Accès ouvert
2026
preprint
OpenAlex
Naoki Hirono, Masanori Uchikawa, Arisa Tanigawa, Takeru Fujii et autres
SUMMARY During embryonic development, cellular competence to respond to differentiation signals changes dynamically. Although the mechanisms underlying competence acquisition have been extensively studied, those underlying competence loss remain unclear. In preimplantation mouse embryos, Hippo signaling shifts from regulating trophectoderm (TE) fate specification …
gb, jp
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Jun‐Ya Kaimori, Yamato Kikkawa, Daisuke Motooka, Tomoko Namba‐Hamano et autres
The LAMA5 gene encodes laminin α5, an indispensable component of glomerular basement membrane and other types of basement membrane. A homozygous pathological variant in LAMA5 is known to cause a systemic developmental syndrome including glomerulopathy. However, the roles of heterozygous LAMA5 gene …
jp, cn, us
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Accès ouvert
2020
article
OpenAlex
Kazuto Yoshimi, Yuichiro Oka, Yoshiki Miyasaka, Yuko Kotani et autres
CRISPR-Cas9 are widely used for gene targeting in mice and rats. The non-homologous end-joining (NHEJ) repair pathway, which is dominant in zygotes, efficiently induces insertion or deletion (indel) mutations as gene knockouts at targeted sites, whereas gene knock-ins (KIs) via homology-directed repair …
jp
(code pays fourni par la source)