Tsung-Ying Yang

Molecular epidemiology and emerging tet (X)-associated resistance of Elizabethkingia spp. in Taiwan, 2016–2022

Yu-Tsung Huang, Cheng‐Yen Kao, Han‐Yueh Kuo, Li-Ting Kao et autres

ABSTRACT Elizabethkingia species are opportunistic gram-negative pathogens associated with nosocomial infections and limited therapeutic options. Longitudinal data characterizing antimicrobial resistance and molecular determinants in Taiwan remain scarce. A total of 191 non-duplicate Elizabethkingia clinical isolates were collected at the National Taiwan University …

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Outcomes associated with carbapenem-sparing versus carbapenem-containing therapy for third-generation cephalosporin non-susceptible Serratia marcescens bacteremia: a retrospective cohort analysis

Shin‐Huei Kuo, Shang‐Yi Lin, Tsung-Ying Yang, Tun‐Chieh Chen et autres

BACKGROUND: Recent IDSA guidance supports carbapenem-sparing options for AmpC-producing Enterobacterales, but clinical evidence for third-generation cephalosporin non-susceptible (3 GC-NS) Serratia marcescens bloodstream infection (BSI) remains limited. We aimed to identify risk factors for 3 GC-NS acquisition and evaluate the safety of carbapenem-sparing …

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A Pilot Study to Develop an Ultrasensitive Thio-NAD Cycling ELISA for Neisseria gonorrhoeae Detection

Po-Kai Chen, Tsung-Ying Yang, Jiawen Li, Hung-Jen Tang et autres

Neisseria gonorrhoeae and its increasing antimicrobial resistance have raised global health concerns, creating an urgent need for more advanced diagnostics to contain the spread. We conducted a preclinical trial using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) with Thio-nicotinamide-adenine dinucleotide (NAD) cycling for …

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The role of P30 adhesin detected by ultrasensitive ELISA in the clinical diagnosis and management of Mycoplasma pneumoniae

Po-Kai Chen, Kan-Hsuan Lin, Guan‐Ming Ke, Shun‐Cheng Yang et autres

BACKGROUND: Mycoplasma pneumoniae (MP) is a common cause of pediatric respiratory infections, but its diagnosis remains challenging due to nonspecific clinical features and the limitations of conventional laboratory tests. METHODS: We evaluated the diagnostic and clinical utility of P30 detection using the …

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Lauryl gallate induces apoptosis via p38-MAPK phosphorylation and autophagy in chemoresistant human lung cancer cells

Yen-Hsiang Huang, Shur‐Hueih Cherng, Ling‐Yen Chiu, Kuo-Hsuan Hsu et autres

Human lung cancer has taken many lives and chemoresistance generally occurs in patients and reduces patients' survival. Docetaxel (DOC) and vincristine (VCR) have been widely used in cancer chemotherapy but their efficacy is restricted by P-glycoprotein (P-gp) overexpression. Lauryl gallate (LG) is …

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Enzyme-linked immunosorbent STI assays: development, current status and future perspective

Po‐Liang Lu, Etsuro Ito, Tsung-Ying Yang

Sexually transmitted infections (STIs) continue to pose major public health challenges globally, with millions of new cases reported annually. The asymptomatic characteristic of many STIs makes accurate and cost-effective diagnostic methods essential for screening and diagnosis. This paper evaluates the utility of …

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In Silico Design of Antimicrobial Peptides against Carbapenem-Resistant Acinetobacter baumannii Infections with Enhanced Activity by Nanoformulation

Richardson Lawrance, Tsung-Ying Yang, Yu‐Wei Chen, Shang‐Yi Lin et autres

High Resolution Image Download MS PowerPoint Slide Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a critical public health menace. Its resistance to last-resort antibiotics highlights the urgent need for innovative treatment approaches. Antimicrobial peptides (AMPs) are promising candidates to address this challenge. …

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Mechanistic insights into CLNS1A-mediated chemoresistance and tumor progression in non-small cell lung cancer

Tong‐You Wade Wei, Jiun‐Yi Hsia, Tsung-Ying Yang, Guozhi Wang et autres

CLNS1A is a chloride channel protein and an essential component of the methylosome complex, which additionally comprises PRMT5 and MEP50. In this study, we investigated its contribution to lung cancer and its potential as a therapeutic target. Analysis of transcriptomic datasets and …

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Synergistic effect between taurine-induced silver ion and itraconazole against azole-resistant Candida species and Candida auris

Chi‐Jen Shih, Shang‐Yi Lin, Liang‐Chun Wang, Tsung-Ying Yang et autres

BACKGROUND: Azole antifungals are the first-line choice for treating candidiasis within a limited antifungal option. However, azole-resistant Candida species have increased rapidly, causing severe clinical threats, especially multidrug-resistant (MDR) isolates. The emergence of Candida auris has also caused global concerns recently. METHODS: …

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Assessment of silver-copper co-loaded mesoporous bioactive glass as an advanced pulp-capping material

Jung‐Chang Kung, Hui-Ci Yang, Tsung-Ying Yang, Chi‐Jen Shih

OBJECTIVES: To evaluate the multifunctionality of silver-copper co-loaded mesoporous bioactive glass (MBG), with the goal of developing an advanced pulp-capping material. METHODS: The synthesis of materials was conducted using the sol-gel method, following the approach described in previous studies but with some …

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In Vivo Effect of Halicin on Methicillin-Resistant Staphylococcus aureus-Infected Caenorhabditis elegans and Its Clinical Potential

Li-Ting Kao, Tsung-Ying Yang, Wei‐Chun Hung, Wei-Te Yang et autres

Recently, the high proportion of methicillin-resistant Staphylococcus aureus infections worldwide has highlighted the urgent need for novel antibiotics to combat this crisis. The recent progress in computational techniques for use in health and medicine, especially artificial intelligence (AI), has created new and …

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Antimicrobial efficacy and amino acid substitutions associated with susceptibility to the tellurium compound AS101 against Haemophilus influenzae and Haemophilus parainfluenzae

Cheng-Hsun Ho, Tsung-Ying Yang, Sung‐Pin Tseng, Pei-Yi Su

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