Maan Hasso

2025/26 subclade-specific influenza A and B vaccine effectiveness estimates and discordant laboratory-based indicators of vaccine match or mismatch

Lea Separovic, Samantha E Kaweski, Michelle B. Cox, Yuping Zhan et autres

Abstract Background The 2025/26 influenza season included A(H3N2) subclade K predominance with A(H1N1)pdm09 co-circulation and subsequent prolonged influenza B activity. The Canadian Sentinel Practitioner Surveillance Network reports vaccine effectiveness (VE) in the context of genetic and antigenic relatedness to circulating viruses. Methods …

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Monkeypox-Associated Disciform Keratitis: Retraction

Waleed K. Alsarhani, Clara C. Chan, Shelley R. Boyd, Maan Hasso et autres

Interim 2025/26 LP.8.1 vaccine effectiveness estimates against COVID-19 from the Canadian Sentinel Practitioner Surveillance Network (SPSN): insights into possible impact of influenza and other respiratory virus co-circulation

Danuta M. Skowronski, Yuping Zhan, Samantha E Kaweski, Michelle B. Cox et autres

BACKGROUNDThe Canadian Sentinel Practitioner Surveillance Network routinely undertakes multiplex respiratory virus testing, vaccine effectiveness (VE) estimation by test-negative design (TND), and whole genome sequencing (WGS) of vaccine-targeted viruses.AIMTo estimate 2025/26 LP.8.1 VE against community-based COVID-19, including variant-specific, and explore the impact of …

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Effectiveness of 2024/25 KP.2 Vaccine Against Outpatient COVID‐19 in Canada

Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres

The Canadian Sentinel Practitioner Surveillance Network used the test-negative design to assess KP.2 vaccine effectiveness (VE) against medically attended outpatient COVID-19 between November 2024 and April 2025 among participants ≥ 12 years. Analyses included 5410 controls (19% vaccinated) and 435 COVID-19 cases …

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Genomic, antigenic and transmission dynamics of influenza A(H3N2) subclade K in Canada, early 2025/26 season

George S. Long, Thomas Braukmann, Nicholas Waglechner, Patryk Aftanas et autres

Abstract Influenza A(H3N2) subclade K virus was detected in Canada early in the 2025/26 influenza season, bearing an antigenic transition in the hemagglutinin (HA) glycoprotein. Analysis of 396 HA sequences from Canada showed antigenic divergence from 2025/26 influenza vaccine strains, consistent with …

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Interim 2025/26 influenza vaccine effectiveness estimates with immuno-epidemiological considerations for A(H3N2) subclade K protection, Canada, January 2026

Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres

In interim 2025/26 analyses, the Canadian Sentinel Practitioner Surveillance Network estimates influenza vaccine reduced the risk of medically-attended acute respiratory illness due to predominant influenza A(H3N2) viruses, including antigenically distinct subclade K, by about 40% relative to unvaccinated individuals. Vaccine effectiveness was …

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Detection of non-travel-associated, ceftriaxone non-susceptible Neisseria gonorrhoeae FC428-like harbouring the mosaic penA60 allele in Ontario, Canada

Adam S. Komorowski, Alireza Eshaghi, Jennifer Burbidge, Karen O. Johnson et autres

Background: This case report describes a young male with multidrug-resistant Neisseria gonorrhoeae infection acquired in Ontario, Canada with no travel history.Methods: Case follow-up was conducted following routine public health practice in Ontario.Antimicrobial susceptibility testing of the isolate was done by agar dilution.Strain …

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Détection de Neisseria gonorrhoeae FC428 ayant l’allèle mosaïque penA60, non associé à des voyages et non sensible à la ceftriaxone en Ontario, Canada

Adam S. Komorowski, Alireza Eshaghi, Jennifer Burbidge, Karen S. Johnson et autres

Contexte : Ce rapport décrit le cas d'un jeune homme atteint d'une infection à Neisseria gonorrhoeae multirésistante contractée en Ontario, au Canada, sans aucun antécédent de voyage.Méthodes : Le suivi de cas a été effectué conformément aux pratiques courantes de santé publique …

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Measles vaccine virus mutation following vaccination in a healthy child resulting in a false negative vaccine specific PCR test: Ontario, Canada, 2025

Sarah E. Wilson, Vanessa Zubach, Brendan Lew, Maan Hasso et autres

We report a case of a mild, self-limited rash illness in a child 18 days after measles-mumps-rubella-varicella vaccination. Initial testing with a PCR-based method failed to detect vaccine virus. Sequencing later identified a novel mutation in the probe-binding site of the vaccine …

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Effectiveness of 2024/25 KP.2 vaccine against outpatient COVID-19 in Canada

Lea Separovic, Suzana Sabaiduc, Yuping Zhan, Samantha E Kaweski et autres

Abstract Between November 2024 and April 2025, the Canadian Sentinel Practitioner Surveillance Network assessed KP.2 vaccine effectiveness against outpatient COVID-19 by test-negative design. Vaccination protected best during the first two months, reducing risk by two-thirds among vaccinated versus unvaccinated individuals, declining by …

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Strategies for Success in Endoscopic Retrograde Cholangiopancreatography (ERCP) Intervention in Liver Transplant Patients with Biliary Complications and Altered Intestinal Anatomy

Muhammad Salman Faisal, Abdulaziz Saleem, Bradley Karmo, Maan Hasso et autres

Purpose: Surgically altered anatomy in patients who undergo Liver Transplant (LT) offers a unique challenge to endoscopists. There is limited data regarding the optimal endoscopic approach for the management of biliary complications in this population. We aim to assess the safety, efficacy …

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Global Circulation of RSV-A ON1 Genotype Strains without Characteristic 72-Nucleotide Duplication in the G Gene, 2010-2023

Kuganya Nirmalarajah, Thomas Braukmann, Shawn T. Clark, Alex Marchand‐Austin et autres

Background: Human respiratory syncytial virus (RSV) is a primary etiological agent responsible for lower respiratory tract infections in children and older adults. The ON1 genotype replaced all previous strains of RSV-A and is characterized by a 72 base pair duplication in the …

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