Jianghong Zhang

CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1

Liang Zeng, Yuchuan Zhou, Linbo Cai, Wang Zheng et autres

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, for which radiotherapy constitutes the key component of standard comprehensive treatment; however, tumor relapse could inevitably arise from intrinsically radioresistant GBM subclones. Radiotherapy exerts biphasic regulatory effects on the tumor immune microenvironment …

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Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells

Yuqi Xiao, Mingyuan He, Han Yao, Yimeng Song et autres

Cellular dormancy in colorectal cancer (CRC) significantly contributes to therapeutic resistance, tumor recurrence, and metastasis, resulting in poor prognosis. However, the underlying molecular mechanisms remain poorly understood. Here, we used spheroid culture combined with serum deprivation to enrich and identify dormancy-like CRC …

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Digital navigation-assisted resection of cemento-ossifying fibroma in the right mandible: A case report and literature review

LIU Yuping, Tai Wang, Jianghong Zhang

Cemento-ossifying fibroma (COF) is a rare benign odontogenic tumor of mesenchymal origin, predominantly occurring in the tooth-bearing areas of the mandible. This article reports a case of COF located in the right mandible, focusing on its clinical manifestations and digital navigation-assisted surgical …

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Unilateral Fractionated Thoracic Irradiation Induces Abscopal Injury in Contralateral Lung through NF-κB Pathway

Xinglong Liu, Yimeng Song, Songling Hu, Yang Bai et autres

Radiotherapy may cause acute and late damage to off-target abscopal tissues, and the underlying signaling factors need further exploration. This study aimed to investigate whether local irradiation could induce damage in non-irradiated abscopal lung tissues using a murine model subjected to fractionated …

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Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance

Jialing Zhang, Xiaoya Jin, Maidina Abulaihaiti, Xinglong Liu et autres

Hypoxia-induced radioresistance presents a major barrier to effective radiotherapy of non-small cell lung cancer (NSCLC), while the underlying role of macrophages remaining elusive. In this study, we found that, compared with normoxia-derived tumor exosomes, hypoxia-derived tumor exosomes more potently promoted M2 polarization …

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TMEM164 enhances radioresistance of GBM cells by inhibiting the FASN-NADPH-ROS axis

Zhaoyan Jiang, Xiaoya Jin, Jialing Zhang, Liang Zeng et autres

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[Study on transmission characteristics and genetic variation of carbapenem-resistant Klebsiella pneumonia based on whole genome sequencing].

J. C. Li, Yulu Chen, Y L Ge, J R Hu et autres

The popular strain in the hospital of CRKP is a KPC-2_ST11 clone group carrying iucA, rmpA/rmpA2, with cross-department transmission and mutation. ST5492 is a newly-launched clone type. The intensive care unit of hvKP carrying five virulence genes, including peg-344, should be alert …

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Weak Galerkin Finite Element Method Based on POD for Nonlinear Parabolic Equations

Jianghong Zhang, Jintao Cui

In this paper, we establish a novel reduced-order weak Galerkin (ROWG) finite element method for solving parabolic equation with nonlinear compression coefficient. We first present the classical weak Galerkin finite element discretization scheme and derive the optimal error estimates. Then we apply …

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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation

Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao et autres

BACKGROUND: Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. However, the underlying mechanisms of its pathogenesis are still inconclusive. No approved biomarker or medicine is available …

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Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma

Yuchuan Zhou, Liang Zeng, Linbo Cai, Zheng Wang et autres

Glioblastoma multiforme (GBM) remains a therapeutic challenge due to its aggressive nature and recurrence. This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these cells. Comprehensive genomic and transcriptomic analyses identify IFI16 as …

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Investigation into the stability of monometallic metal oxide electrocatalysts for hydrogen peroxide synthesis through the oxygen reduction reaction

D. Chen, Yue Zhang, Yuebin Feng, Jianghong Zhang et autres

Catalyst stability crucially impacts the practical value of the catalyst in industrial applications. This comprehensive review aims to lay the foundation for the rational design of high-performance transition metal oxide (TMO) catalysts.

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Cytological changes in radiation-induced lung injury

Yun Wang, Jianghong Zhang, Chunlin Shao

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