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2026
article
Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV
Risa M. Hoffman, Sean Brummel, Mauricio Pinilla, Grace Malonga, L. Chinula, Lynda Stranix‐Chibanda, Elizabeth S. Machado, Shilpa Naik, Mobeen H. Rathore, José Henrique Pilotto, Gaerolwe Masheto, Jeffrey S A Stringer, Roger Shapiro, CD Mitchell, Katie McCarthy, Esaú Custódio João, Tim R. Cressey, Sherika Hanley, Patrick Jean‐Philippe, Chelsea Stotz, Paul Sax, Judith S Currier, Shahin Lockman, IMPAACT 2010/VESTED Study Team, Sharon Nachman, David P. Harrington, Catherine Hill, Steven Joffe, Alwyn Mwinga, Andrew Nunn, Merlin L Robb, Haroon Saloojee, Jonathan Kimmelman, Graeme Meintjes, Barbara E. Murray, Stuart C. Ray, Anastasios A. Tsiatis, Paul A Volberding, David Glidden, Valéria C. Rolla, Nahida Chakhtoura, Jeanna Piper, Karin L. Klingman, Debika Bhattacharya, Lynne Mofenson, Lauren Ziemba, Benjamin Johnston, Scott McCallister, Jean van Wyk, Mark Mirochnick, Brookie Best, Kevin Robertson, Cheryl Blanchette, Nagawa Jaliaah, Andi Fox, Frances Whalen, Kevin Knowles, William Murtaugh, Yao Cheng, Anne Coletti, Lisa M. Frenkel, K Rivet Amico, Lewis B. Holmes, Jeremiah D. Momper, Lesedi Tirelo, Boitshepo J Seme, Georginah O Modise, Mpho S Raesi, Marian Budu, Moakanyi Ramogodiri, Thalita Fernandes de Abreu, Lorena Macedo Pestanha, Leon Claude Sidi, Trevon Fuller, Maria Leticia Santos Cruz, Jorge Andrés Pinto Pinto, Flãvia Ferreira, Mario Ernesto Donoso Correa, Juliana Ribeiro Romeiro, Luis Eduardo Barros Costa Fernandes, Luiz Felipe Moreira, Ivete Martins Gomes, Vidya Mave, Aarti Kinikar, Lee Fairlie, Elizea Horne, Faeezah Patel, Hamisha Soma-Kasiram, Haseena Cassim, Sisinyana Ruth Mathiba, Mandisa Nyati, Jeanne de Jager, Magdel Rossouw, Lindie Rossouw, Alicia Catherine Desmond, Rosemary Gazu, Vani Govender, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Peerawong Werarak, Supattra Rungmaitree, Jullapong Achalapong, Lukkana Sitiritkawin, Pra-ornsuda Sukrakanchana, Fuanglada Tongprasert, Chintana Khamrong, Sopida Kiattivej, Deo Wabwire, Enid Kabugo, Joel Maena, Beatrice Nagaddya, Rogers Sekabira, Justus Ashaba, Charles D Mitchell, Adriana Drada, Grace A Alvarez, Gwendolyn B Scott, Saniyyah Mahmoudi, Adnan Shabbir, Nizar Maraqa, Patricia Mandima, Mercy Mutambanengwe, Suzen Maonera, Gift Chareka, Vongai Chanaiwa, Taguma Allen Matubu, Kevin Tamirepi, Sukunena Maturure, Tsungai Mhembere, Tichaona Vhembo, Tinashe Chidemo, Sharon Nachman, Paul A Volberding, Valeria Cavalcanti Rolla, Nahida Chakhtoura, Karin Klingman, Lynne Mofenson, Scott McCallister, Jean van Wyk, Cheryl Blanchette, Yao Cheng, Anne Coletti, Lisa Frenkel, K Rivet Amico, Gaerolwe Masheto, Jeremiah Momper, Lynda Stranix-Chibanda, Mpho S Raesi, Trevon Fuller, Maria Leticia Santos Cruz, Jorge Pinto, Flãvia Ferreira, Mario Correa, Juliana Romeiro, Shilpa Naik, Vidya Mave, Aarti Kinikar, Haseena Cassim, Mandisa Nyati, Jeanne de Jager, Magdel Rossouw, Alicia Catherine Desmond, Deo Wabwire, Joel Maena, Justus Ashaba, Gwendolyn B Scott, Mobeen Rathore, Nizar Maraqa, Gift Chareka, Tsungai Mhembere
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Résumé fourni par la source
INTRODUCTION: We performed an analysis of incident hypertension in a randomized trial comparing dolutegravir (DTG) + emtricitabine (F)/tenofovir alafenamide (TAF) versus DTG + F/tenofovir disoproxil fumarate (TDF) versus efavirenz (EFV)/F/TDF in pregnant and postpartum women with HIV. METHODS: Women were randomized at 14-28 weeks gestational age (GA) to start DTG + F/TAF, DTG + F/TDF, or EFV/F/TDF and followed through 50 weeks postpartum. The composite incident hypertension outcome was defined as initiation of antihypertensive medication or ≥2 elevated blood pressures categorized as elevated (130-139 and/or 80-89 mmHg), mild (140-159 and/or 90-99 mmHg), moderate (≥160-179 and/or ≥100-109 mmHg), and severe (≥180 and/or ≥110 mmHg). Incident gestational hypertension was defined by initiation of antihypertensive medication or ≥2 blood pressures ≥ 140 and/or ≥90 mmHg at ≥20 weeks GA with resolution by 12 weeks postpartum. Cox proportional hazard models were used for by-arm comparisons of the composite outcome and to look for the effect of weight change within arm. RESULTS: Of 626 women without baseline hypertension (median age 26.6 years), the composite incident outcome occurred in 49% (n = 308), predominantly due to the incident elevated category of elevated blood pressure, with no significant differences by arm, although hypertension was numerically more likely in the DTG arms. Each additional 5 kg of weight was associated with an 8%-17% higher hazard of the composite hypertension outcome. Twenty-seven participants (4.3%) had gestational hypertension with no apparent differences between arms. CONCLUSIONS: Our data contribute information regarding the safety of DTG-based ART and TAF in pregnant and postpartum women and highlight the importance of monitoring weight and performing hypertension screening as part of maternal health care for young women with HIV.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV
- Date Crossref
- 13/04/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
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Sujets associés
HIV-related health complications and treatmentsHIV/AIDS drug development and treatmentPregnancy and preeclampsia studies