Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation
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Le résumé fourni par la source
ABSTRACT Background Hepatic ischemia–reperfusion injury (HIRI) is a pathologic process commonly encountered during liver surgery, which seriously threatens patient prognosis. Currently, effective interventions or preventive measures are still lacking. Notably, patients with liver disease commonly experience brief acute stress prior to surgery; however, the impact of acute stress on HIRI remains unclear. Methods A 30‐min restraint stress was used to simulate acute restraint stress (ARS). Hematoxylin–eosin staining and ELISA were employed to assess HIRI. Immunofluorescence staining and electrophysiology were applied to evaluate neuronal activation. Chemogenetic manipulation was utilized to verify the role of corticotropin‐releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) in ARS‐mediated attenuation of HIRI. Results The results showed that ARS significantly ameliorated liver injury, reduced the liver enzyme levels (ALT and AST), and down‐regulated the inflammatory factors expression in HIRI mice. Furthermore, we found that ARS alleviated HIRI by activating the hypothalamic–pituitary–adrenal (HPA) axis to release corticosterone, rather than through the sympathetic nervous system. PVN CRH represented a critical subpopulation responding to ARS. Chemogenetic activation of PVN CRH neurons mimicked the protective effect of ARS against HIRI, whereas chemogenetic inhibition of these neurons abolished this protection. Conclusion Our findings demonstrate that PVN CRH neurons mediate the protective effect of ARS against HIRI by activating the HPA axis to release corticosterone. This work may provide key insights for developing perioperative strategies to prevent HIRI.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation
- Date Crossref
- 01/01/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shanghai Jiao Tong University Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
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Renji Hospital pays non établi dans la noticeÉtablissement de santé
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Wenzhou Medical University Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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Zhejiang Lab pays non établi dans la noticeStructure de recherche
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Anhui Medical University pays non établi dans la noticeUniversité ou école supérieure
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Chaohu Hospital of Anhui Medical University pays non établi dans la noticeÉtablissement de santé
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Fourth Affiliated Hospital of Anhui Medical University pays non établi dans la noticeÉtablissement de santé
Department of Anesthesiology — Shanghai Jiao Tong University, Renji Hospital et Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine — Wenzhou Medical University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.