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2026
preprint
OpenAlex
Lea Separovic, Samantha E Kaweski, Michelle B. Cox, Yuping Zhan et autres
Abstract Background The 2025/26 influenza season included A(H3N2) subclade K predominance with A(H1N1)pdm09 co-circulation and subsequent prolonged influenza B activity. The Canadian Sentinel Practitioner Surveillance Network reports vaccine effectiveness (VE) in the context of genetic and antigenic relatedness to circulating viruses. Methods …
ca
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2026
article
OpenAlex
Danuta M. Skowronski, Yuping Zhan, Samantha E Kaweski, Michelle B. Cox et autres
BACKGROUNDThe Canadian Sentinel Practitioner Surveillance Network routinely undertakes multiplex respiratory virus testing, vaccine effectiveness (VE) estimation by test-negative design (TND), and whole genome sequencing (WGS) of vaccine-targeted viruses.AIMTo estimate 2025/26 LP.8.1 VE against community-based COVID-19, including variant-specific, and explore the impact of …
ca
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2026
article
OpenAlex
Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres
The Canadian Sentinel Practitioner Surveillance Network used the test-negative design to assess KP.2 vaccine effectiveness (VE) against medically attended outpatient COVID-19 between November 2024 and April 2025 among participants ≥ 12 years. Analyses included 5410 controls (19% vaccinated) and 435 COVID-19 cases …
ca
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2026
article
OpenAlex
Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres
In interim 2025/26 analyses, the Canadian Sentinel Practitioner Surveillance Network estimates influenza vaccine reduced the risk of medically-attended acute respiratory illness due to predominant influenza A(H3N2) viruses, including antigenically distinct subclade K, by about 40% relative to unvaccinated individuals. Vaccine effectiveness was …
ca
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2025
article
OpenAlex
Sarah E. Wilson, Vanessa Zubach, Brendan Lew, Maan Hasso et autres
We report a case of a mild, self-limited rash illness in a child 18 days after measles-mumps-rubella-varicella vaccination. Initial testing with a PCR-based method failed to detect vaccine virus. Sequencing later identified a novel mutation in the probe-binding site of the vaccine …
ca
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2025
preprint
OpenAlex
Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres
Abstract Between November 2024 and April 2025, the Canadian Sentinel Practitioner Surveillance Network assessed KP.2 vaccine effectiveness against outpatient COVID-19 by test-negative design. Vaccination protected best during the first two months, reducing risk by two-thirds among vaccinated versus unvaccinated individuals, declining by …
ca, Côte d’Ivoire
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2025
article
OpenAlex
Lea Separovic, Yuping Zhan, Samantha E Kaweski, Suzana Sabaiduc et autres
The Canadian Sentinel Practitioner Surveillance Network (SPSN) reports interim 2024/25 vaccine effectiveness (VE) against acute respiratory illness due to laboratory-confirmed influenza during a delayed season of predominant A(H1N1)pdm09 and lower A(H3N2) co-circulation. Through mid-January, the risk of outpatient illness due to influenza …
ca
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2024
article
OpenAlex
Danuta M. Skowronski, Yuping Zhan, Samantha E Kaweski, Suzana Sabaiduc et autres
The Canadian Sentinel Practitioner Surveillance Network reports mid-season 2023/24 influenza vaccine effectiveness (VE) of 63% (95% CI: 51-72) against influenza A(H1N1)pdm09, lower for clade 5a.2a.1 (56%; 95% CI: 33-71) than clade 5a.2a (67%; 95% CI: 48-80), and lowest against influenza A(H3N2) (40%; …
ca
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2023
article
OpenAlex
Danuta M. Skowronski, Erica S.Y. Chuang, Suzana Sabaiduc, Samantha E Kaweski et autres
The Canadian Sentinel Practitioner Surveillance Network estimated vaccine effectiveness (VE) during the unusually early 2022/23 influenza A(H3N2) epidemic. Like vaccine, circulating viruses were clade 3C.2a1b.2a.2, but with genetic diversity affecting haemagglutinin positions 135 and 156, and reassortment such that H156 viruses acquired …
ca
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2022
article
OpenAlex
Maan Hasso, Stephen J. Perusini, Alireza Eshaghi, Elaine Tang et autres
A global monkeypox outbreak began in May 2022. Limited data exist on specimen type performance in associated molecular diagnostics. Consequently, a diverse range of specimen sources were collected in the initial weeks of the outbreak in Ontario, Canada. Our clinical evaluation identified …
ca, gb
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2022
article
OpenAlex
Shin Hye Kim, Erica S.Y. Chuang, Suzana Sabaiduc, Romy Olsha et autres
Influenza virus circulation virtually ceased in Canada during the COVID-19 pandemic, re-emerging with the relaxation of restrictions in spring 2022. Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network reports 2021/22 vaccine effectiveness of 36% (95% CI: -38 to 71) against …
ca
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2022
article
OpenAlex
Mariana Abdulnoor, Alireza Eshaghi, Stephen J. Perusini, George Broukhanski et autres
During the coronavirus disease 2019 (COVID-19) pandemic, several variants of concern (VOCs) have been detected, for example, B.1.1.7, B.1.351, P.1, and B.1.617.2. The VOCs pose a threat to public health efforts to control the spread of the virus. As such, surveillance and …
ca
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