Çi̇men Karasu

Effects of hypochlorous acid, povidone-iodine, and Carrel-Dakin solution irrigation on open fracture healing: a rat femur model

Hüseyin Emre Tepedelenlioğlu, Gökçe Nur Arik Erol, Kemal Şibar, Çiğdem Elmas et autres

Open fractures require immediate irrigation and debridement to minimize the risk of contamination and support subsequent wound management. However, antiseptic irrigants may also exert local cytotoxic or osteogenesis-impairing effects. The objective of this study was to conduct a comparative analysis of the …

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REJENERA©, a multi-component bioflavonoid-based formula, alleviates osteoarthritis and provides chondroprotection by regulating the NLRP3-TXNIP-iNOS axis and inflammation: a comparative study with olive leaf nutraceuticals and ibuprofen

Hüseyin Emre Tepedelenlioğlu, Zübeyir Elmazoğlu, Sanem Sarıbaş, Yıldız Tütüncü et autres

Abstract Osteoarthritis (OA) primarly involves the degradation of joint cartilage and requires new treatments. REJENERA © , a newly developed nutraceutical formula against OA, contains primarily olive leaf bioflavonoids ( ZeyEX © , quercetin and luteolin), S -allylcysteine, palmitoylethanolamide, l -proline, hyaluronic …

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Taliglucerase Alfa Reduces Amyloid-β Burden by Restoring Autophagic Pathways in a Neuronal Model of Alzheimer’s Disease

Çağrı Özkurt, Selma Köse, Çi̇men Karasu, Arjan Kortholt et autres

Abstract Intraneuronal amyloid-beta (Aβ) accumulation and autophagic dysfunction are key pathological features of Alzheimer’s disease (AD). Mutations in GBA1 , which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are linked to several neurodegenerative disorders, but the role of GCase in AD remains incompletely …

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Single Intra‐Articular Anakinra (IL‐1Ra) Versus Betamethasone in Rabbit Post‐Traumatic Knee Osteoarthritis: IL‐8 Suppression and Chondrocyte Viability

Hüseyin Emre Tepedelenlioğlu, Duygu Dayanir, Zübeyir Elmazoğlu, Candan Özoğul et autres

Post-traumatic osteoarthritis (OA) is driven by a sustained inflammatory response and progressive osteochondral damage. We compared the effects of a single intra-articular injection of anakinra (Interleukin-1 receptor antagonist; IL-1Ra) with those of betamethasone on structural cartilage outcomes and Interleukin-8 (IL-8) immunopositivity in …

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A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats

Fatma Kaya Dağıstanlı, Asli Fahriye Ceylan, Zübeyir Elmazoğlu, Nigar Efendiyeva et autres

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Taliglucerase Alfa Modulates Aβ Load and Autophagy-Related Pathways in Mouse Hippocampal Neurons Exposed to oAβ1-42

Çağrı Özkurt, Selma Köse, Çi̇men Karasu, Arjan Kortholt et autres

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S-allyl-cysteine triggers cytotoxic events in rat glioblastoma RG2 and C6 cells and improves the effect of temozolomide through the regulation of oxidative responses

Carolina Y. Reyes-Soto, Ricardo Jair Ramírez Carreto, Luz Belinda Ortiz-Alegría, Alejandro Silva‐Palacios et autres

Glioblastoma (GBM) is an aggressive form of cancer affecting the Central Nervous System (CNS) of thousands of people every year. Redox alterations have been shown to play a key role in the development and progression of these tumors as Reactive Oxygen Species …

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Protection against α-Amanitin-induced liver toxicity: Efficacy of pomegranate seed oil and black cumin oil

Fatih Sezer, Zübeyir Elmazoğlu, Güldal Esendağlı, Sevil Özger İlhan et autres

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A Dual Acting Aldose Reductase Inhibitor Induces Tissue Defense Against Oxidative andInflammatory Stress in Rat Models for Metabolic Disorders

Çi̇men Karasu, ASLI FAHRİYE CEYLAN, Tala Reihanifar, Abel Santamaría et autres

A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine

Alican Kaya, Asli Fahriye Ceylan, Mustafa Kavutçu, Abel Santamarı́a et autres

Inhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at least delay the progression of diabetes mellitus (DM). This study was aimed at evaluating …

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Corrigendum to “Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons” [Neurochemistry International 140 (2020) 104817]

Zübeyir Elmazoğlu, Edgar Rangel‐López, Omar Noel Medina‐Campos, José Pedraza‐Chaverrí et autres

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Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors

Karen Jaqueline Paredes-Ruiz, Karla Chavira-Ramos, Sonia Galván‐Arzate, Edgar Rangel‐López et autres

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