacy of NK cell infusion post-haplo-HSCT. Patients received either alloreactive NK cells from KIR/HLA-mismatched donors or IL-15-stimulated NK cells from KIR/HLA-matched donors, across three …

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The Use of Omics Sciences in Allergic Diseases From Bench to Bedside: An EAACI Position Paper

Chiara Tontini, Urszula Radzikowska, Carlos José Aranda, Marlena Tynecka et autres

Omics have revolutionized our understanding of allergic diseases, with increasingly more studies adopting techniques like genomics, proteomics, and metabolomics over the years. Integrating high-dimensional omics data with clinical features can enable more precise disease classification and biomarker identification, leading to improved disease …

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Abstract LB243: Secreted PTEN-long downregulates PI3K signaling and PD-L1 and promotes anti-tumor antigen-presenting cell functions to cause regressions of mouse tumors

Jia Xu, Tiphaine C. Martin, Daniel Lozano‐Ojalvo, Andrew D. Baik et autres

Abstract PTEN is well known as a tumor suppressor that inhibits the PI3K/AKT pathway, but the role of its secreted isoform PTEN-Long (PTEN-L) is not fully understood. We developed tools to study PTEN-L independent of PTEN using cancer cell lines engineered to …

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