Linda Gelgor

CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus

Jade Ghosn, Tatiana Bayan, Karolin Meixenberger, Laurent Tran et autres

Background: The natural clinical and immunological courses following HIV seroconversion with CXCR4-tropic or dual-mixed (X4/DM) viruses are controversial. We compared spontaneous immunological outcome in patients harbouring an X4/DM virus at the time of seroconversion with those harbouring a CCR5-tropic (R5) virus. Methods: …

fr, de, it, at, es, gb (code pays fourni par la source)

A Phylogenetic Analysis of Human Immunodeficiency Virus Type 1 Sequences in Kiev: Findings Among Key Populations

Esther Fearnhill, Annabelle J. Gourlay, Ruslan Malyuta, Ruth Simmons et autres

Background: The human immunodeficiency virus (HIV) epidemic in Ukraine has been driven by a rapid rise among people who inject drugs, but recent studies have shown an increase through sexual transmission. Methods: Protease and reverse transcriptase sequences from 876 new HIV diagnoses …

gb, ua (code pays fourni par la source)

Role of prostaglandins in nociception during ischaemia and reperfusion of the rat's tail

Linda Gelgor

I have investigated the effects o f both systemic and intracerebroventricular \nadministration o f non-steroidal anti-inflammatory drugs (NSAIDs), o f varying \ntherapeutic potency, on i) nociception during tail ischaemia and ii) hyperalgesia to a \nnoxious thermal stimulus, evident during reperfusion of the …

The micro RNA ‐9/ B ‐lymphocyte‐induced maturation protein‐1/ IL ‐2 axis is differentially regulated in progressive HIV infection

Nabila Seddiki, Chansavath Phetsouphanh, Sanjay Swaminathan, Yin Xu et autres

The fine control of T-cell differentiation and its impact on HIV disease states is poorly understood. In this study, we demonstrate that B-lymphocyte-induced maturation protein-1 (Blimp-1/Prdm1) is highly expressed in CD4(+) T cells from chronically HIV-infected (CHI) patients compared to cells from …

au (code pays fourni par la source)

Differential Regulation of the Let-7 Family of MicroRNAs in CD4+ T Cells Alters IL-10 Expression

Sanjay Swaminathan, Kazuo Suzuki, Nabila Seddiki, Warren H. Kaplan et autres

MicroRNAs (miRNAs) are ∼22-nt small RNAs that are important regulators of mRNA turnover and translation. Recent studies have shown the importance of the miRNA pathway in HIV-1 infection, particularly in maintaining latency. Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells …

au, gb (code pays fourni par la source)

Impact of treatment with raltegravir during primary or chronic HIV infection on RNA decay characteristics and the HIV viral reservoir

Kersten K. Koelsch, Christoph Boesecke, Kristin L. McBride, Linda Gelgor et autres

BACKGROUND: Eradication of HIV-1 is prevented by the formation of viral reservoirs in peripheral blood, lymphoid tissues and other sanctuary sites. In most patients, rebound upon treatment cessation is prompt. We assessed whether early treatment with raltegravir can impact on the formation …

au, de, us, in (code pays fourni par la source)

Activation of NK Cells by ADCC Responses During Early HIV Infection

Amy W. Chung, Marjon Navis, Gamze Isitman, Robert James Finlayson et autres

Partial control of HIV occurs during acute infection, although the mechanisms responsible are poorly understood. We studied the ability of antibody-dependent cellular cytotoxicity (ADCC) antibodies in serum to activate natural killer (NK) cells in longitudinal samples from 8 subjects with well-defined early …

au (code pays fourni par la source)

HIV Immune Escape at an Immunodominant Epitope in HLA-B*27–Positive Individuals Predicts Viral Load Outcome

Palanee Ammaranond, David J. van Bockel, Kathy Petoumenos, Marylin McMurchie et autres

The CTL response in HLA-B*27(+) HIV-infected individuals is characterized by an immunodominant response to a conserved epitope in gag p24 (aa 263-272, KRWIILGLNK; KK10). Mutations resulting in substitution of the arginine (R264) at position 2 of this epitope have been identified as …

th, us, au (code pays fourni par la source)

Antihypernociceptive synergy between ibuprofen, paracetamol and codeine in rats

Duncan Mitchell, Linda Gelgor, Juliane Weber, Peter R. Kamerman

Afrique du Sud (code pays fourni par la source)

A Review of Raltegravir and its Use in HIV-1 Infection

Christoph Boesecke, Linda Gelgor

Raltegravir is the first antiretroviral drug in the class of integrase inhibitors approved for the treatment of human immunodeficiency virus type 1 (HIV-1) in combination with other antiretroviral agents in treatment-experienced adults with evidence of ongoing viral replication and resistance to multiple …

au (code pays fourni par la source)

Trends in antiretroviral treatment use and treatment response in three Australian states in the first decade of combination antiretroviral treatment

Kathleen Falster, Linda Gelgor, Ansari Shaik, Iryna Zablotska et autres

OBJECTIVES: To determine if there were any differences in antiretroviral treatment (ART) use across the three eastern states of Australia, New South Wales (NSW), Victoria and Queensland, during the period 1997 to 2006. METHODS: We used data from a clinic-based cohort, the …

au (code pays fourni par la source)

Epidemiology of primary HIV-1 infection

Linda Gelgor, John Martin Kaldor

PURPOSE OF REVIEW: To review recent studies reporting epidemiological and public health aspects of primary and recently acquired HIV infection, with a particular emphasis on patterns of occurrence, relationship to onward transmission, diagnostic strategies and risk factors. RECENT FINDINGS: Diagnosis of primary …

au (code pays fourni par la source)