Anne‐Marie Chaftari

Disseminated Aspergillosis with Central Nervous System Involvement Among Patients with Hematologic Malignancies: A 30-Year Institutional Cohort of Clinical Features, Management, and Outcomes

Saliba Wehbe, Ray Y Hachem, Anne‐Marie Chaftari, Amir Melek et autres

Background: Disseminated invasive aspergillosis (IA) is an uncommon but devastating manifestation of disease, particularly when the central nervous system (CNS) is involved. The clinical features and outcomes of CNS dissemination, compared with isolated invasive pulmonary aspergillosis (IPA) and other disseminated forms, remain …

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Antimicrobial elution patterns correlate with antibacterial and antifungal activities of three antimicrobial central venous catheters in serum

ISSAM I. RAAD, Y-Lan Truong, Bahgat Gerges, Yan Jiang et autres

ABSTRACT Antimicrobial central venous catheters (CVCs) help prevent CVC-related bloodstream infection (CRBSI), and their effectiveness depends on sustaining broad antimicrobial activity in serum. A new CVC containing minocycline, rifampin, and chlorhexidine (MRC) was recently approved, complementing existing minocycline-rifampin (MR) and chlorhexidine-silver-sulfadiazine (CSiSz) …

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P-101. A Phase 3 International, Multi-Center, Randomized, Open-Label, Assessor-Blind Study to Evaluate the Efficacy and Safety of Minocycline/EDTA/Ethanol (Mino-Lok) Therapy (MLT) vs Site-Specific Antimicrobial Lock in Combination with Systemic Antibiotics in the Treatment of Catheter-Related or Central Line-Associated Bloodstream Infection

Anne‐Marie Chaftari, Vinay Rathore, Ray Y Hachem, Toan T. Huynh et autres

Abstract Background Catheter-related or central line-associated bloodstream infection (CRBSI/CLABSI) causes substantial morbidity and mortality. Managing CRBSI/CLABSI often involves removing the infected central venous catheter (CVC) and inserting a new one at a different vascular site. Currently, no adjunct antimicrobial lock therapy (in …

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689. Pediatric vs. Adult Invasive Aspergillosis in Cancer and Hematopoietic Stem Cell Transplant Patients: Insights from a Matched Cohort at a Tertiary Cancer Center

Saliba Wehbe, ramia g zakhour, Ray Y Hachem, Hiba Dagher et autres

Abstract Background Invasive aspergillosis (IA) remains the most common invasive mold infection in pediatric and adult patients with cancer or hematopoietic stem cell transplant (HCT), leading to substantial morbidity and mortality. Differences in IA presentation, diagnosis, management, and outcomes between children and …

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P-1052. Impact of Chlorhexidine Elution Profiles on Antifungal Durability of Two Chlorhexidine-Coated Antimicrobial Central Venous Catheters (CVCs)

Y Lan Truong, Joel Rosenblatt, Bahgat Z Gerges, Ying Jiang et autres

Abstract Background The prevalence of Central Line Associated Bloodstream Infections (CLABSIs) due to Candida species continues to increase, hence CVCs with improved antifungal activities are needed. The FDA recently cleared a new antimicrobial CVC containing Chlorhexidine (C), Minocycline (M) and Rifampin (R). …

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P-1051. Antibiotic Elution Patterns Correlate with Antibacterial Activity of Three Antibiotic Antimicrobial Central Venous Catheters (CVCs)

Y Lan Truong, Joel Rosenblatt, Bahgat Z Gerges, Ying Jiang et autres

Abstract Background Central Line Associated Bloodstream Infections (CLABSIs) have been designated “never events” hence CVCs with improved antibacterial activities are needed. The FDA recently cleared a new CVC containing Chlorhexidine (C), Minocycline (M) and Rifampin (R). This makes available a third antibiotic …

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A Prospective Randomised Clinical Study Comparing Polygalacturonic and Caprylic Acid Ointment to Medical‐Grade Honey in the Management of Chronic Wounds

Hiba Dagher, Ray Y Hachem, Christopher Alain Hakim, Rola Husni et autres

The aim in this human trial is to compare the efficacy and safety of polygalacturonic-caprylic acid (PG-CAP) ointment to MediHoney in chronic wounds at three international medical centres. In this prospective open-label study, patients with chronic full-thickness wounds were randomised to daily …

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Pediatric vs. Adult Invasive Aspergillosis in Cancer and Hematopoietic Transplant Patients: Insights from a Matched Cohort at a Tertiary Cancer Center

Saliba Wehbe, ramia g zakhour, Ray Y Hachem, Ying Jiang et autres

Background: Invasive aspergillosis (IA) is a life-threatening infection in immunocompromised patients, including those with hematologic malignancies and hematopoietic stem cell transplants. While adult IA has been well characterized, data on pediatric populations remain limited, and potential age-related differences are often overlooked in …

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Dalbavancin for Treatment of Staphylococcus aureus Bacteremia

Nicholas Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, Thomas P. Lodise et autres

Importance: Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access. Objective: To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S …

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Risk factors for catheter-related bloodstream infections in a high-risk cancer patient population

Andrea Haddad, Rita Wilson Dib, Anne‐Marie Chaftari, Ying Jiang et autres

To identify risk factors for catheter-related bloodstream infections (CRBSI) in cancer patients, we compared 200 CRBSI cases to 400 controls. Neutropenia, transplants, multiple catheters, blood products, and basilic/cephalic PICCs increased CRBSI risk, while jugular insertion was protective. Catheter site selection can reduce …

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Prognostic Value of Serum and Bronchoalveolar Lavage Fluid Galactomannan Levels in Invasive Aspergillosis: An 8-Year Experience at a Tertiary Cancer Center

Saliba Wehbe, Anne‐Marie Chaftari, Ray Y Hachem, Hiba Dagher et autres

Background: Invasive aspergillosis (IA) is a life-threatening fungal infection that primarily affects immunocompromised individuals and has high morbidity and mortality rates, necessitating timely diagnosis and treatment. This study aimed to evaluate the prognostic utility of serum and bronchoalveolar lavage (BAL) fluid galactomannan …

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Prognostic Value of Serum and Bronchoalveolar Lavage Fluid Galactomannan Levels in Invasive Aspergillosis: An 8-Year Experience at a Tertiary Cancer Center

Saliba Wehbe, Anne‐Marie Chaftari, Ray Y Hachem, Hiba Dagher et autres

Background: Invasive aspergillosis (IA) is a life-threatening fungal infection that primarily affects immunocompromised individuals and has high morbidity and mortality rates, necessitating timely diagnosis and treatment. This study aimed to evaluate the prognostic utility of serum and bronchoalveolar lavage (BAL) fluid galactomannan …