Feng Wang

Covalent Stabilizers of the Interaction Between 14-3-3σ and Estrogen Receptor-α

Rama Jain, Mark Knapp, Sarah E. Kochanek, Adam Lewis et autres

Abstract Selective stabilization of complexes formed by the hub protein 14-3-3 represents an emerging mechanism for the modulation of therapeutically relevant targets. In this letter, we describe a hit-finding campaign designed to identify small molecule stabilizers of the interaction between 14-3-3σ and …

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HD-ZIP transcription factors: pivotal regulators of plant reproductive development

Jiakun Zheng, Feng Wang, Yingxiao Mai, Xingling Su et autres

The HD-ZIP gene family, a group of plant-specific transcription factors, plays pivotal regulatory roles in various aspects of plant growth and development. Accumulating evidence has demonstrated the extensive involvement of HD-ZIP members in regulating reproductive developmental processes. This review systematically summarizes both …

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Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer

Yonghui Zhang, Chen Wang, Xiyang Zhang, Dilong Chen et autres

Background Non-small cell lung cancer (NSCLC) is a common malignancy with limited efficacy of established therapies and a poor prognosis that often entails a high financial burden. Eupatorium lindleyanum DC. and its main component Eupalinolide A (EA) are clinically used for the …

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Formulation of papain-synthetic oligopeptide O(F-r-E) and O(F-r-K) for enhancing pH tolerance of high internal phase emulsions

Feng Wang, Jinyu Cui, Jian Ren Lu, Mengjie Zhang et autres

Integrated cofactor-centric engineering and energy flux optimization enable high-efficient d-pantothenic acid production in Escherichia coli

Yihong Wang, Junping Zhou, Feng Wang, Xinyuan Xin et autres

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Sustainable antibiotic-free high-yield 1,4-butanediol production by engineered aldehyde dehydrogenase and carbon flux remodeling in Escherichia coli

Changyuan Yu, Junping Zhou, Yuanyuan Chen, Feng Wang et autres

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Alleviating Substrate Inhibition of Leucine Dehydrogenase by Enhancing NAD+ Dissociation Efficiency

Yinan Xue, Feng Wang, Hui Gao, Zhicheng Zhang et autres

ABSTRACT Leucine dehydrogenase catalyzes the asymmetric reductive amination of ketoacids to produce valuable chiral unnatural amino acids, but its application is often constrained by substrate inhibition. Here we employed a rational engineering strategy to alleviate substrate inhibition by enhancing the dissociation efficiency …

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miRNA Differential Expression Profile Analysis and Identification of Potential Key Genes in Active Tuberculosis

Hanliang Dan, Yeng Chen, Shanshan Liu, Feng Wang et autres

Tuberculosis (TB), caused by Mycobacterium TB (MTB), remains a significant global health issue, particularly in developing nations. MicroRNAs (miRNAs) are non-coding RNAs (ncRNAs) that modulate immune responses and play a pivotal role in the pathogenesis of MTB by altering host immune defences. …

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The activity regulation of lipase from Aspergillus fumigatus by ligand through allosteric exploration

Feng Wang, Kang Kang, Mengjie Zhang, Keith Fraser et autres

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A framework for dynamic assessment of soil erosion and detection of driving factors in alpine grassland ecosystems using the RUSLE-InVEST (SDR) model and Geodetector: A case study of the source region of the Yellow River

Hucheng Li, Jianjun Chen, Ming Ling, Zizhen Chen et autres

Understanding the spatiotemporal patterns and key drivers of soil erosion in alpine grassland regions is crucial for developing effective conservation and restoration strategies in ecologically vulnerable areas. This study focuses on the source region of the Yellow River (SRYR). It evaluated the …

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Microtubule-Associated Protein 9 Is a Potential Tumor Suppressor That Is Inactivated by Methylation in Cervical Cancer

Pei Li, Feng Wang, Yuhai Gao, Wen Zhang et autres

Abstract Cervical cancer is a malignant disease that seriously affects women’s health, and the cause of cervical cancer is complex. Microtubule-associated protein 9 (MAP9) localizes to the mitotic spindle and it plays an important role in spindle assembly and centrosome integrity maintenance. …

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Effect of Quercetin on Fecal Syndecan-2 Gene Methylation Levels in Patients with Colorectal Cancer and Its Potential Mechanism of Action

Nanyang Li, Xuejun Zhang, Chunmei Li, Feng Wang et autres

Colorectal cancer (CRC) is a relatively common malignant tumor of the digestive system. In this research, the impact of quercetin (Que) on fecal syndecan-2 (SDC2) gene methylation levels in CRC patients and its potential mechanisms of action were analyzed. Retrospective analysis was …

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