Darin Adra

Differential Circulating Proteomic Responses Associated with Ancestry during Severe COVID-19 Infection

Thomas M Zheng, Yann Ilboudo, Tianyuan Lu, Guillaume Butler‐Laporte et autres

COVID-19 led to a disruption in nearly all aspects of society, yet these impacts were not the same across populations. During the pandemic, it became apparent that ancestry was associated with COVID-19 severity and morbidity. This study examines the differential circulating protein …

us, ca, jp, gb (code pays fourni par la source)

Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease

Satoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini et autres

Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins mediating the effects of obesity on coronary artery disease, stroke and type …

us, jp, ca, gb, se, de (code pays fourni par la source)

Differential circulating proteomic responses associated with ancestry during severe COVID-19 infection

Thomas M Zheng, Yann Ilboudo, Tianyuan Lu, Guillaume Butler‐Laporte et autres

Abstract Background COVID-19 led to a disruption in nearly all aspects of society, yet these impacts were not the same across populations. During the pandemic, it became apparent that ancestry was associated with COVID-19 severity and morbidity, such that individuals of African …

ca, jp, us, gb (code pays fourni par la source)

INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE

S. Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini et autres

Alternative splicing in lung influences COVID-19 severity and respiratory diseases

Tomoko MAKINO NAKANISHI, Julian Willett, Yossi Farjoun, Richard J. Allen et autres

Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and susceptibility by applying two-sample Mendelian randomization to cis-splicing quantitative trait loci and the results from COVID-19 Host …

jp, ca, gb (code pays fourni par la source)

INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE

S. Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini et autres

THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis

Satoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini et autres

Abstract Disclosure: S. Yoshiji: None. T. Lu: Employee; Self; 5 Prime Sciences. G. Butler-Laporte: None. J. Carrasco-Zanini-Sanchez: None. Y. Chen: None. K. Liang: None. J.D. Willett: None. C. Su: None. S. Wang: Employee; Self; SomaLogic. D. Adra: None. Y. Ilbudo: None. S. …

ca, gb, us, se (code pays fourni par la source)

COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysis

Satoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini et autres

Abstract Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity has broad effects on circulating protein levels, we investigated circulating proteins that mediate the effects of obesity on coronary …

jp, ca, gb, us, se, de (code pays fourni par la source)

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative, COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak et autres

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative 1 . Here we present …

us, fi, pl, be, ca, jp (code pays fourni par la source)

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, Alex Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

gb, au, cn, ca, ie, us, hk, Ouganda, br (code pays fourni par la source)

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui et autres

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an …

us (code pays fourni par la source)

Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha S. Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx (code pays fourni par la source)