Accès ouvert
2025
preprint
OpenAlex
Hiroyuki Matsui, Marlene Cervantes, Mir Mubashir Khalid, Alan Tomusiak et autres
Aging impacts immune function, but the mechanisms driving age-related changes in immune cell subsets remain unclear. To explore age-dependent changes in immune cell populations, we analyzed human peripheral blood mononuclear cells (PBMCs) from a cohort of healthy donors aged 20-82 years using …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Erik Jacques, Chiara Maria Stella Herzog, Kejun Ying, Alan Tomusiak et autres
us, at, gb, se, de, cn, hr, sa, sg, nl, ca
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Alan Tomusiak, Sierra Lore, Morten Scheibye‐Knudsen, Eric M. Verdin
Abstract Biomarkers of aging provide insight into the biological effects of interventions and diseases. However, most biomarkers today are based on measurements derived from bulk cell measurements, making it challenging to interpret whether an effect is due to changes in cell type …
us, dk
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah R. Riley et autres
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are connected to aging-associated pathologies, and changes in epigenetic …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Edwin Ho Ming Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner et autres
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Edwin Ho Ming Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner et autres
Abstract Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Eric M. Verdin, Alan Tomusiak, Ariel Floro, Ritesh Tiwari et autres
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah R. Riley et autres
Abstract Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are connected to aging-associated pathologies, and changes in …
us
(code pays fourni par la source)