Alan S. Lader

P-101. A Phase 3 International, Multi-Center, Randomized, Open-Label, Assessor-Blind Study to Evaluate the Efficacy and Safety of Minocycline/EDTA/Ethanol (Mino-Lok) Therapy (MLT) vs Site-Specific Antimicrobial Lock in Combination with Systemic Antibiotics in the Treatment of Catheter-Related or Central Line-Associated Bloodstream Infection

Anne‐Marie Chaftari, Vinay Rathore, Ray Y Hachem, Toan T. Huynh et autres

Abstract Background Catheter-related or central line-associated bloodstream infection (CRBSI/CLABSI) causes substantial morbidity and mortality. Managing CRBSI/CLABSI often involves removing the infected central venous catheter (CVC) and inserting a new one at a different vascular site. Currently, no adjunct antimicrobial lock therapy (in …

us, in (code pays fourni par la source)

1463: EFFICACY OF HIGH AND LOW DOSES OF NOVEL PSC-INDUCED MESENCHYMAL STROMAL CELLS IN OVINE ARDS

Kento Homma, Kazuki Hashimoto, Nikolay Bazhanov, Matt Angel et autres

Homma, Kento; Hashimoto, Kazuki; Bazhanov, Nikolay; Angel, Matt; Lader, Alan; Czuczman, Myron; Matthay, Michael; Enkhbaatar, Perenlei Author Information

us (code pays fourni par la source)

Novel induced-mesenchymal stem cells (i-MSCS) attenuate severity of ards in septic sheep

Kazuki Hashimoto, Nikolay Bazhanov, Perenlei Enkhbaatar, Moritz Angel et autres

us (code pays fourni par la source)

SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention

James Enlou Tcheng, Michael Gibson, Mitchell W. Krucoff, Manesh R. Patel et autres

OBJECTIVE: The natural molecule α-lipoic acid has been shown to be partially cytoprotective through antioxidant and antiapoptotic mechanisms. To obtain an initial assessment of the safety and potential efficacy of a synthetic derivative, CMX-2043, in preventing ischemic complications of percutaneous coronary intervention …

us, in (code pays fourni par la source)

CMX-2043 Mechanisms of Action In Vitro

Alan S. Lader, Alexander B. Baguisi, Ralph A. Casale, Steven A. Kates et autres

α-Lipoic acid has been shown to provide cytoprotection in some tissues through antioxidant and antiapoptotic mechanisms. We have enhanced these properties by synthetic modification, resulting in a new chemical entity, CMX-2043, with proven efficacy in an animal model of cardiac ischemia-reperfusion injury. …

CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia–Reperfusion Injury

Alexander B. Baguisi, Ralph A. Casale, Steven A. Kates, Alan S. Lader et autres

α-Lipoic acid (LA) has been shown to offer protection against ischemia-reperfusion injury (IRI) in multiple organ systems. N-[(R)-1,2-dithiolane-3-pentanoyl]-L-glutamyl-L-alanine (CMX-2043), a novel analogue of LA, was studied as part of a preclinical development program intended to identify safe and efficacious drug candidates for …

Pre‐clinical and Clinical Safety Studies of CMX ‐2043: A Cytoprotective Lipoic Acid Analogue for Ischaemia–Reperfusion Injury

Steven A. Kates, Alan S. Lader, Ralph A. Casale, Reinier Beeuwkes

CMX-2043 is an α-lipoic acid analogue targeted to reduction of cellular injury and organ damage due to ischaemia-reperfusion injury (IRI). It has been shown to be effective in a rat model of cardiac IRI. The studies here reported evaluate its safety and …

Crotoxin potentiates L-type calcium currents and modulates the action potential of neonatal rat cardiomyocytes

Peng Zhang, Alan S. Lader, Martin A. Etcheverry, Horacio F. Cantiello

us, ar (code pays fourni par la source)

O-193 Novel semaphorin- and juxtamembrane-domain mutations ofc-MET in NSCLC: Potential for targeted inhibition

Pei Ma, Sascha Dietrich, Edward Fox, Katsuhiko Naoki et autres

Mechanisms of gelsolin-dependent and -independent EGF-stimulated cell motility in a human lung epithelial cell line

Alan S. Lader, Justin J. Lee, Gregor Cicchetti, David J. Kwiatkowski

us (code pays fourni par la source)

Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer

Charkira C. Patrick, Ramasamy Jagadeeswaran, Simha Jagadeesh, Maria Tretiakova et autres

Non-small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an attractive potential target for novel therapeutic inhibition in human cancers. We provide strong evidence that c-Met is overexpressed, activated, and sometimes mutated in NSCLC cell lines …

us (code pays fourni par la source)

A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes

Lynsey M. Meikle, Julie R. McMullen, Megan C. Sherwood, Alan S. Lader et autres

Tuberous sclerosis is a hamartoma syndrome due to mutations in TSC1 or TSC2 in which cardiac rhabdomyomas are seen in approximately 60% of patients. These lesions have an unusual natural history as they are usually most prominent immediately after birth and spontaneously …

us (code pays fourni par la source)