Yifei Shen

Patient-Similarity Cohort Reasoning in Clinical Text-to-SQL

Yifei Shen, Yilun Zhao, Justice Ou, Tinglin Huang et autres

Real-world clinical text-to-SQL requires reasoning over heterogeneous EHR tables, temporal windows, and patient-similarity cohorts to produce executable queries. We introduce CLINSQL, a benchmark of 633 expert-annotated tasks on MIMIC-IV v3.1 that demands multi-table joins, clinically meaningful filters, and executable SQL. Solving CLINSQL …

Patient-Similarity Cohort Reasoning in Clinical Text-to-SQL

Yifei Shen, Yilun Zhao, Justice Ou, Tinglin Huang et autres

Real-world clinical text-to-SQL requires reasoning over heterogeneous EHR tables, temporal windows, and patient-similarity cohorts to produce executable queries. We introduce CLINSQL, a benchmark of 633 expert-annotated tasks on MIMIC-IV v3.1 that demands multi-table joins, clinically meaningful filters, and executable SQL. Solving CLINSQL …

Interpretable multimodal deep learning improves postoperative risk stratification in intrahepatic cholangiocarcinoma in multicentre cohorts

Mingyu Wan, Yongfeng Ding, Yanli Wang, Yunlu Jia et autres

Surgical resection is the primary curative treatment for intrahepatic cholangiocarcinoma (ICC), yet high postoperative recurrence rates pose a significant challenge. We developed an interpretable, transformer-based deep-learning pipeline that integrates multimodal data-including clinical variables, radiomic features, and whole-slide pathology images-by fusing a pre-trained …

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Metagenomic fingerprints in bronchoalveolar lavage differentiate pulmonary diseases

Dongsheng Han, Chang Liu, Bin Yang, Fei Yu et autres

Recent advances in unbiased metagenomic next-generation sequencing (mNGS) enable simultaneous examination of microbial and host genetic material. We developed a multimodal machine learning-based diagnostic approach to differentiate lung cancer and pulmonary infections by analyzing 402 bronchoalveolar lavage fluid (BALF) mNGS datasets, including …

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International multicenter development of ensemble machine learning driven host response based diagnosis for tuberculosis

Shufa Zheng, Wenxin Qu, Dan Zhang, Jieting Zhou et autres

= 1,786) comprising both children and adults from seven countries. Thus, our data demonstrates that TB-Scope provides a powerful and reliable tool for accurately diagnosing ATB across diverse data platforms.

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An emerging role of mitochondrial quality control in bone metabolism: from molecular mechanisms to targeted therapeutic interventions

Xiting Zhu, Yifei Shen, Huiling Ling, Ngaifung Ruan et autres

The mitochondrial quality control system is the principal regulatory framework governing mitochondrial quantity, morphology, distribution, and functional integrity. This surveillance and regulatory machinery is essential for preserving cellular homeostasis and determining cellular differentiation. Mitochondria play a central role in maintaining the dynamic …

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Multimodal Metagenomic Profiling of Bronchoalveolar Lavage Fluid for Diagnostic Classification of Pulmonary Diseases

Dongsheng Han, Fei Yu, Bin Lou, Bin Yang et autres

cn (code pays fourni par la source)

Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study

Yifei Shen, Dongsheng Han, Wenxin Qu, Fei Yu et autres

BACKGROUND: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting early and accurate diagnosis of infection. METHODS: To …

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Effects of high vp28 expression in Synechocystis sp. PCC6803 constructed by homologous recombination on immunity and antioxidant capacity of white spot syndrome virus infected Litopenaeus vannamei

Ning Ding, Jia Yang, Hang Zhang, Xiaojun Qi et autres

cn (code pays fourni par la source)

A case report on Madelung’s disease and comprehensive review of the literature

Cheng Jiao, W.J. Liu, Yiming Qiao, Shuai Qi et autres

BACKGROUND: Madelung's disease (MD), alternatively referred to as benign symmetric lipomatosis, multiple symmetric lipomatosis, or Launois-Bensaude syndrome, is an uncommon benign disorder marked by symmetric proliferation of adipose tissue in the head, neck, and torso regions. CASE DESCRIPTION: In this case, the …

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Compression-Realized Deep Structural Network for Video Quality Enhancement

Hanchi Sun, Xiaohong Liu, Xinyang Jiang, Yifei Shen et autres

This paper focuses on the task of quality enhancement for compressed videos. Although deep network-based video restorers achieve impressive progress, most of the existing methods lack a structured design to optimally leverage the priors within compression codecs. Since the quality degradation of …

Metagenomic Analysis of Bronchoalveolar Lavage Fluid Enables Differential Diagnosis Between Lung Cancer and Pulmonary Infections

Yu Chen, Dongsheng Han, Fei Yu, Bin Yang et autres

cn, us (code pays fourni par la source)