Trends in antiretroviral treatment use and treatment response in three Australian states in the first decade of combination antiretroviral treatment
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Le résumé fourni par la source
OBJECTIVES: To determine if there were any differences in antiretroviral treatment (ART) use across the three eastern states of Australia, New South Wales (NSW), Victoria and Queensland, during the period 1997 to 2006. METHODS: We used data from a clinic-based cohort, the Australian HIV Observational Database (AHOD), to determine the proportion of HIV-infected patients on ART in selected clinics in each state and the proportion of treated patients with an undetectable viral load. Data from the national Highly Specialised Drugs program and AHOD were used to estimate total numbers of individuals on ART and the proportion of individuals living with HIV on ART nationally and by state. Data from the HIV Futures Survey and the Gay Community Periodic Survey were used to determine the proportion of community-based men who have sex with men on ART. The proportion of patients with primary HIV infection (PHI) who commenced ART within 1 year of diagnosis was obtained from the Acute Infection and Early Disease Research Program (AIEDRP) CORE01 protocol and Primary HIV and Early Disease Research: Australian Cohort (PHAEDRA) cohorts. RESULTS: We estimated that the numbers of individuals on ART increased from 3181 to 4553 in NSW, 1309 to 1926 in Victoria and 809 to 1615 in Queensland between 2000 and 2006. However, these numbers may reflect a lower proportion of individuals living with HIV on ART in NSW compared with the other states (37% compared with 49 and 55% in 2000). We found similar proportions of HIV-positive men who have sex with men participants were on ART in all three states over the study period in the clinic-based AHOD cohort (81-92%) and two large, community-based surveys in Australia (69-85% and 49-83%). Similar proportions of treated patients had an undetectable viral load across the three states, with a consistently increasing trend over time observed in all states. We found that more PHI patients commenced treatment in the first year following HIV diagnosis in NSW compared with Victoria; however, the sample size was very small. CONCLUSIONS: For the most part, patterns of ART use were similar across NSW, Victoria and Queensland using a range of available data from cohort studies, community surveys and national prescription databases in Australia. However, there may be a lower proportion of individuals living with HIV on ART in NSW compared with the other states, and there is some indication of a more aggressive treatment approach with PHI patients in NSW compared with Victoria.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Trends in antiretroviral treatment use and treatment response in three Australian states in the first decade of combination antiretroviral treatment
- Date Crossref
- 02/06/2008
- Éditeur
- CSIRO Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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New South Wales Department of Health pays non établi dans la noticeOrganisme public
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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National Centre for Clinical Research on Emerging Drugs pays non établi dans la noticeStructure de recherche
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La Trobe University DAustralian Research Centre in Sex pays non établi dans la noticeUniversité ou école supérieure
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Gold Coast Hospital pays non établi dans la noticeÉtablissement de santé
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Gold Coast Health pays non établi dans la noticeÉtablissement de santé
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The University of Sydney pays non établi dans la noticeUniversité ou école supérieure
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University of New South Wales ANational Centre in HIV Epidemiology and Clinical Research pays non établi dans la noticeUniversité ou école supérieure
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BSchool of Public Health and Community Medicine pays non établi dans la noticeUniversité ou école supérieure
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HCorresponding author. Email: kfalster@nchecr.unsw.edu.au pays non établi dans la noticeInstitution
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ECarlton Clinic pays non établi dans la noticeÉtablissement de santé
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FGold Coast Sexual Health Clinic pays non établi dans la noticeÉtablissement de santé
New South Wales Department of Health, UNSW Sydney et National Centre for Clinical Research on Emerging Drugs, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.