Joost W. Gouw

Comparative in vitro digestibility of human milk and infant formulas: In-depth simulation of macronutrient breakdown and gut microbiota response

Joaquim Calvo-Lerma, Christine Bäuerl, Simona Arena, Valentina Ciaravolo et autres

Breastfeeding practices are often impeded by multifactorial circumstances, leading to the need for infant formulas. Previous studies have determined the differences in performance between human milk (HM) and infant formulas (IFs) in terms of macronutrient digestibility, impact on colonic microbiota, and immunomodulatory …

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The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches

Jing Zhu, Julia Bauzá‐Martinez, Joost W. Gouw, Xianfeng Zhao et autres

Human milk lactoferrin (hmLF), a sialic acid-rich iron-binding milk glycoprotein, is essential for infant development, playing a key role in immune defense and gut maturation. Despite its importance, the diversity of hmLF proteoforms, including the relationship between glycosylation profiles (glycoforms) and iron-binding …

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Characterization of Extracellular Vesicles from Streptococcus thermophilus 065 and Their Potential to Modulate the Immune Response

Angela Rocio Ortiz Camargo, Oscar van Mastrigt, Joost W. Gouw, Yue Liu et autres

Bacteria can release membrane-derived nanoparticles made of lipid bilayers, so-called extracellular vesicles (EVs), which can carry diverse cargo and are important for microbe-microbe and microbe-host interactions. Here, we studied the production of EVs by Streptococcus thermophilus 065, the protein composition of the …

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Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk

Simona Arena, Sabrina De Pascale, Valentina Ciaravolo, Mariela Mejia Monroy et autres

The role of the Maillard reaction and the accumulation of non-enzymatic glycation compounds in human milk have been scarcely considered. In this study, we investigated the proteins most susceptible to glycation, the identity of the corresponding modified residues and the quantitative relationship …

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Glycation Compounds in Human Milk

Simona Arena, Sabrina De Pascale, Valentina Ciaravolo, Mariela Mejia Monroy et autres

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Metaproteomic and 16S rRNA Gene Sequencing Analysis of the Infant Fecal Microbiome

Laetitia Cortes, Harm Wopereis, Aude Tartiere, Julie Piquenot et autres

A metaproteomic analysis was conducted on the fecal microbiome of eight infants to characterize global protein and pathway expression. Although mass spectrometry-based proteomics is now a routine tool, analysis of the microbiome presents specific technical challenges, including the complexity and dynamic range …

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Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula

Joost W. Gouw, Juandy Jo, Laura A.P.M. Meulenbroek, T. Sam Heijjer et autres

Summary Background Failure to induce oral tolerance may result in food allergy. Hydrolysed cow's milk‐based infant formulas are recommended in subjects with a high risk of developing allergic disease. Presentation of T cell epitopes is a prerequisite to generate regulatory T cells …

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A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections

Rosana B. R. Ferreira, Yanet Valdez, Brian K. Coombes, Subash Sad et autres

UNLABELLED: Nontyphoidal Salmonella enterica (NTS) infections are a major burden to global public health, as they lead to diseases ranging from gastroenteritis to systemic infections and there is currently no vaccine available. Here, we describe a highly effective component vaccine against S. …

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Response of the honey bee (Apis mellifera) proteome to Israeli acute paralysis virus (IAPV) infection

Sarah A. Michaud, Humberto Boncristiani, Joost W. Gouw, Micheline K. Strand et autres

Recent declines in honey bee (Apis mellifera L., 1758) populations worldwide have spurred significant research into the impact of pathogens on colony health. The role of the Israeli acute paralysis virus (IAPV) on hive mortality has become of particular concern since being …

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A Horizontally Acquired Transcription Factor Coordinates Salmonella Adaptations to Host Microenvironments

Nat F. Brown, Lindsay D. Rogers, Kristy L. Sanderson, Joost W. Gouw et autres

UNLABELLED: The transcription factors HilA and SsrB activate expression of two type III secretion systems (T3SSs) and cognate effectors that reprogram host cell functions to benefit infecting Salmonella in the host. These transcription factors, the secretion systems, and the effectors are all …

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Connexin multi-site phosphorylation: Mass spectrometry-based proteomics fills the gap

Vincent C. Chen, Joost W. Gouw, Christian C. G. Naus, Leonard J. Foster

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Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site

Qian Ren, Qing S. Wang, Andrew E. Firth, Mandy M. Y. Chan et autres

The dicistrovirus intergenic region internal ribosome entry site (IRES) utilizes a unique mechanism, involving P-site tRNA mimicry, to directly assemble 80S ribosomes and initiate translation at a specific non-AUG codon in the ribosomal A site. A subgroup of dicistrovirus genomes contains an …

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