Benjamin Johnston

Maternal and pregnancy outcomes in women offered daily oral preexposure prophylaxis during pregnancy and postpartum

Benjamin H. Chi, Deborah Kacanek, Emily Brown, K. Rivet Amico et autres

OBJECTIVE: To compare maternal safety and pregnancy outcomes among women who did and did not use daily oral emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) for preexposure prophylaxis (PrEP) during pregnancy and postpartum. DESIGN: Parallel cohort design, with follow-up from pregnancy to 6 months postpartum. …

us, Zimbabwe, Afrique du Sud, Ouganda, Malawi (code pays fourni par la source)

Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV

Risa M. Hoffman, Sean Brummel, Mauricio Pinilla, Grace P. Malonga et autres

INTRODUCTION: We performed an analysis of incident hypertension in a randomized trial comparing dolutegravir (DTG) + emtricitabine (F)/tenofovir alafenamide (TAF) versus DTG + F/tenofovir disoproxil fumarate (TDF) versus efavirenz (EFV)/F/TDF in pregnant and postpartum women with HIV. METHODS: Women were randomized at …

us, Malawi, Zimbabwe, br, in, Botswana, th, Afrique du Sud (code pays fourni par la source)

Brief Report: Breast Milk Transfer and Infant Exposures to Dolutegravir, Tenofovir, and Tenofovir Alafenamide: Results From IMPAACT 2010/VESTED

Tk Nguyen, Jung‐woo Chae, Lauren Ziemba, Anne Coletti et autres

BACKGROUND: Limited information is available on breast milk transfer and subsequent infant systemic exposure to dolutegravir (DTG), tenofovir alafenamide (TAF), and tenofovir (TFV). We evaluated concentrations of DTG, TAF, and TFV in maternal and infant plasma and breast milk from participants of …

us, Zambie, Zimbabwe, Ouganda, Botswana, Afrique du Sud, Tanzanie, in (code pays fourni par la source)

Safety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07–523LS in Newborn Infants Exposed to HIV-1

Coleen K. Cunningham, Elizabeth J. McFarland, Petronella Muresan, Edmund V. Capparelli et autres

BACKGROUND: Vertical HIV-1 transmission despite antiretroviral therapy may be mitigated by the use of long-acting, broadly neutralizing, monoclonal antibodies (bNAb) such as VRC07-523LS. The present study was designed to determine the safety and pharmacokinetics of VRC07-523LS. METHODS: VRC07-523LS, 80 mg/dose, was administered …

us, Afrique du Sud, Zimbabwe (code pays fourni par la source)

Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants

Denise L. Jacobson, Krista S. Crider, Patricia DeMarrais, Sean S. Brummel et autres

BACKGROUND: In the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2010/VESTED study, pregnant women were randomized to initiate dolutegravir (DTG) + emtricitabine (FTC)/tenofovir alafenamide (TAF), DTG + FTC/tenofovir disoproxil fumarate (TDF), or efavirenz (EFV)/FTC/TDF. METHODS: We assessed red blood cell (RBC) …

us, Botswana, Zimbabwe, Ouganda, Afrique du Sud, br, Tanzanie, ca, Malawi (code pays fourni par la source)

Pharmacokinetics and Safety of Remdesivir in Pregnant and Nonpregnant Women With COVID-19: Results From IMPAACT 2032

Kristina M. Brooks, Kristin Baltrusaitis, Diana F. Clarke, Sharon Nachman et autres

BACKGROUND: Pregnant people with coronavirus disease 2019 (COVID-19) experience higher risk for severe disease and adverse pregnancy outcomes, but no pharmacokinetic (PK) data exist to support dosing of COVID-19 therapeutics during pregnancy. We report PK and safety data for intravenous remdesivir in …

us, hu, pk (code pays fourni par la source)

Efficacy and safety of three antiretroviral therapy regimens started in pregnancy up to 50 weeks post partum: a multicentre, open-label, randomised, controlled, phase 3 trial

Lameck Chinula, Lauren Ziemba, Sean S. Brummel, Katie McCarthy et autres

us, Malawi, Botswana, Zimbabwe, Ouganda, Afrique du Sud, Tanzanie, gb (code pays fourni par la source)

Evaluation of Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV/ΔNS2/Δ1313/I1314L and RSV/276 in RSV-Seronegative Children

Coleen K. Cunningham, Ruth A. Karron, Petronella Muresan, Matthew S. Kelly et autres

BACKGROUND: This United States-based study compared 2 candidate vaccines: RSV/ΔNS2/Δ1313/I1314L, attenuated by NS2 gene-deletion and temperature-sensitivity mutation in the polymerase gene; and RSV/276, attenuated by M2-2 deletion. METHODS: RSV-seronegative children aged 6-24 months received RSV/ΔNS2/Δ1313/I1314L (106 plaque-forming units [PFU]), RSV/276 (105 PFU), …

us (code pays fourni par la source)

Tenofovir Diphosphate Concentrations in Dried Blood Spots From Pregnant and Postpartum Adolescent and Young Women Receiving Daily Observed Pre-exposure Prophylaxis in Sub-Saharan Africa

Lynda Stranix‐Chibanda, Peter L. Anderson, Deborah Kacanek, Sybil Hosek et autres

BACKGROUND: Intracellular tenofovir diphosphate (TFV-DP) concentration in dried blood spots (DBSs) is used to monitor cumulative pre-exposure prophylaxis (PrEP) adherence. We evaluated TFV-DP in DBSs following daily oral PrEP (emtricitabine 200 mg/tenofovir diphosphate 300 mg) among pregnant and postpartum adolescent girls and …

Zimbabwe, us, Malawi, Ouganda, Afrique du Sud (code pays fourni par la source)

Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants

Coleen K. Cunningham, Elizabeth J. McFarland, R. L. Morrison, Edmund V. Capparelli et autres

BACKGROUND: Although mother-to-child human immunodeficiency virus (HIV) transmission has dramatically decreased with maternal antiretroviral therapy, breast milk transmission accounts for most of the 180 000 new infant HIV infections annually. Broadly neutralizing antibodies (bNAb) may further reduce transmission. METHODS: A Phase 1 …

us, Zimbabwe, Afrique du Sud (code pays fourni par la source)

Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults

Nathan Hanan, Mary E. Paul, Yanling Huo, Suad Kapetanovic et autres

Objective. Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of sertraline pharmacokinetics in HIV-infected youth. Methods. IMPAACT P1080 was a multicenter …

us (code pays fourni par la source)

Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy.

Ian S. Cadden, A Atkinson, Benjamin Johnston, K.M. Pogue et autres

Abstract Aims: Phaeochromocytomas are rare but potentially life-threatening neuroendocrine tumours of the adrenal medulla or sympathetic nervous system ganglia. There are no histological features which reliably differentiate benign from malignant phaeochromocytomas. The current study evaluated cyclooxygenase-2 (Cox-2) and Bcl-2 as tissue-based biomarkers …