Annalisa Roberti

Epigenetic dysregulation of the H3K14ac/H3K9me2 axis is associated with malignant transformation and prognosis in colon adenocarcinoma

Annalisa Roberti, Juan Ramón Tejedor, Claudia Martínez-Sánchez, Virginia López et autres

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The case for primary prevention of obesity in the era of GLP-1 therapies

Soren Holm, Manuel Tena-Sempere, Dimitrios Koutsouris, George V. Dedoussis et autres

Obesity rates continue to rise across Europe, driven by obesogenic environments shaped by food systems, urban design, socioeconomic inequalities, and commercial forces. The introduction of incretin-based pharmacotherapies like GLP-1 receptor agonists has transformed treatment, leading to significant weight loss and metabolic benefits …

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Age-Dependent Effect of Environmental Enrichment on the Neural 3D Chromatin Interactome (datasets and additional files)

Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor, Raúl F. Pérez et autres

Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process, remains limited. Here we performed low input Promoter Capture Hi-C (liCHi-C) …

es, lk (code pays fourni par la source)

DNA methylome analysis reveals distinct episignatures in bicuspid aortic valve

D Bagues-Castro, M Martin, J R Tejedor, A M Barral-Varela et autres

Abstract Background Bicuspid aortic valve (BAV) is the most common congenital heart malformation in the general population, frequently associated with the development of aortic valve diseases and severe aortopathy. There is a great variability in the clinical progression of this anomaly and, …

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6107-7. ANÁLISIS DEL PATRÓN DE METILACIÓN EN VÁLVULA AÓRTICA: EPIFIRMA DIFERENCIAL EN VÁLVULA AÓRTICA BICÚSPIDE

Dario Bagues Castro, María Martín Fernández, Daniel López Fanjul, Juan Ramón Tejedor Vaquero et autres

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome

Javier Gancedo-Verdejo, Rocío González Urdinguio, Juan Ramón Tejedor, Raul Fernandez Perez et autres

Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process remains limited. Here, we describe alterations in the landscape of the …

es, lk (code pays fourni par la source)

Epigenomic Profiling of Histone Posttranslational Modifications in Frozen Cancer Tissue Using CUT&RUN

Annalisa Roberti, Mario Fernández Fraga

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Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments

Javier Gancedo-Verdejo, Rocío González Urdinguio, Juan Ramón Tejedor, Raul Fernandez Perez et autres

ABSTRACT Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process, remains limited. Here we describe alterations in the landscape of …

es, us (code pays fourni par la source)

Spatial control of the APC/C ensures the rapid degradation of cyclin B1

Luca Cirillo, R P Young, Sapthaswaran Veerapathiran, Annalisa Roberti et autres

The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is effected by the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). The SAC prevents …

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A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment

Raul Fernandez Perez, Patricia Tezanos, Alfonso Peñarroya, Alejandro González-Ramón et autres

Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of healthy aging. To evaluate the role of …

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A FokI-driven signal amplification platform for the simultaneous detection of multiple viral RNA pathogens

Juan Ramón Tejedor, Annalisa Roberti, Cristina Mangas, Marta Elena Álvarez‐Argüelles et autres

The combination of a nucleic acid amplification method through multiplexed RCA, coupled with signal amplification mediated by FokI-assisted digestion of dumbbell-like oligonucleotides, enhances the detection of multiple human respiratory viruses.

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CRISPR/dCas9-mediated DNA demethylation screen identifies driver epigenetic determinants of colorectal cancer (Processed data)

Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres

Background: Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is an actual driver of cancer or is a mere consequence of the carcinogenic process remains to be elucidated. …

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