SHARE: Building Bioinspired Prototypes using LEGO SERIOUS PLAY
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Charkira C. Patrick
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205Publications signalées
12182Citations signalées
3Affiliations récentes
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Les domaines associés
Lung Cancer Treatments and MutationsLung Cancer Research StudiesElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative MedicineLiver physiology and pathology
Les publications récentes
Lonigutamab inhibits hyaluronan production by reducing IGF-1R levels in thyroid eye disease orbital fibroblasts
Elisa Roztocil, Farha Husain, Charkira C. Patrick, Stephen B Thomas et autres
CONTEXT: In thyroid eye disease (TED), the connective tissue behind the eye becomes inflamed and expands, partly due to excessive deposition of hyaluronan (HA), which absorbs water, leading to osmotic swelling. Orbital fibroblasts (OFs) from patients with TED overexpress insulin-like growth factor …
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The Journal of Clinical Endocrinology & Metabolism
Scaffolding Inquiry-Based Learning in Nature-Inspired Medical Device Design
Abstract Challenge Biomimicry, biomimetic, and bioinspired (B 3 ) approaches to medical device and technology design are a broad and multidisciplinary framework for engineering design. A typical final design assignment for a semester-long design course requires students to apply course knowledge and …
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1 citation
Biomedical Engineering Education
WIP: Workforce Development and Student Success Through the Hidden Curriculum
Charkira C. Patrick, Travis Carrell, Annie Hedman, John D. Horn et autres
This Research-to-Practice and Work-in-Progress paper discusses the development, deployment, and assessment of a hidden curriculum resource in a biomedical engineering department. A student-centric, faculty-driven hidden curriculum was rooted in social and situated learning theories and developed according to Kotter's change model. The …
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Metformin inhibits PDGF signaling to suppress hyaluronan and IL-6 production in Thyroid Eye Disease
Farha Husain, Charkira C. Patrick, Elisa Roztocil, Steven E. Feldon et autres
ABSTRACT Background Thyroid eye disease (TED) is a debilitating autoimmune disorder affecting 25-50% of patients with Graves’ disease. TED is characterized by inflammation and tissue remodeling of orbital tissues. Orbital fibroblasts (OFs) and platelet-derived growth factor (PDGF) signaling promote tissue remodeling in …
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bioRxiv (Cold Spring Harbor Laboratory)
Integrated Molecular and Clinical Characterization of Pulmonary Large Cell Neuroendocrine Carcinoma
Anne C. Chiang, Amin H. Nassar, Chul Kim, Tolulope Tosin Adeyelu et autres
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Research Square
Correction: Enhancing Student Engagement in the Graduate Seminar by Scaffolding Active Learning Activities
Elizabeth A. Bullard, Christina R. Dubell, Charkira C. Patrick, Frances S. Ligler et autres
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Biomedical Engineering Education
Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease
Elisa Roztocil, Farha Husain, Charkira C. Patrick, Steven E. Feldon et autres
Background:Thyroid eye disease (TED) is an autoimmune disorder characterized by proptosis, inflammation, and fibrosis. Elevated insulin-like growth factor 1 receptor (IGF1R) signaling in TED orbital fibroblasts (OFs) drives the proliferation and biosynthesis of hyaluronan, which causes enlargement of orbital tissue volume. The …
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6 citations
Thyroid
Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy
Charkira C. Patrick, Elisa Roztocil, Farha Husain, Steven E. Feldon et autres
Purpose: In thyroid eye disease (TED), activation and proliferation of orbital fibroblasts (OFs) promotes remodeling and causes an increase in the volume of orbital tissue. Platelet-derived growth factors (PDGFs) are elevated in TED and promote OF activation. The aryl hydrocarbon receptor (AHR), …
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7 citations
Investigative Ophthalmology & Visual Science
Enhancing Student Engagement in the Graduate Seminar by Scaffolding Active Learning Activities
Elizabeth A. Bullard, Christina R. Dubell, Charkira C. Patrick, Frances S. Ligler et autres
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1 citation
Biomedical Engineering Education
Brief Report: The Immune Profiles of the Molecular Subtypes of EGFR-Mutant Lung Adenocarcinomas in a Large Real-World Cohort
Joseph Nicholas Bodor, Joanne Xiu, Vinicius Ernani, Supreet Kaur et autres
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1 citation
Clinical Lung Cancer
WIP: Conversion of a Biotransport Course From Face-to-Face to Online
WIP: Conversion of a Biotransport Course
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2021 ASEE Virtual Annual Conference Content Access Proceedings
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