Accès ouvert
2024
article
OpenAlex
Tsung-Ta Chiang, Ming‐Hsien Chiang, Hung-Jen Tang, Zhi‐Yuan Shi et autres
BACKGROUND: Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the clinical efficacy of CPZ/SUL for the treatment of K. pneumoniae bacteremia has not been …
tw
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Accès ouvert
2024
preprint
OpenAlex
Tsung-Ta Chiang, Ming‐Hsien Chiang, Hung-Jen Tang, Zhi‐Yuan Shi et autres
Abstract Background Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the clinical efficacy of CPZ/SUL for the treatment of K. pneumoniae bacteremia has not …
tw, cn, us
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2024
article
OpenAlex
R. C. Chen, Po‐Liang Lu, Tsung-Ying Yang, Shang‐Yi Lin et autres
OBJECTIVE: We aimed to assess the efficacy of cefoperazone/sulbactam (CPZ/SUL) in extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections and identify factors influencing outcomes. METHODS: This retrospective multicentre study was conducted in Taiwan (January 2015 to December 2020) and examined the efficacy of CPZ/SUL treatment …
tw, jp
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Accès ouvert
2023
article
OpenAlex
Chia-Hung Tsai, Yu-Chin Chen, Po‐Yu Chen, Chih‐Cheng Lai et autres
Purpose: To investigate the antibiotic susceptibility of Escherichia coli isolates in patients diagnosed with intra-abdominal infections (IAIs) in the Asia-Pacific region. Patients and Methods: This study was conducted at 50 medical hospitals across 9 countries/regions as part of the Study for Monitoring …
tw
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Accès ouvert
2022
article
OpenAlex
Hung-Jen Tang, Chi‐Chung Chen, Ying-Chen Lu, Hui-Ling Huang et autres
Objectives This study investigated the inhibitory effect of Lactobacillus spp. with prebiotics against Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing Klebsiella pneumoniae using both in vitro experiments and animal models. Methods Thirty-three Lactobacillus spp. strains were confirmed by 16S rDNA sequencing, and four different PFGE …
tw
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Accès ouvert
2022
article
OpenAlex
Shang‐Yi Lin, Po‐Liang Lu, Ting‐Shu Wu, Shian‐Sen Shie et autres
INTRODUCTION: The clinical efficiency of cefoperazone/sulbactam (CPZ/SUL) against Escherichia coli bacteremia was unknown. This study aimed to explore the relationship between CPZ/SUL MIC values and clinical outcomes in Escherichia coli bacteremia. METHODS: A multicenter, retrospective, observational cohort study was conducted in Taiwan …
tw
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Accès ouvert
2021
article
OpenAlex
Feng‐Yee Chang, Yin-Ching Chuang, Balaji Veeraraghavan, Anucha Apisarnthanarak et autres
Abstract Background Most studies on hospital antimicrobial stewardship (AMS) status and practices are conducted in the west, and there is a lack of such data from Asian countries. The objective of this survey was to determine existing AMS practices and gaps, and …
tw, in, th, ph, sg, my, id, pk, jp, vn
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Accès ouvert
2021
article
OpenAlex
Yu-Chin Chen, Wei-Yu Chen, Wei-Yun Hsu, Hung-Jen Tang et autres
PURPOSE: In this study, we aimed to assess the geographic distribution and molecular characteristics of β-lactamases among Enterobacterales isolates causing intra-abdominal infections (IAIs) from 2015 to 2018 in the Asia-Pacific region. METHOD: Isolates were investigated for extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, and …
tw
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2021
article
OpenAlex
Hung-Jen Tang, Yi-Tsung Lin, Chi-Chung Chen, Chih‐Wei Chen et autres
OBJECTIVES: To investigate the in vitro activity of antibiotics against clinical Elizabethkingia anophelis isolates and to find a suitable antibiotic combination with synergistic effects to combat antibiotic-resistant E. anophelis and its associated biofilm. METHODS: E. anophelis isolates were identified by 16S rRNA …
tw
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Accès ouvert
2021
dataset
OpenAlex
Yi‐Wei Chen, Wen-Hsuan Yeh, Hung-Jen Tang, Jenn‐Wei Chen et autres
Aeromonas dhakensis is an emerging human pathogen which causes fast and severe infections worldwide. Under the gradual pressure of lacking useful antibiotics, finding a new strategy against A. dhakensis infection is urgent. To understand its pathogenesis, we created an A. dhakensis AAK1 …
tw
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Accès ouvert
2021
dataset
OpenAlex
Yi‐Wei Chen, Wen-Hsuan Yeh, Hung-Jen Tang, Jenn‐Wei Chen et autres
Aeromonas dhakensis is an emerging human pathogen which causes fast and severe infections worldwide. Under the gradual pressure of lacking useful antibiotics, finding a new strategy against A. dhakensis infection is urgent. To understand its pathogenesis, we created an A. dhakensis AAK1 …
tw
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Accès ouvert
2020
article
OpenAlex
Chien Chuang, Chin-Fang Su, Jung‐Chung Lin, Po‐Liang Lu et autres
Few clinical studies have previously discussed patients with carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria. This study aimed to assess the effect of antimicrobial therapy on the mortality of patients with CRKP bacteriuria. Hospitalized adults with CRKP bacteriuria were enrolled retrospectively from 16 hospitals …
tw
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