Hakan Zengil

Cytochrome P450 2J2*7 Single-nucleotide Polymorphism and Nocturnal Hypertension in an Elderly Turkish Population

Elif Hilal Vural, Arzu Güneş Granberg, Atiye Çengel, Marja-Liisa Dahl et autres

Objective: Blood pressure shows a physiological diurnal rhythm. Altered blood pressure circadian rhythm is more common in the elderly. Nocturnal hypertension (NH) and/or impaired nocturnal dipping profile are associated with increased mortality risk. The CYP2J2*7 polymorphism is associated with decreased arachidonic acid …

Flavin-Containing Monooxygenase 3 Polymorphisms in 13 Ethnic Populations from Europe, East Asia and Sub-Saharan Africa: Frequency and Linkage Analysis

Mao Mao, Alice Matimba, Maria Gabriella Scordo, Arzu Gunes et autres

AIMS: To investigate intra- and inter-ethnic differences in three widespread (E158K, V257M and E308G) and two African-specific (D132H and L360P) flavin-containing monooxygenase 3 (FMO3) polymorphisms. MATERIALS & METHODS: Allele frequencies were determined by TaqMan allelic discrimination assay in 2152 healthy volunteers from …

se, Afrique du Sud, Zimbabwe, it, tr, jp (code pays fourni par la source)

Influence of Genetic Polymorphisms, Smoking, Gender And Age on Cyp1A2 Activity in a Turkish Population

Arzu Gunes, Gül Özbey, Elif Hilal Vural, Canan Uluoğlu et autres

AIMS: To study the variation in CYP1A2 activity in relation to smoking, gender, age and CYP1A2 polymorphisms. MATERIALS & METHODS: CYP1A2 activity was determined by plasma paraxanthine:caffeine ratio (17X:137X) 4 h after the intake of a standardized cup of coffee in 146 …

se, tr (code pays fourni par la source)

The circadian rhythm of morphine-induced analgesia abolishes after chronic lithium treatment in old mice

Elif Hilal Vural, Hakan Zengil

The effect of chronic lithium treatment on morphine-induced analgesia was studied in a time-dependent manner in old mice. All mice received lithium chloride via drinking water of 600 mg/l for three weeks. Both basal pain sensitivity and morphine-induced analgesia were determined with …

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Possible Involvement of Eicosanoids in Alpha-Naphthylthiourea-lnduced Pulmonary Oedema and Alteration of Angiotensin-Converting Enzyme Activity

Sevim Z. Ercan, Sami Eren, Hakan Zengil, Kazim T uuml rker

alpha-Naphthylthiourea (ANTU) when injected intraperitoneally to rats at a dose of 10 mg/kg elicited lung oedema indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion. The injection of acetylsalicylic acid, which is a cyclo-oxygenase inhibitor, and BW 755C, …

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Temperature-Dependent Specific Desensitization in the Rat Anococcygeus Muscle to Angiotensin II

Hakan Zengil, Nurettin Abaao gbreve lu, Idot lker Kanz inodot k

The effect of angiotensin II (A II) on isolated rat anococcygeus muscle was investigated. A II, when used submaximally (4 X 10(-9) mol/l), produced a rapid contraction of the rat anococcygeus muscle. However, a profound tachyphylaxis developed with repeated administrations. This tachyphylaxis …

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The effect of experimental diabetes on the circadian pattern of adenosine deaminase and myeloperoxidase activities in rat liver.

Canan Uluoğlu, B. Cimen, Gül Özbey, Çi̇men Karasu et autres

This study investigated time-dependent variations in the activities of adenosine deaminase (ADA), an adenosine-metabolizing enzyme, and myeloperoxidase (MPO), an oxidation reaction-catalyzing enzyme, in control and streptozotocin (STZ)-induced diabetic rat liver. The animals were sacrificed at six different times of day (1, 5, …

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Day and night effect of single dose of ionising radiation and melatonin treatment of lung tissue of rats

Yıldız Güney, Canan Uluoğlu, Ayşe Hiçsönmez, Ümmühani Özel Türkçü et autres

953 POSTER The effect of melatonin on radiation-induced hepatic damage in rats

Akgün Hiçsönmez, Yıldız Güney, Canan Uluoğlu, Zafer Güney et autres

Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine

Yıldız Güney, Akgün Hiçsönmez, Canan Uluoğlu, H. Zafer Güney et autres

We investigated the day-night differences in intestinal oxidative-injury and the inflammatory response following total body (TB) or abdominopelvic (AP) irradiation, and the influence of melatonin administration on tissue injury induced by radiation. Rats (male Wistar, weighing 220-280 g) in the irradiated groups …

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Inhibitory Effect of Valproic Acid on Cytochrome P450 2C9 Activity in Epilepsy Patients

Arzu Gunes, Erhan Bilir, Hakan Zengil, Melih Onder Babaoglu et autres

Drug interactions constitute a major problem in the treatment of epilepsy because drug combinations are so common. Valproic acid is a widely used anticonvulsant drug with a broad therapeutic spectrum. Case reports suggest interaction between valproic acid and other drugs metabolized mainly …

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Lack of a time‐dependent effect of melatonin on radiation‐induced apoptosis in cultured rat lymphocytes

Erkan Yurtçu, Yıldız Güney, Mehmet Ali Ergün, H. Zafer Güney et autres

Ionizing radiation is widely used for the treatment of solid tumors and it is thought to act by directly targeting tumor clonogens, also known as stem cells. Apoptosis is a genetically programmed mechanism of cell death often characterized by internucleosomal DNA cleavage. …

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