Francesco Foppiano

Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE

Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Laubhahn et autres

Abstract Background The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity …

nl, de, ch, us, gr (code pays fourni par la source)

Additional file 1 of Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE

Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Laubhahn et autres

Supplementary Material 1: Additional material including supplementary methods, legends of supplementary figures and supplementary tables.

de (code pays fourni par la source)

Additional file 1 of Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE

Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Laubhahn et autres

Supplementary Material 1: Additional material including supplementary methods, legends of supplementary figures and supplementary tables.

de (code pays fourni par la source)

Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE.

Lena Lagally, Lena Ullemeyer, Jimmy Omony, Kristina Gottschau et autres

Background The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity levels.Methods …

at, us (code pays fourni par la source)

Meta-analysis of genome-wide association studies of food allergy and IgE sensitization

the Estonian Biobank Research Team, Lisa Maier, Yidan Sun, Jaanika Kronberg et autres

Background: Food allergy (FA) arises from a complex interplay between an individual’s genetic predisposition and environmental factors, and its prevalence is increasing. Genome-wide association studies to date have been hindered by small sample sizes and varying FA definitions. Objective: We sought to …

Early neutrophil and persistent eosinophil-associated gene signature in childhood asthma.

Francesco Foppiano, Andreas Böck, Claudia Beerweiler, Kathrin Urner et autres

Rationale Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear.Objectives To identify differences in longitudinal whole-blood gene expression during early childhood in future asthmatics compared to healthy children.Methods We conducted …

at, us (code pays fourni par la source)

Early neutrophil and persistent eosinophil-associated gene signature in childhood asthma

Francesco Foppiano, A. Böck, Claudia Beerweiler, Kathrin Urner et autres

RATIONALE: Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear. OBJECTIVES: To identify differences in longitudinal whole-blood gene expression during early childhood in future asthmatics compared to healthy children. METHODS: …

nl, de, ch, fi, fr (code pays fourni par la source)

Meta-analysis of genome-wide association studies of food allergy and IgE sensitization

Lisa Maier, Yidan Sun, Jaanika Kronberg, Erik Abner et autres

BACKGROUND: Food allergy (FA) arises from a complex interplay between an individual's genetic predisposition and environmental factors, and its prevalence is increasing. Genome-wide association studies to date have been hindered by small sample sizes and varying FA definitions. OBJECTIVE: We sought to …

nl, de, ee, gb, fi, se, au, fr, dk, es, at (code pays fourni par la source)

Impaired skin barrier and allergic sensitization in 16-year-old adolescents

Sonali Pechlivanis, Elisabeth Schmaußer‐Hechfellner, Bianca Schaub, Chrysanthi L. Skevaki et autres

Abstract Background Transepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic diseases in infancy. However, few studies have assessed the association between TEWL and allergic diseases in adolescents. Objective To …

de, fr, ch, fi, us (code pays fourni par la source)

Childhood asthma phenotypes and endotypes: a glance into the mosaic

Francesco Foppiano, Bianca Schaub

BACKGROUND: Asthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma shows large heterogeneity regarding onset of disease, symptoms, severity, prognosis, and response to therapy. MAIN BODY: Evidence suggests that this variability is due …

de (code pays fourni par la source)

TIGER: technical variation elimination for metabolomics data using ensemble learning architecture

Siyu Han, Jialing Huang, Francesco Foppiano, Cornelia Prehn et autres

Large metabolomics datasets inevitably contain unwanted technical variations which can obscure meaningful biological signals and affect how this information is applied to personalized healthcare. Many methods have been developed to handle unwanted variations. However, the underlying assumptions of many existing methods only …

de, us, si, sg, qa, cn, it (code pays fourni par la source)