Accès ouvert
2026
dataset
OpenAlex
Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor, Raúl F. Pérez et autres
Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process, remains limited. Here we performed low input Promoter Capture Hi-C (liCHi-C) …
es, lk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Javier Gancedo-Verdejo, Rocío González Urdinguio, Juan Ramón Tejedor, Raul Fernandez Perez et autres
Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process remains limited. Here, we describe alterations in the landscape of the …
es, lk
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Javier Gancedo-Verdejo, Rocío González Urdinguio, Juan Ramón Tejedor, Raul Fernandez Perez et autres
ABSTRACT Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process, remains limited. Here we describe alterations in the landscape of …
es, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Raul Fernandez Perez, Patricia Tezanos, Alfonso Peñarroya, Alejandro González-Ramón et autres
Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of healthy aging. To evaluate the role of …
es
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Background: Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is an actual driver of cancer or is a mere consequence of the carcinogenic process remains to be elucidated. …
es, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Background: Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is an actual driver of cancer or is a mere consequence of the carcinogenic process remains to be elucidated. …
es, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Abstract Background Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or is a mere consequence of the carcinogenic process remains to be elucidated. Results …
es, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Additional file 2: Table S2. List of differentially methylated CpGs identified in each of the cohorts used in this study.
es, lk, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Additional file 9: Table S8. List of gRNA sequences designed for the epigenetic modulation of genes with robust correlation between DNA methylation and gene expression in CRC samples.
es, lk, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Additional file 3: Table S3. Statistics related to enrichment analyses of common DMPs at TFBS from the GTRD database.
es, lk, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Additional file 6: Table S6. List of CpG sites displaying robust correlation (>0.5 Pearson corr) between DNA methylation and gene expression in TCGA-COAD as calculated by the R/Bioconductor ELMER package.
es, lk, us
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina‐Ojeda et autres
Additional file 15: Table S11. Survival data and average DNA methylation/gene expression values of the TCGA-COAD patients included in the analyses related to the adenoma to carcinoma hypothesis.
es, lk, us
(code pays fourni par la source)