Shouyu Ke

Helicobacter pylori VacA suppresses HMOX1-driven ferroptosis via the KEAP1/NRF2 axis in gastric cancer

Yixian Guo, Jinnan Chen, Yu Huang, Yaqin Yuan et autres

Helicobacter pylori (H. pylori), one of the main predisposing factors for the development of gastric cancer (GC), is a key factor affecting intracellular ROS and iron metabolism. Ferroptosis is characterized by iron-dependent regulated cell death resulting from excessive lipid peroxidation and is …

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Adipocyte-derived LTB4 programs human NKG2A + γδ T cells as cytotoxic sentinels at the adipose-tumor interface in breast cancer

Xiaoxiao Hu, Dang Wu, Fang Jia, Sangsang Zhu et autres

Background The peritumoral microenvironment has emerged as a key role in affecting tumor invasion and immunotherapy responses. In adipose-enriched tumors, such as breast cancer (BC), peritumoral adipose tissue (PA) harbors unconventional immune populations, yet its immunological functions remain poorly understood. In particular, …

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Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study

Zhihao Fang, Guohong Ren, Shouyu Ke, Qimin Xu et autres

BACKGROUND: Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC), providing crucial benefits in tumor downstaging. Clinical parameters, such as molecular subtypes, influence the therapeutic impact of NACT. Moreover, severe adverse events delay the treatment process …

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Increased infiltration of CD4+IL‐17A+FOXP3+ T cells in Helicobacter pylori‐induced gastritis

Yixian Guo, Yu Huang, Shouyu Ke, Feng Xie et autres

Abstract Helicobacter pylori is one of the main predisposing factors for gastric cancer, causing chronic inflammation and proper glands atrophy in the gastric mucosa. Although H. pylori‐induced inflammation is a key inducer of precancerous lesions in the gastric mucosa, it remains unclear …

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FOXP3+ regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity

Xinnan Liu, Weiqi Zhang, Yichao Han, Hao Cheng et autres

Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke an anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 and STAT1 are interferon-induced genes that play a positive role in the progression of …

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CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer

Shouyu Ke, Lei Yi, Yixian Guo, Feng Xie et autres

Abstract Objectives Regulatory T (Treg) cells regulate immunity in autoimmune diseases and cancers. However, immunotherapies that target tumor‐infiltrating Treg cells often induce unwanted immune responses and tissue inflammation. Our research focussed on exploring the expression pattern of CD177 in tumor‐infiltrating Treg cells …

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Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells

Yixian Guo, Feng Xie, Xu Liu, Shouyu Ke et autres

The enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been recognized as one of the major factors in the initiation and development of resistance to immune checkpoint inhibitors. C-C motif chemokine receptor 8 (CCR8), a marker of activated …

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SIGLEC10+ macrophages drive gastric cancer progression by suppressing CD8+ T cell function

Yixian Guo, Shouyu Ke, Feng Xie, Jieqiong Chen et autres

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CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer

Danhua Xu, Xu Liu, Shouyu Ke, Yixian Guo et autres

BACKGROUND: Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors …

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A novel small molecule glycolysis inhibitor WZ35 exerts anti-cancer effect via metabolic reprogramming

Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao et autres

BACKGROUND: Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and diagnose liver cancer early and prolong the survival rate is still the focus of …

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High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer

Shouyu Ke, Feng Xie, Yixian Guo, Jieqiong Chen et autres

Immunotherapy targeting glucocorticoid-induced TNFR-related protein (GITR) exhibited strong anti-tumor capacity in mouse model but poor efficacy in clinical trials. This may be attributed to the different GITR expression mode between human and mouse. In this study, we analyzed single-cell RNA sequencing (scRNA-seq) …

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FOXP3+ regulatory T cells and the immune escape in solid tumours

Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin et autres

FOXP3+ regulatory T (Treg) cells play critical roles in establishing the immunosuppressive tumour microenvironment, which is achieved and dynamically maintained with the contribution of various stromal and immune cell subsets. However, the dynamics of non-lymphoid FOXP3+ Treg cells and the mutual regulation …

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