Yixian Guo

Optimization of Minocycline‐Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Randomized Controlled Trial

Yanan Gao, Yu Huang, Jinnan Chen, Shuhan Qiu et autres

ABSTRACT Background and Aim Minocycline‐containing bismuth quadruple therapy may provide a practical option for Helicobacter pylori ( H. pylori ) rescue treatment when tetracycline is unavailable, yet the optimal dosing remains unclear. We aimed to compare the efficacy and safety of different …

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Helicobacter pylori VacA suppresses HMOX1-driven ferroptosis via the KEAP1/NRF2 axis in gastric cancer

Yixian Guo, Jinnan Chen, Yu Huang, Yaqin Yuan et autres

Helicobacter pylori (H. pylori), one of the main predisposing factors for the development of gastric cancer (GC), is a key factor affecting intracellular ROS and iron metabolism. Ferroptosis is characterized by iron-dependent regulated cell death resulting from excessive lipid peroxidation and is …

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Vonoprazan-amoxicillin dual, rifabutin-based triple, and bismuth quadruple therapies for Helicobacter pylori rescue treatment: a multicentre, open-label, non-inferiority randomised trial

Yu Huang, Jin-Nan Chen, Shu-Han Qiu, Yixian Guo et autres

Background Whether vonoprazan-amoxicillin dual therapy (VA) or rifabutin-based triple study (VRA) can replace bismuth quadruple therapy (BQT) for Helicobacter pylori rescue treatment remains unclear. We aimed to evaluate the efficacy and safety of 10-day VA and VRA regimens, compared with BQT, for …

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Optimization of Minocycline‐Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Real‐World Evidence Study

Yü Huang, Shuhan Qiu, Yixian Guo, Meixuan Li et autres

ABSTRACT Background The optimal dosage of minocycline remains unclear for Helicobacter pylori (H. pylori) eradication. We aimed to evaluate the efficacy and safety of four different regimens with minocycline and metronidazole compared to classical bismuth quadruple therapy for H. pylori rescue treatment. …

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Vonoprazan–Amoxicillin Dual Therapy With Different Amoxicillin Administration Regimens for Helicobacter pylori Treatment: A Randomized Controlled Trial

Shuhan Qiu, Yu Huang, Yixian Guo, Meixuan Li et autres

BACKGROUND: The effect of preprandial or postprandial administration of amoxicillin on the efficacy of vonoprazan-amoxicillin dual therapy (VA-dual therapy) for Helicobacter pylori treatment has not been studied. It is also unclear whether amoxicillin dosing four times daily is more effective than three …

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Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

Hua Li, Yi-Po Ma, Hailong Wang, Caijuan Tian et autres

BACKGROUND The ubiquitin-proteasome pathway (UPP) has been proven to play important roles in cancer. AIM To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these genes. METHODS …

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Increased infiltration of CD4+IL‐17A+FOXP3+ T cells in Helicobacter pylori‐induced gastritis

Yixian Guo, Yu Huang, Shouyu Ke, Feng Xie et autres

Abstract Helicobacter pylori is one of the main predisposing factors for gastric cancer, causing chronic inflammation and proper glands atrophy in the gastric mucosa. Although H. pylori‐induced inflammation is a key inducer of precancerous lesions in the gastric mucosa, it remains unclear …

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CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer

Shouyu Ke, Lei Yi, Yixian Guo, Feng Xie et autres

Abstract Objectives Regulatory T (Treg) cells regulate immunity in autoimmune diseases and cancers. However, immunotherapies that target tumor‐infiltrating Treg cells often induce unwanted immune responses and tissue inflammation. Our research focussed on exploring the expression pattern of CD177 in tumor‐infiltrating Treg cells …

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Staging of operative link on gastritis assessment and operative link on gastric intestinal metaplasia systems for risk assessment of early gastric cancer: a case–control study

Yu Huang, Yixian Guo, Zhaohui Ding, Liang Xiao et autres

Aims Operative link on gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) systems are histological staging systems of gastritis for gastric cancer (GC) risk estimation. Intermediate OLGA/OLGIM stages are of concern in a region with high incidence of …

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Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells

Yixian Guo, Feng Xie, Xu Liu, Shouyu Ke et autres

The enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been recognized as one of the major factors in the initiation and development of resistance to immune checkpoint inhibitors. C-C motif chemokine receptor 8 (CCR8), a marker of activated …

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SIGLEC10+ macrophages drive gastric cancer progression by suppressing CD8+ T cell function

Yixian Guo, Shouyu Ke, Feng Xie, Jieqiong Chen et autres

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CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer

Danhua Xu, Xu Liu, Shouyu Ke, Yixian Guo et autres

BACKGROUND: Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors …

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