H. Zafer Güney

Investigation of Drug-Drug Interactions in Oncology Patients

Demet Döndü Kasım, Fatih Gürler, Bediz Kurt İnci, Ahmet Özet et autres

Giriş: Ek hastalığa sahip kanser hastaları onkolojik tedavilerinin yanında, diğer hastalıklara özgü farklı farmakolojik gruplarda düzenli ilaç kullanmaktadır.Bu durum morbidite ve mortalite artışına yol açan potansiyel ilaç-ilaç etkileşimlerine (PİİE) yol açmaktadır.Çalışmada amaç onkoloji hastalarında görülen PİİE'yi göstermektir.Yöntem: Medikal Onkoloji kliniğinde kanser tanılı, …

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Defining the awareness and attitude of the clinicians through pharmacovigilance in Turkey

Özlem Çelik Aydın, Sonay Aydın, H. Zafer Güney

BACKGROUND: Pharmacovigilance (PV) is the activities and scientific studies conducted to detect, evaluate, understand or prevent adverse reactions and other drug-related problems. AIM: To define the awareness and experiences of the clinicians on PV and adverse drug reactions (ADRs) in Turkey. METHODS: …

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The Evaluation of the Prevalence of Improper Medication Use in Patients Age of 65 and over in Internal Diseases and Neurology Intensive Care Units in Terms of Stopp-Start Criteria

A Erdil, H. Zafer Güney

The Evaluation of the Prevalence of Improper Medication Use in Patients Age of 65 and over in Internal Diseases and Neurology Intensive Care Units in Terms of Stopp-Start Criteria - Gazi Medical Journal

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The Development, Indications, and the Safety of Monoclonal Antibodies

H. Zafer Güney

Monoclonal antibodies (mAbs) are described as brand-new tools used in the therapy of cancer, autoimmune and infectious diseases, transplant rejection, and some other new indications.MAbs have been shown to create some adverse events such as hypersensitivity reactions, immunological problems, cardiovascular diseases, respiratory …

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Pharmacovigilance and radiologists: How well do they get along?

Özlem Çelik Aydın, Sonay Aydın, H. Zafer Güney

OBJECTIVES: Considering the growing use of imaging modalities and contrast agents, radiologists are prone to encounter adverse drug reactions (ADR). In the current study, we mainly aim to evaluate the knowledge of radiologists regarding pharmacovigilance (PV). Also, we intend to gather information …

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Kontrast Ajanlar; Farmakolojik Özellikleri, Genel Advers Reaksiyonları ve İlaç Etkileşimleri

Özlem Çelik Aydın, Sonay Aydın, H. Zafer Güney

Kontrast ajanlar, genel radyoloji pratiğinde sıklıkla kullanılmaktadırlar. Kontrast ajanları temel olarak iyotlu kontrast ajanları ve gadolinyum bazlı kontrast ajanları olarak ayrılırlar. Bu derlemede amaç, genel kontrast ajanlarının temel farmakolojik özelliklerini, uygulama sonrasında görülen advers reaksiyonları ve ilaç etkileşimlerini özetlemektir. Contrast agents are …

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Comparison Of The Concentrations Of Cyclosporine-A Containing Ophthalmic Microemulsion And Nanosuspansion Formulations In Aqueous Humor In The Rabbit Experiment Model

Osman Karakus, Tuğhan DURAN, İsmail Tuncer Değim, Burcu Eser et autres

Background: Dry eye, which is a result of decrease in the production of tears or an increase in evaporation, is a disease that causes complaints of foreign body sensation and pain. Even if the pathophysiology of the disease is not fully understood, …

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Klinik Araştırmalar İçin Gönüllü Olmak

H. Zafer Güney

Prolonged Cold Storage Diminishes the 5-Hydroxytryptamine- and Potassium Chloride-Mediated Contractions of Rat Thoracic Aorta

H. Zafer Güney, Zeynep Sevim Ercan

Hypothermic preservation of the organ for transplantation causes vascular damage; therefore, the preservation of vascular function is important for the organs to function correctly after transplantation. The aim of the present study is to evaluate the influence of prolonged cold storage (72 …

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Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine

Yıldız Güney, Akgün Hiçsönmez, Canan Uluoğlu, H. Zafer Güney et autres

We investigated the day-night differences in intestinal oxidative-injury and the inflammatory response following total body (TB) or abdominopelvic (AP) irradiation, and the influence of melatonin administration on tissue injury induced by radiation. Rats (male Wistar, weighing 220-280 g) in the irradiated groups …

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Lack of a time‐dependent effect of melatonin on radiation‐induced apoptosis in cultured rat lymphocytes

Erkan Yurtçu, Yıldız Güney, Mehmet Ali Ergün, H. Zafer Güney et autres

Ionizing radiation is widely used for the treatment of solid tumors and it is thought to act by directly targeting tumor clonogens, also known as stem cells. Apoptosis is a genetically programmed mechanism of cell death often characterized by internucleosomal DNA cleavage. …

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Carnosine may reduce lung injury caused by radiation therapy

Yıldız Güney, Ümmühani Özel Türkçü, Ayşe Hiçsönmez, Meltem Nalça Andrıeu et autres

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