Yingfu Jiao

Spinal cord stimulation attenuates itch-like behavior and dermatitis: Contribution of a spinal inhibitory neuronal ensemble and associated reductions in GRPR and sympathetic signaling

Zi Wang, Sihan Chen, Huimin Zhu, Wenjing Zhao et autres

BACKGROUND: Chronic inflammatory itch is sustained by reciprocal interactions among pruriceptive circuits, scratching-induced skin injury, immune-cell infiltration, and autonomic neuroimmune signaling. Spinal cord stimulation is known to reshape dorsal horn sensory processing, but whether it modulates neuroimmune inflammation during dermatitis-associated itch remains …

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Colitis-induced visceral pain recruits central neurotensin neurons that modulate colonic sensitivity

Yu-Ting Cheng, Natalie MacKinnon-Booth, Yingfu Jiao, Jordan R Robbins et autres

Abstract Inflammatory bowel disease produces debilitating visceral pain that remains a major clinical challenge. Notably, many patients experience persistent pain even after the inflammation resolves, indicating a sustained sensitization of central neural circuits that drives enduring pain. The brainstem parabrachial nucleus integrates …

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Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation

Xiaoqi Lin, Dan Yang, Shuyang Wang, Ling Zhu et autres

ABSTRACT Background Hepatic ischemia–reperfusion injury (HIRI) is a pathologic process commonly encountered during liver surgery, which seriously threatens patient prognosis. Currently, effective interventions or preventive measures are still lacking. Notably, patients with liver disease commonly experience brief acute stress prior to surgery; …

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S-adenosylmethionine and nicotinic acid suppress Hepatocellular carcinoma proliferation by targeting SLC25A4

Wenming Liu, Qiu-Qiu Zhang, Hong-Qian Ma, Cai–Yang Chen et autres

Hepatocellular carcinoma (HCC), an incurable malignancy with limited therapeutic options, exhibits mitochondrial dysfunction upon co-treatment with S-adenosylmethionine (SAM) and nicotinic acid (NA); however, the underlying mechanisms were undefined. Transcriptomic analysis identified dysregulation of the solute carrier (SLC) family gene SLC25A4. Subsequent experiments …

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Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum

Sa Wang, Xinxin Zhao, Dan Tang, Shian Li et autres

Precise anesthesia is essential to ensure perioperative safety in patients with hepatic encephalopathy (HE) due to severe liver injuries. Hyperammonemia has been implicated as a possible trigger for HE. However, anesthetic sensitivity in HE and the role of hyperammonemia, in the context …

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Correction: BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving Endoplasmic reticulum stress in mice with MASH

Yi Chen, Kangjie Xie, Cai–Yang Chen, Xihui Wang et autres

In this article (Chen et al. 2025), the legend of Figs.5E and 6E and F were omitted in Figs.

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BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH

Yi Chen, Kangjie Xie, Cai–Yang Chen, Xihui Wang et autres

BACKGROUND AND AIMS: Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases worldwide, and specific treatment modalities are lacking. Accumulating evidence suggests that hepatic inflammation plays a key role in the progression from hepatic steatosis to MASH. Macrophages, …

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Comprehensive bibliometric analysis of transcranial magnetic stimulation-based depression treatment from 2003 to 2022: Research hotspots and trends

Zhengyu Li, Yu-Wei Zhang, Haoran Yang, Hongjin Wu et autres

BACKGROUND: Depression has become a global public health problem. In recent years, transcranial magnetic stimulation (TMS) has gained considerable attention as a non-invasive treatment for depression. AIM: To investigate the research hotspots and trends in the field of TMS-based depression treatment from …

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Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells

Wenming Liu, Cai–Yang Chen, Hong-Qian Ma, Qiu-Qiu Zhang et autres

BACKGROUND: Hepatocellular carcinoma (HCC), the most common form of liver cancer, presents a challenging malignancy with scarce treatment options. Liver progenitor cells (LPCs) play a pivotal role in both liver regeneration and the progression of liver cancer, yet the specific functions of …

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P188 THE SPINAL CORD STIMULATION SUPPRESSES BONE CANCER PROGRESSION AND -RELATED PAIN THROUGH MODULATION OF SPECIFIC SPINAL GABAERGIC NEURON DRIVED NEURAL CIRCUIT

Yingfu Jiao, Bingxue Peng, Yinghui Fan, Weifeng Yu

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Human liver progenitor-like cells-derived extracellular vesicles promote liver regeneration during acute liver failure

Yi Chen, Yu‐Ling Wu, Hanyong Sun, Hongdan Zhang et autres

Hepatocyte-derived liver progenitor-like cells (HepLPCs) exhibit a remarkable capacity to support liver function by detoxifying ammonia, promoting native liver regeneration, and suppressing inflammation, which leads to improvements in the recovery and survival of animals with acute liver failure (ALF). However, the mechanism …

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A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice

Yanyu Zhou, Xiaoqi Lin, Yingfu Jiao, Dan Yang et autres

As the ability of liver regeneration is pivotal for liver disease patients, it will be of high significance and importance to identify the missing piece of the jigsaw influencing the liver regeneration. Here, we report that chronic stress impairs the liver regeneration …

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