Huimin Zhu

Spinal cord stimulation attenuates itch-like behavior and dermatitis: Contribution of a spinal inhibitory neuronal ensemble and associated reductions in GRPR and sympathetic signaling

Zi Wang, Sihan Chen, Huimin Zhu, Wenjing Zhao et autres

BACKGROUND: Chronic inflammatory itch is sustained by reciprocal interactions among pruriceptive circuits, scratching-induced skin injury, immune-cell infiltration, and autonomic neuroimmune signaling. Spinal cord stimulation is known to reshape dorsal horn sensory processing, but whether it modulates neuroimmune inflammation during dermatitis-associated itch remains …

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Ferroptosis and Its Crosstalk with Other Cell Death Modes in Ischemic Stroke

Huimin Zhu, Li Hui Zhou, W W Yu, Qin Yang

Ischemic stroke is the most common cerebrovascular disease. The core pathological mechanism underlying its neurological deficits is the massive neuronal death triggered by cerebral ischemia, hypoxia, and reperfusion injury following a sudden interruption of cerebral blood flow. Ferroptosis is a form of …

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Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu et autres

BACKGROUND: Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. Thus, inhibiting microglial over-activation is crucial for reducing ischemic injury. Sirtuin 1 (Sirt1) has been shown to play a …

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Resveratrol Inhibits Oxidative Stress and Regulates M1/M2-Type Polarization of Microglia via Mediation of the Nrf2/Shh Signaling Cascade after OGD/R Injury In Vitro

Jie Liu, Hongyan Liao, Yue Chen, Huimin Zhu et autres

AIMS: Microglia are closely related to the occurrence and development of oxidative stress. Cerebral ischemia leads to abnormal activation of microglia. Resveratrol can regulate M1/M2-type microglia polarization, but the underlying mechanism is not well understood, although the Nrf2 and Shh signaling pathways …

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Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu et autres

Abstract Background: Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. Thus, inhibiting microglial over-activation is crucial for reducing ischemic injury. Sirtuin 1 (Sirt1) has been shown to play …

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Effects of Resveratrol on Astrocytic Activation after OGD/R and MCAO/R Injury via Mediation of the Sirt1-Shh Signaling

Jing Liu, Hongyan Liao, Pingping Yu, Jie Liu et autres

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Recent advance in protective mechanism of regulatory T cells in secondary injury of intracerebral hemorrhage

Huimin Zhu, Jixu Yu, Nian Wang, Lijuan Wang et autres

Intracerebral hemorrhage (ICH) is a serious acute cerebrovascular disease, and secondary injury is one of the important mechanisms of injury after ICH. Studies have confirmed that regulatory T cells (Tregs) play important protective roles after ICH by modulating microglial phenotype and inhibiting …

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Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

Huimin Zhu, Zhiqiang Wang, Jixu Yu, Xiuli Yang et autres

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