Claudia Beerweiler

Early neutrophil and persistent eosinophil-associated gene signature in childhood asthma.

Francesco Foppiano, Andreas Böck, Claudia Beerweiler, Kathrin Urner et autres

Rationale Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear.Objectives To identify differences in longitudinal whole-blood gene expression during early childhood in future asthmatics compared to healthy children.Methods We conducted …

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Early neutrophil and persistent eosinophil-associated gene signature in childhood asthma

Francesco Foppiano, Andreas Böck, Claudia Beerweiler, Kathrin Urner et autres

RATIONALE: Early childhood represents a critical window for asthma susceptibility, marked by developmental and molecular changes, yet their longitudinal pattern remains unclear. OBJECTIVES: To identify differences in longitudinal whole-blood gene expression during early childhood in future asthmatics compared to healthy children. METHODS: …

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Farm‐dust mediated protection of childhood asthma: Mass cytometry reveals novel cellular regulation

Claudia Beerweiler, Michael Salvermoser, Johanna Theodorou, Andreas Böck et autres

Abstract Background Farm‐dust mediated asthma protection in childhood was replicated in numerous epidemiological studies. Central immune mechanisms are not fully understood. This exploratory study aimed to disentangle underlying immunological regulation of farm‐dust mediated protection in peripheral blood on a single‐cell level. Methods …

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Impaired skin barrier and allergic sensitization in 16-year-old adolescents

Sonali Pechlivanis, Elisabeth Schmaußer‐Hechfellner, Bianca Schaub, Chrysanthi L. Skevaki et autres

Abstract Background Transepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic diseases in infancy. However, few studies have assessed the association between TEWL and allergic diseases in adolescents. Objective To …

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Asthma and allergic diseases: Cross talk of immune system and environmental factors

Claudia Beerweiler, Rebecca Katharina Masanetz, Bianca Schaub

Air pollution and immune-related diseases including allergy and asthma are constantly on the rise worldwide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for a deeper understanding of disease pathogenesis, progression as well as prevention. Here, we summarize the …

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Author response for "Asthma and allergic diseases: Cross talk of Immune System and Environmental Factors"

Claudia Beerweiler, Rebecca Katharina Masanetz, Bianca Schaub

Mitogen‐activated protein kinase signaling in childhood asthma development and environment‐mediated protection

Johanna Theodorou, Elisabeth Nowak, Andreas Böck, Michael Salvermoser et autres

BACKGROUND: While childhood asthma prevalence is rising in Westernized countries, farm children are protected. The mitogen-activated protein kinase (MAPK) pathway with its negative regulator dual-specificity phosphatase-1 (DUSP1) is presumably associated with asthma development. OBJECTIVES: We aimed to investigate the role of MAPK …

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Author response for "Mitogen‐activated protein kinase signaling in childhood asthma development and environment‐mediated protection"

Johanna Theodorou, Elisabeth Nowak, Andreas Böck, Michael Salvermoser et autres