Yang Yang

Altered relative GLP-1 response patterns in gestational diabetes mellitus: a matched nested case-control study

Yingmiao Wu, Ping Luo, Keying Qin, Zicong Lin et autres

Circulating glucagon-like peptide−1 (GLP-1) findings in gestational diabetes mellitus (GDM) are inconsistent, and plasma GLP-1 concentrations do not directly measure incretin function. We characterized total GLP-1 profiles during the measured time points of an oral glucose tolerance test (OGTT) and explored their …

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Acute cerebral infarction with ipsilateral hemiparesis and tractography findings consistent with asymmetric corticospinal tract non-decussation: a case report

Lu Wang, Dongliang Hao, Zhuoran Qu, Ruiqi Song et autres

Most corticospinal tract (CST) fibres decussate at the medullary pyramids, such that supratentorial infarction typically causes contralateral weakness. Markedly asymmetric or absent CST decussation is uncommon and may create unexpected lesion-deficit laterality. We report a patient with an acute left hemispheric infarct …

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Chemokines in cardiovascular and cerebrovascular pathogenesis: Emerging therapeutic targets

Jiaxing Wang, Yunfeng Ni, Hui Chang, Mingzhen Zhang et autres

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Characterization of Antioxidant Constituents and Geographical Differentiation of Polygonum multiflorum Thunb. Leaves Using 2D-LC-ECD and UHPLC-Orbitrap-MS/MS

Zhengyan Tan, Pei Xu, Dan Wang, Zongna Han et autres

This study established an activity-oriented analysis method based on offline two-dimensional liquid chromatography–electrochemical detection (2D-LC-ECD) combined with ultra-high-performance liquid chromatography–Orbitrap-MS/MS (UHPLC-Orbitrap-MS/MS), which was used to comprehensively characterize the antioxidant components of Polygonum multiflorum Thunb. leaves (PML) and screen for differential compounds in …

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Food preservative intake and cancer risk: A commentary on evidence from a large prospective cohort study

Xingyu Zhu, Yunfeng Ni, Mingya Zhang, Huiping Li et autres

Food preservatives are ubiquitous components of ultra-processed food (UPF), 1 yet their longterm health effects remain insufficiently characterized.The recent NutriNet-Santé prospective cohort study by Hasenböhler et al. 2 provides new evidence on the association between food additive preservative intake and cancer incidence.Importantly, …

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Pregnancy loss and prevalent cardiometabolic multimorbidity: a two-stage individual participant data analysis of CHARLS, ELSA, and HRS

Yang Yang, Kunying Rao, Feng Pan, Chunmei Ren

Cardiovascular disease remains the leading cause of death worldwide, and cardiometabolic multimorbidity (CMM) is associated with substantially higher mortality and reduced life expectancy. Pregnancy loss is common and has been linked to later cardiovascular risk, but multinational evidence using harmonized individual participant …

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Methodological considerations on a meta-analysis of TEAS for post-anesthetic shivering

Mengjin Yu, Xiaoyan Liu, Lei Li, Yang Yang

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YOLO-SCC: A Lightweight Object Detection Method for Mine Safety

Zhe Wu, Xuanrui Zhang, Yanping Cui, Yang Yang et autres

To address the challenges in personnel detection in underground coal mines, such as uneven lighting, dust occlusion, cluttered backgrounds, and significant scale variation of targets, this paper proposes a lightweight object detection method named YOLO-SCC. Based on the lightweight detection network YOLO26n, …

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Multiomics Profiling Identifies Blood‐Based Diagnostic Markers for Sepsis

Xin Zhang, Xiaoqing Guo, Shuai Jiang, Yanting Cao et autres

Sepsis, characterized by a rapid transition to systemic immune dysregulation and multiorgan failure, poses a formidable clinical challenge. The lack of spatiotemporally stable biomarkers severely impedes early diagnosis and risk stratification. By integrating large-scale transcriptomic profiling with machine learning algorithms, this study …

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Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

X L Yang, Ya Wang, Yanjiao Yi, Yang Yang et autres

Breast cancer represents the most common malignant tumor in women globally. Isoleucyl-tRNA synthetase 2 (IARS2), a member of the aminoacyl-tRNA synthetase family, promotes tumorigenesis across various cancers. Herein, the effects and mechanisms of IARS2 in breast cancer were investigated. IARS2 is upregulated …

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The protective role of SIRT1 in cardiovascular disease: from molecular mechanisms to potential therapeutic strategies

Haixin Ma, Shuya Wang, ZIJIAN DANG, Wentao Xie et autres

Introduction Cardiovascular diseases (CVDs) pose a significant threat to the health of middle-aged and elderly people. They are widely recognized as a major public health concern. The sirtuin (SIRT) family comprises seven proteins (SIRT1–SIRT7), all of which contain a highly conserved nicotinamide …

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Wearable device-measured moderate to vigorous physical activity and aortic valve stenosis: revisiting the preventability of degenerative aortic valve stenosis

Mingya Zhang, Huadong Zhao, Yanqing Liu, Huiping Li et autres

This study highlights the role of moderate-to-vigorous physical activity (MVPA) in preventing degenerative aortic valve stenosis (AS). Using 7-day wrist-worn accelerometer data from the UK Biobank, researchers found that higher MVPA was associated with a lower risk of developing AS. Similar associations …

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