Rinku Sharma

The impact of vitamins A and D on lung function and regulatory epigenetics in adult and childhood asthma

Rinku Sharma, Priyadarshini Kachroo, Kevin M. Mendez, Q Chen et autres

Objective Vitamins A and D regulate numerous genes through intersecting metabolic pathways, influencing lung development and asthma. This article aimed to examine the impact of vitamins A and D on lung function, epigenetic ageing and regulatory epigenetics in children and adults with …

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Large-scale antibody reactome profiling identifies herpesvirus-autoantigen associations underlying chronic diseases

Sanghun Lee, Nicole Prince, Qingwen Jia Xiaohan Chen, Xueying Chen et autres

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Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity

Rinku Sharma, R Kelly, Kevin M. Mendez, Qingwen Jia Xiaohan Chen et autres

RATIONALE: We previously validated five clinically distinct asthma metabo-endotypes (mechanistically derived asthma subgroups). We hypothesize that metabo-endotype membership may be partially driven by differences in serum microRNA profiles and their influence on metabolite levels. OBJECTIVES: To determine whether serum miRNA levels can …

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A Categorical ANCOVA Approach to Severity Endophenotype-Specific Genome-Wide Association Studies in Childhood Asthma

Shraddha Piparia, Parham Hadikhani, John P. Ziniti, Julian Hecker et autres

Objective: Asthma is a complex and heterogeneous syndrome, making it hard to predict disease progression and suitable treatments. One strategy for reducing this uncertainty is to define genetic subtypes, or endophenotypes, that capture shared biological mechanisms. Most genome-wide studies, however, compare one …

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A principal component analysis-based endophenotype definition for change in lung function and inhaled corticosteroid treatment response in childhood asthma

Shraddha Piparia, Alvin T. Kho, Brinda Desai, Richard J. Wong et autres

Asthma is a clinically and biologically heterogeneous syndrome with variable symptom patterns, severity, and treatment responses. Understanding this heterogeneity is important for developing personalized management strategies. In this study, we applied principal component analysis to multiple comparable baseline clinical features in three …

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Micro-RNA prediction tools and target analysis

Anshul Tiwari, Rinku Sharma

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A Principal Component Analysis-Based Endophenotype Definition for Change in Lung Function and Inhaled Corticosteroid Treatment Response in Childhood Asthma

Shraddha Piparia, Alvin T. Kho, Richard L Wong, Rinku Sharma et autres

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Serum microRNA expression quantitative trait loci in children with asthma colocalize with asthma-related GWAS results

Julian Hecker, Anshul Tiwari, Rinku Sharma, Kevin M. Mendez et autres

Asthma poses a significant public health burden. Despite identifying more than a hundred genetic risk loci in genome-wide association studies (GWAS), the underlying functional mechanisms remain poorly understood. Studying omics, especially microRNAs (miRNAs), is a promising approach to facilitate our understanding of …

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Circulating miRNAs and childhood asthma ICS response: a stratified analysis in the intervention arm of an RCT with vitamin D effect modification

Mingye Jiang, Yunxiao Zhang, Tao Liu, Xiaoning Hong et autres

Background miRNAs play a crucial role in the anti-inflammatory effects of inhaled corticosteroids (ICS) in asthma. Vitamin D can modulate the expression of several miRNAs and reduces asthma exacerbations, but its molecular interaction with ICS remains unclear. Objective We hypothesised that vitamin …

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MicroRNA-584-5p As a Key Modulator of Inhaled Corticosteroid Resistance in Asthma

Shraddha Piparia, Alvin T. Kho, P. Hadikhani, Ga‐Young Ban et autres

Abstract Background: MicroRNAs are increasingly recognized as important biomarkers of treatment response in asthma. Although inhaled corticosteroids (ICS) are widely used to treat asthma exacerbations, their effectiveness varies significantly among patients, posing challenges in optimizing treatment outcomes. Objective: In this study, we …

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Asthma Exacerbations: Integrative Analysis of Mirna Activity in Using Single-cell Transcriptomics

P. Hadikhani, Xiting Yan, Geoffrey Lowell Chupp, Qing Liu et autres

Abstract Background Asthma exacerbations are caused by dysregulated cellular interactions between airway and immune cell populations. Circulating microRNAs (miRNAs) are potential biomarkers for asthma exacerbations; however, their target airway cells remain poorly defined. Objective To identify the cell types that are regulated …

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Exploring the Varied Clinical Presentation of Pediatric Asthma through the Metabolome

Kevin M. Mendez, Priyadarshini Kachroo, Nicole Prince, Mengna Huang et autres

Abstract Rationale Pediatric asthma is heterogeneous, with varied clinical presentations and treatment responses. Metabolomic profiling may uncover shared and unique biological mechanisms across clinical traits that characterize pediatric asthma. Objectives To characterize the varied clinical presentation of pediatric asthma by examining the …

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