Lindsay D. Rogers

What Does CLARITY-BPA Mean for Canadians?

Lindsay D. Rogers

Bisphenol A is an extremely high-volume chemical widely used in polycarbonate plastics, the linings of food and beverage tins, and shopping receipts. Canadians are ubiquitously exposed to bisphenol A and research shows that exposure at environmentally relevant doses causes endocrine disruption. Recent …

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Interactome disassembly during apoptosis occurs independent of caspase cleavage

Nichollas E. Scott, Lindsay D. Rogers, Anna Prudova, Nat F. Brown et autres

Protein-protein interaction networks (interactomes) define the functionality of all biological systems. In apoptosis, proteolysis by caspases is thought to initiate disassembly of protein complexes and cell death. Here we used a quantitative proteomics approach, protein correlation profiling (PCP), to explore changes in …

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iRhom2 regulates CSF1R cell surface expression and non‐steady state myelopoiesis in mice

Xiaoping Qing, Lindsay D. Rogers, Arthur Mortha, Yonit Lavin et autres

CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major …

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LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

Pitter F. Huesgen, Philipp F. Lange, Lindsay D. Rogers, Nestor Solis et autres

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A Horizontally Acquired Transcription Factor Coordinates Salmonella Adaptations to Host Microenvironments

Nat F. Brown, Lindsay D. Rogers, Kristy L. Sanderson, Joost W. Gouw et autres

UNLABELLED: The transcription factors HilA and SsrB activate expression of two type III secretion systems (T3SSs) and cognate effectors that reprogram host cell functions to benefit infecting Salmonella in the host. These transcription factors, the secretion systems, and the effectors are all …

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Proteolytic Post-translational Modification of Proteins: Proteomic Tools and Methodology

Lindsay D. Rogers, Christopher M. Overall

Proteolytic processing is a ubiquitous and irreversible post-translational modification involving limited and highly specific hydrolysis of peptide and isopeptide bonds of a protein by a protease. Cleavage generates shorter protein chains displaying neo-N and -C termini, often with new or modified biological …

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Global Impact of Salmonella Pathogenicity Island 2-secreted Effectors on the Host Phosphoproteome

Koshi Imami, Amit P. Bhavsar, Hongbing Yu, Nat F. Brown et autres

During the late stages of infection, Salmonella secretes numerous effectors through a type III secretion system that is encoded within Salmonella pathogenicity island 2 (SPI2). Despite the importance of SPI2 as a major virulence factor leading to the systemic spread of the …

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Phosphoproteomic Analysis of Salmonella -Infected Cells Identifies Key Kinase Regulators and SopB-Dependent Host Phosphorylation Events

Lindsay D. Rogers, Nat F. Brown, Fang Yuan, Steven Pelech et autres

Salmonella enterica is a bacterial pathogen that causes gastroenteritis and typhoid fever. Virulence is achieved by two type III secretion systems that translocate effector proteins into host cells, where they mimic or block host protein function. Effectors translocated into host cells by …

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Quantitative Mass Spectrometry Catalogues Salmonella Pathogenicity Island-2 Effectors and Identifies Their Cognate Host Binding Partners

Sigrid Auweter, Amit P. Bhavsar, Carmen L. de Hoog, Yuling Li et autres

Gram-negative bacterial pathogens have developed specialized secretion systems to transfer bacterial proteins directly into host cells. These bacterial effectors are central to virulence and reprogram host cell processes to favor bacterial survival, colonization, and proliferation. Knowing the complete set of effectors encoded …

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Proteomic analysis of Salmonella-host interactions reveals novel host targets of SopB

Lindsay D. Rogers

Salmonella enterica is an intracellular bacterium causing gastroenteritis and typhoid fever. Virulence is achieved by two type III secretion systems (T3SS) encoded on Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) that translocate effector proteins into host cells where they mimic …

An integrated global strategy for cell lysis, fractionation, enrichment and mass spectrometric analysis of phosphorylated peptides

Lindsay D. Rogers, Yuan Fang, Leonard J. Foster

Recently, the field of phosphoproteomics has progressed to the point where thousands of protein phosphorylations can be analyzed simultaneously and used to address significant biological questions. However, several challenges still exist in current LC-MS/MS-based phosphoproteomics methods. Among these are the increased dynamic …

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Phosphoproteomics—finally fulfilling the promise?

Lindsay D. Rogers, Leonard J. Foster

Networks of protein-protein and protein-metabolite interactions are commonly found in biological systems where signals must be passed from one location or component within a cell to another, such as from a receptor on the plasma membrane to a transcription factor in the …

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