Jieting Zhou

Clinical and Genomic Insights into the Allodiploid Hybrid Pathogen Aspergillus latus: A Retrospective Case Series

Yuqing Chen, Jieting Zhou, Lingjun Yuan, Mengxiao Xie et autres

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Bronchoalveolar lavage fluid metagenomic datasets: a multidimensional clinical biomolecular resource

Hui Tang, Huifang Liu, Lingjun Yuan, Mengxiao Xie et autres

Metagenomic Next-Generation Sequencing (mNGS) enables simultaneous sequencing of both microbial and host nucleic acids in clinical samples. However, analytical approaches for interpreting complex mNGS datasets are seldom disclosed, limiting advancements in multimodal analysis and omics-driven research models built upon mNGS results. We …

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Diagnosis and Treatment of Severe Acute Sepsis Caused by Burkholderia pseudomallei Infection: A Case Report and Literature Review

Bo Zhu, Yuqing Chen, Lingjun Yuan, Jieting Zhou et autres

Melioidosis, caused by Burkholderia pseudomallei , is a tropical infectious disease with diverse clinical manifestations, which can rapidly progress to acute sepsis and multiorgan failure with high mortality. Here, we report a 45-year-old male who presented with fever, cough, and left lower …

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International multicenter development of ensemble machine learning driven host response based diagnosis for tuberculosis

Shufa Zheng, Wenxin Qu, Dan Zhang, Jieting Zhou et autres

= 1,786) comprising both children and adults from seven countries. Thus, our data demonstrates that TB-Scope provides a powerful and reliable tool for accurately diagnosing ATB across diverse data platforms.

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Utility of clinical metagenomics in complex infections: Cryptococcal meningitis complicated by Nocardia brain abscess

Lingjun Yuan, Yuqing Chen, Mengxiao Xie, Jingchao Wang et autres

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Metagenomic Analysis of Bronchoalveolar Lavage Fluid Enables Differential Diagnosis Between Lung Cancer and Pulmonary Infections

Yu Chen, Dongsheng Han, Fei Yu, Bin Yang et autres

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Pyroptosis-related gene signature: A predictor for overall survival, immunotherapy response, and chemosensitivity in patients with pancreatic adenocarcinoma

Jieting Zhou, Fan Jian, Binxiao Li, Jiayu Sun et autres

Background: Pancreatic adenocarcinoma (PAAD) is a lethal malignancy with high levels of heterogeneity. Pyroptosis is thought to influence the development of various tumors. Nevertheless, the role of pyroptosis-related genes (PRGs) in prognostic risk stratification and therapeutic guidance for PAAD remains ambiguously. Methods: …

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Secondary Infection Surveillance with Metagenomic Next-Generation Sequencing in COVID-19 Patients: A Cross-Sectional Study

Renke Chen, Mengxiao Xie, Shenlong Wang, Fei Yu et autres

Background: Metagenomic next-generation sequencing (mNGS) is a promising tool for improving antimicrobial therapy and infection control decision-making in complex infections. Secondary infection surveillance using mNGS in COVID-19 patients has rarely been reported. Methods: Respiratory pathogen and antibiotic resistance prediction were evaluated by …

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The Real-World Clinical Impact of Plasma mNGS Testing: an Observational Study

Dongsheng Han, Fei Yu, Dan Zhang, Qing Yang et autres

In this study, we show that although plasma mNGS testing significantly improved the detection rate of tested samples, nearly one in four (24.5%, 48/196) mNGS tests reported organisms were not clinically relevant, emphasizing the importance of cautious interpretation and infectious disease consultation. …

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