Sapthaswaran Veerapathiran

Spatial control of the APC/C ensures the rapid degradation of cyclin B1

Luca Cirillo, R P Young, Sapthaswaran Veerapathiran, Annalisa Roberti et autres

The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is effected by the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). The SAC prevents …

gb (code pays fourni par la source)

Receptor binding and tortuosity explain morphogen local-to-global diffusion coefficient transition

Shiwen Zhu, Yi Ting Loo, Sapthaswaran Veerapathiran, Tricia Y. J. Loo et autres

Morphogens are intercellular signaling molecules providing spatial information to cells in developing tissues to coordinate cell fate decisions. The spatial information is encoded within long-ranged concentration gradients of the morphogen. Direct measurement of morphogen dynamics in a range of systems suggests that …

sg, gb (code pays fourni par la source)

Receptor binding and tissue architecture explain the morphogen local-to-global mobility transition

Shiwen Zhu, Yi Ting Loo, Sapthaswaran Veerapathiran, Tricia Y. J. Loo et autres

ABSTRACT Morphogens are intercellular signaling molecules providing spatial information to cells in developing tissues to coordinate cell fate decisions. The spatial information is encoded within long-ranged concentration gradients of the morphogen. Direct measurement of morphogen dynamics in a range of systems suggests …

sg, gb (code pays fourni par la source)

Spatial control of the APC/C ensures the rapid degradation of Cyclin B1

Luca Cirillo, R P Young, Sapthaswaran Veerapathiran, Annalisa Roberti et autres

ABSTRACT The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is under the control of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). …

gb (code pays fourni par la source)

Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy

Martina Barbiero, Luca Cirillo, Sapthaswaran Veerapathiran, Catherine Coates et autres

Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address. This considerable gap in our understanding is due to …

gb (code pays fourni par la source)

Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved Fluorescence Correlation Spectroscopy

Martina Barbiero, Luca Cirillo, Sapthaswaran Veerapathiran, Catherine Coates et autres

Abstract Measuring the dynamics with which the regulatory complexes of the cell cycle machinery assemble and disassemble is a crucial barrier to our understanding that until now has been difficult to address. This considerable gap in our understanding is due to the …

gb (code pays fourni par la source)

Wnt3 Is Lipidated at Conserved Cysteine and Serine Residues in Zebrafish Neural Tissue

Divya Dhasmana, Sapthaswaran Veerapathiran, Yagmur Azbazdar, Ashwin V.S. Nelanuthala et autres

Wnt proteins are a family of hydrophobic cysteine-rich secreted glycoproteins that regulate a gamut of physiological processes involved in embryonic development and tissue homeostasis. Wnt ligands are post-translationally lipidated in the endoplasmic reticulum (ER), a step essential for its membrane targeting, association …

sg, tr (code pays fourni par la source)

The Influence of Transfection Methods on the Molecular Dynamics of the Cell Plasma Membrane

Guo Meihui, Thorsten Wholand, Sapthaswaran Veerapathiran

sg (code pays fourni par la source)

Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions

Sapthaswaran Veerapathiran, Cathleen Teh, Shiwen Zhu, Indira Kartigayen et autres

Wnt3 proteins are lipidated and glycosylated signaling molecules that play an important role in zebrafish neural patterning and brain development. However, the transport mechanism of lipid-modified Wnts through the hydrophilic extracellular environment for long-range action remains unresolved. Here we determine how Wnt3 …

sg, pl (code pays fourni par la source)

Author response: Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions

Sapthaswaran Veerapathiran, Cathleen Teh, Shiwen Zhu, Indira Kartigayen et autres

Wnt3 accomplishes long-range distribution by extracellular diffusion controlled by expression, tissue morphology, interactions with heparan sulfate proteoglycans, and co-receptor-mediated receptor binding to regulate brain development in zebrafish embryos.

sg, pl (code pays fourni par la source)

Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions

Sapthaswaran Veerapathiran, Cathleen Teh, Shiwen Zhu, Indira Kartigayen et autres

Abstract Wnt3 proteins are lipidated and glycosylated, secreted signaling molecules that play an important role in zebrafish neural patterning and brain development. However, the transport mechanism of lipid-modified Wnts through the hydrophilic extracellular environment for long-range action remains unresolved. Here, we determine …

sg, pl, fr (code pays fourni par la source)

The Development of a Scoring Rubric for Studying Graduate Teaching Assistants’ Competence in Collaborative Learning Lesson Planning and Implementation

Mark Joo Seng Gan, Sapthaswaran Veerapathiran

Teaching assistants play an important role in teaching and learning in tertiary institutions. In this study, we explore the development and use of a scoring rubric to investigate Graduate Teaching Assistants’ (GTAs) competence in adopting collaborative learning (CL) scripts during a two-day …

sg (code pays fourni par la source)