Roméo Ricci

Synovial lining macrophages form during early postnatal life via fetal-derived CX3CR1+ cells and AQP1+ intermediates

Marlène S. Magalhaes, Bert Malengier‐Devlies, Guillaume Seuzaret, Anna Ahlbäck et autres

The synovial lining maintains joint integrity, produces lubricating fluid, and forms a sterile barrier disrupted in inflammatory joint disease. It consists of specialized fibroblasts and macrophages, but its developmental timing and mechanisms are not well understood. We used genetic mouse models, imaging, …

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Author Reply to Peer Reviews of The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

Marlene Magalhaes Pinto, Bert Malengier‐Devlies, Guillaume Seuzaret, Anna Ahlback et autres

gb, be, de, cz, dk, fr, us, mx (code pays fourni par la source)

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

Marlene Magalhaes Pinto, Bert Malengier‐Devlies, Guillaume Seuzaret, Anna Ahlback et autres

Summary Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, lining macrophages regulate both early inflammatory cell influx and resolution. Despite these critical functions, it is currently unknown at what stage …

gb, fr, sg, de, dk, ca, mx, us (code pays fourni par la source)

KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation

Li Ran, Tao Ye, Eric Erbs, Stephan R. Ehl et autres

Immune cells sense the microenvironment to fine-tune their inflammatory responses. Patients with cryopyrin-associated periodic syndrome (CAPS), caused by mutations in the NLRP3 gene, develop autoinflammation triggered by nonantigenic cues such as from the environment. However, the underlying mechanisms are poorly understood. Here, …

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CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake

Kevin Vivot, Gergő Mészáros, Evanthia Pangou, Zhirong Zhang et autres

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KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation

Ran Li, Tao Ye, Eric Erbs, Stephan R. Ehl et autres

Abstract Immune cells sense the microenvironment to fine-tune their inflammatory responses. Patients with cryopyrin associated periodic syndrome (CAPS), caused by mutations in the NLRP3 gene, develop auto-inflammation triggered by non-antigenic, e.g. environmental cues. However, the underlying mechanisms are poorly understood. Here, we …

fr, de (code pays fourni par la source)

Distinct changes in endosomal composition promote NLRP3 inflammasome activation

Zhirong Zhang, Rossella Venditti, Ran Li, Zengzhen Liu et autres

Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad variety of cellular stressors. However, a primary and converging sensing mechanism by the NLRP3 receptor initiating …

fr, it, de, us (code pays fourni par la source)

CaMK1D signaling in AgRP neurons promotes ghrelin-mediated food intake

Kevin Vivot, Gergő Mészáros, Zhirong Zhang, Eric Erbs et autres

fr, de, es (code pays fourni par la source)

Genome-Scale CRISPR-Cas9 Knockout Screening of genes involved in pluripotency of Rabbit induced Pluripotent Stem Cells.

Hong Thu Pham, Zhirong Zhang, Nathalie Beaujean, Sylvie Rival-Gervier et autres

National audience

Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells

Federico Costanzo, Marta Martínez, Gema Santamaría Núñez, Juan Ignacio Díaz‐Hernandéz et autres

Small-Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy with a poor prognosis. Here, we focus on the neuroendocrine SCLC subtypes, SCLC-A and SCLC-N, whose transcription addiction was driven by ASCL1 and NEUROD1 transcription factors which target E-box motifs to activate up …

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NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Tingting Niu, Charlotte de Rosny, Séverine Chautard, Amaury Rey et autres

NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC and caspase-1 filaments, but the apical molecular mechanisms underlying inflammasome assembly remain elusive. Here …

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Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation

Roméo Ricci, Zhirong Zhang, Ran Li, Rossella Venditti et autres

fr, us, de, it (code pays fourni par la source)