Response of the honey bee (Apis mellifera) proteome to Israeli acute paralysis virus (IAPV) infection
Rattachement africain : ca, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Recent declines in honey bee (Apis mellifera L., 1758) populations worldwide have spurred significant research into the impact of pathogens on colony health. The role of the Israeli acute paralysis virus (IAPV) on hive mortality has become of particular concern since being correlated with colony losses. However, the molecular interactions between IAPV and its host remain largely unknown. To investigate changes in host protein expression during IAPV infection, mass-spectrometry-based quantitative proteomics was used to compare IAPV-infected and healthy pupae. Proteins whose expression levels changed significantly during infection were identified and functional analysis was performed to determine host systems and pathways perturbed by IAPV infection. Among the A. mellifera proteins most affected by IAPV, those involving translation and the ubiquitin–proteasome pathway were most highly enriched and future investigation of these pathways will be useful in identifying host proteins required for infection. This analysis represents an important first step towards understanding the honey bee host response to IAPV infection through the systems-level analysis of protein expression.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Response of the honey bee (<i>Apis mellifera</i>) proteome to Israeli acute paralysis virus (IAPV) infection
- Date Crossref
- 01/09/2015
- Éditeur
- Canadian Science Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of British Columbia Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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High Throughput Biology (United States) pays non établi dans la noticeEntreprise
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University of North Carolina at Greensboro Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Triangle pays non établi dans la noticeOrganisation à but non lucratif
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United States Department of Agriculture pays non établi dans la noticeOrganisme public
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Beltsville Agricultural Research Center pays non établi dans la noticeStructure de recherche
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Life Sciences Division pays non établi dans la noticeInstitution
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Bee Research Laboratory US Department of Agriculture – Agricultural Research Service pays non établi dans la noticeStructure de recherche
Department of Biochemistry and Molecular Biology — University of British Columbia, High Throughput Biology (United States) et Department of Biology — University of North Carolina at Greensboro, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.