Jie Liu

Incident chronic kidney disease risk and the predictive value of the uric acid-to-HDL ratio in lean and non-lean MASLD: a prospective cohort and multi-omics study

Yuting Zhang, Shurong Liu, Zijian Huang, Shuting Song et autres

cn, de, kg (code pays fourni par la source)

Endothelial Shear-Stress-Responsive Gene Adenylate Cyclase 4 Suppresses Atherosclerosis by Inhibiting cAMP/PKA-NF-κB Mediated Vascular Inflammation

Wenzhen Bao, Jianfei Xu, Wenjian Nian, Peilin Pang et autres

BACKGROUND: Endothelial dysfunction is critical for the pathogenesis of atherosclerosis, particularly in arterial regions exposed to disturbed flow (DF). ADCY4 (adenylate cyclase 4) catalyzes the production of cAMP (cyclic adenosine monophosphate), a ubiquitous second messenger that regulates cellular and physiological processes. This …

cn (code pays fourni par la source)

Fibroblast S1PR2 Amplifies NLRP3 Inflammasome Activation Under Pressure Overload

Caixia Zhou, Zhihao Liu, Zhiru Wang, Zekun Cui et autres

BACKGROUND: Although NLRP3 (NOD-like receptor family pyrin domain containing 3) inflammasome activation has been implicated in pressure overload-induced cardiac hypertrophy, inflammation, and heart failure, prior studies have focused primarily on cardiomyocytes and immune cells. The potential contribution of cardiac fibroblasts to NLRP3 …

cn (code pays fourni par la source)

Global variation in patient factors, interventions, and postoperative outcomes for those undergoing trauma laparotomy: an international, prospective, observational cohort study

Michael Bath, Joachim K. A. Amoako, Katharina Köhler, Zhongheng Zhang et autres

BACKGROUND: The trauma laparotomy is a definitive intervention for life-threatening abdominal injuries and a cornerstone of trauma care globally. The ability to perform an emergency laparotomy is a recognised marker of safe and effective surgical care within a health system. However, the …

gb, Ghana, cn, République démocratique du Congo, co, mx, it, in, us, Afrique du Sud (code pays fourni par la source)

Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure

Wenrun Wu, Xiaoli Chen, Jianfei Xu, Jinnan Yue et autres

BACKGROUND AND AIMS: Endothelial cells (ECs) sense flow shear stress for vasodilation, a crucial mechanism for maintaining systemic blood pressure (BP). Impaired shear stress signalling contributes to endothelial dysfunction and hypertension. Heart development protein with EGF-like domain 1 (HEG1), a flow-sensitive, endothelial-derived …

cn, de (code pays fourni par la source)

SLC1A5-dependent glutamine uptake in hepatocytes promotes liver regeneration

Yunhao Duan, Sheng Peng, Jinnan Yue, Xiaoli Chen et autres

BACKGROUND: The liver's remarkable regenerative capacity after injury restores essential functions for maintaining homeostasis. Understanding molecular circuits initiating liver regeneration leads to new therapies. Solute carrier family 1, member 5 (SLC1A5) is a key glutamine transporter crucial for hepatocyte proliferation. This study …

cn, de, es, us (code pays fourni par la source)

Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway

Yanfang Wang, Xiaoyu Wang, Fang Ji, Xiaoli Chen et autres

The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regulates embryonic cardiomyocyte proliferation and heart development. However, whether Foxp1 participates in postnatal-injury cardiomyocyte proliferation and heart regeneration remains unclear. This study …

cn, mo, tw, us (code pays fourni par la source)

Toward exploring noncontinuous-state dynamics based on pulse-modulated frequency-shifted laser feedback interferometry

Jie Li, Jie Liu, J. Liu, Hongtao Li et autres

An exhaustive study of the noncontinuous-state laser dynamics associated with the transient optical process is significant because it reveals the complex physical mechanisms and characteristics in nonlinear laser systems. In this study, in-depth theoretical interpretation and experimental verification of the noncontinuous-state dynamics …

cn (code pays fourni par la source)

CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway

Qi Zhang, Tao Zhuang, Lehua Xu, Wenrun Wu et autres

BACKGROUND AND AIMS: Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects of CCN5 on neointimal formation and its role in preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). …

cn, us (code pays fourni par la source)

Modelling myocardial ischemia/reperfusion injury with inflammatory response in human ventricular cardiac organoids

Laihai Zhang, Yun Yao Jiang, Wenwen Jia, Wenjun Le et autres

Current therapeutic drug exploring targeting at myocardial ischemia/reperfusion (I/R) injury is limited due to the lack of humanized cardiac models that resemble myocardial damage and inflammatory response. Herein, we develop ventricular cardiac organoids from human induced pluripotent stem cells (hiPSCs) and simulate …

cn (code pays fourni par la source)

Tumor-associated characteristics and immune dysregulation in nasopharyngeal carcinoma under the regulation of m7G-related tumor microenvironment cells

Zhen Long, Xiaochen Li, Wenmin Deng, Yan Tan et autres

Abstract Background Nasopharyngeal carcinoma (NPC) is a type of malignant tumor with high morbidity. Aberrant levels of N7-methylguanosine (m7G) are closely associated with tumor progression. However, the characteristics of the tumor microenvironment (TME) in NPC associated with m7G modification remain unclear. Methods …

cn (code pays fourni par la source)

Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo, Juan Du, Yang Yang, Mingxing Wu et autres

Abstract Real-world data on effectiveness and safety of a single non-vitamin K antagonist oral anticoagulant in the Chinese population with atrial fibrillation (AF) are limited. This study reports characteristics of patients treated with edoxaban and factors associated with dosing patterns from routine …

cn, us (code pays fourni par la source)