Caijuan Tian

Single-cell transcriptomics reveals the hemocyte atlas and molecular mechanisms underlying the growth-immunity trade-off in Litopenaeus vannamei

Panpan Niu, Shanshan Jiang, Caijuan Tian, Hao Zhong et autres

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Effects of WSSV single infection or co-infection with Vibrio parahaemolyticus on the muscle quality and tissue structure of the ridgetail white prawn, Exopalaemon carinicauda (Decapoda, Caridea, Palaemonidae)

Fei Yu, Caijuan Tian, Hao Zhong, Panpan Wang et autres

Abstract To elucidate the effects of pathogenic infection on the muscle quality and tissue structure of the shrimp, we explored the changes in muscle tissue quality and structure of the ridgetail white prawn (Exopalaemon carinicauda) after infection with Vibrio parahaemolyticus, WSSV, and …

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Effects of Low-Salinity Stress on Histology and Metabolomics in the Intestine of Fenneropenaeus chinensis

Caijuan Tian, Qiong Wang, Tian Gao, Huarui Sun et autres

Metabolomics has been used extensively to identify crucial molecules and biochemical effects induced by environmental factors. To understand the effects of acute low-salinity stress on Fenneropenaeus chinensis, intestinal histological examination and untargeted metabonomic analysis of F. chinensis were performed after exposure to …

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Genome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis

Chenhui Guan, Yalun Li, Qiong Wang, Jiajia Wang et autres

BACKGROUND: Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy plays a pivotal role in both viral infection and replication processes. …

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Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

Hua Li, Yi-Po Ma, Hailong Wang, Caijuan Tian et autres

BACKGROUND The ubiquitin-proteasome pathway (UPP) has been proven to play important roles in cancer. AIM To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these genes. METHODS …

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Genome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis

Chenhui Guan, Yalun Li, Qiong Wang, Jiajia Wang et autres

Abstract Background Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy plays a pivotal role in both viral infection and replication …

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Integrated Analysis of the Intestinal Microbiota and Transcriptome of Fenneropenaeus chinensis Response to Low-Salinity Stress

Caijuan Tian, Qiong Wang, Jiajia Wang, Jitao Li et autres

Salinity is an important environmental stress factor in mariculture. Shrimp intestines harbor dense and diverse microbial communities that maintain host health and anti-pathogen capabilities under salinity stress. In this study, 16s amplicon and transcriptome sequencing were used to analyze the intestine of …

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Prognostic prediction of systemic immune-inflammation status for patients with colorectal cancer: a novel pyroptosis-related model

Jun Hu, Caijuan Tian, Yanpeng Zhao, Yixian Guo et autres

Pyroptosis and related gasdermin family proteins play an important role in the tumorigenesis of colorectal cancer (CRC). However, the prognostic roles of pyroptosis-related genes (PRGs) and their relation to infiltrates of immune cells in the pathogenesis of CRC remain unclear. Using this …

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Molecular Mechanisms and Differences in Lynch Syndrome Developing into Colorectal Cancer and Endometrial Cancer Based on Gene Expression, Methylation and Mutation Analysis

Hongfeng Li, Liwei Sun, Yan Zhuang, Caijuan Tian et autres

Abstract Purpose The aim of this study was to screen biomarkers specific to Lynch syndrome (LS) with colorectal cancer (CRC) or endometrial cancer (EC) to explore the mechanisms by which LS develops into CRC and EC and their differences. Methods Differentially expressed …

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Novel mutation signatures in the prognosis of EGFR-TKIs targeted therapy for non-small cell lung cancer patients based on the 1000-gene panel sequencing

Hui Zhang, Da Jiang, Hui Jin, Yanzhi Cui et autres

The application of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) may be affected by somatic mutations. The purpose of this study was to explore the effect of mutations on the prognosis and tumor markers …

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Identification of Potential Biomarkers for Liver Cancer Through Gene Mutation and Clinical Characteristics

Yunlong Cui, Hua Li, Hongjie Zhan, Tao Han et autres

Liver cancer is a common malignant tumor worldwide, which is a serious threat to the health of people. We try to investigate some mutations and clinical indicators as candidate markers for the development of liver cancer through targeted region capture technology combined …

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Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis

Yan Zhuang, Hailong Wang, Da Jiang, Ying Li et autres

BACKGROUND: Identifying gene mutation signatures will enable a better understanding for the occurrence and development of colorectal cancer (CRC), and provide some potential biomarkers for clinical practice. Currently, however, there is still few effective biomarkers for early diagnosis and prognostic judgment in …

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