Nadine Reichhart

Anoctamin‐1 Is a Calcium‐Dependent Chloride Channel ( CaCC ) in Müller Cells Involved in Cell Volume Regulation

Alissa Schaefer, Oliver Bludau, Andjela Sekulic, Sena Altunok et autres

ABSTRACT Previous functional data showed the presence of Cl − channels in Müller cells, among them Ca 2+ ‐dependent Cl − channels (CaCC). An important step to understanding the role of CaCC in Müller cell function is the clarification of their molecular …

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Radiation Retinopathy: Microangiopathy-Inflammation-Neurodegeneration

Anja‐Maria Davids, Inga-Marie Pompös, Norbert Kociok, Jens Heufelder et autres

Purpose: Proton irradiation is used to treat choroidal melanoma of the eye. The impact on non-malignant retinal cells is currently understudied. Therefore, we here report a mouse model to investigate the impact of proton irradiation on the retina. Methods: We performed a …

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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration

Lucas Stürzbecher, Hendrik Bartolomaeus, Theda Ulrike Patricia Bartolomaeus, Sylvia Bolz et autres

Introduction Age-related macular degeneration (AMD) is a leading cause of blindness with limited treatment options. Dysfunction of the retinal pigment epithelium (RPE) is a unifying salient feature of the pathology and a primary end-point damage leading to complications such as geographic atrophy …

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Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect

Fang Yang, Anaïs Begemann, Nadine Reichhart, Akvile Haeckel et autres

Anoctamins are a family of Ca 2+ -activated proteins that may act as ion channels and/or phospholipid scramblases with limited understanding of function and disease association. Here, we identified five de novo and two inherited missense variants in ANO4 (alias TMEM16D ) …

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Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration

Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning et autres

Abstract Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-derived cells, which promote photoreceptor degeneration and choroidal neovascularization. Infiltrating blood …

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Ionenkanäle des retinalen Pigmentepithels

Nadine Reichhart, Olaf Strauß

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Additional file 1 of Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration

Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning et autres

Additional file 1: Table S1. Fold Changes (FC) of the 70 genes upregulated between SplMo and BMMo in scRNAseq experiment. The frequency of Ly6C+Mos in the spleen, in sham Eye and SpleX eye represents the percentage of cells with an expression level …

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FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration

Ahmad Samir Alfaar, Lucas Stürzbecher, Maria Diedrichs‐Möhring, Marion Lam et autres

BACKGROUND: Forkhead-Box-Protein P3 (FoxP3) is a transcription factor and marker of regulatory T cells, converting naive T cells into Tregs that can downregulate the effector function of other T cells. We previously detected the expression of FoxP3 in retinal pigment epithelial (RPE) …

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Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy

Sergio Crespo‐Garcia, Nadine Reichhart, Norbert Kociok, Sergej Skosyrski et autres

Diabetic retinopathy is characterized by dysfunction of the retinal vascular network, combined with a persistent low-grade inflammation that leads to vision-threatening complications. Netrin-4 (NTN4) is a laminin-related secreted protein and guidance cue molecule present in the vascular basal membrane and highly expressed …

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Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse

Anna-Karina B. Maier, Nadine Reichhart, Johannes Gonnermann, Norbert Kociok et autres

Tumor necrosis factor (TNF)α is an inflammatory cytokine likely to be involved in the process of corneal inflammation and neovascularization. In the present study we evaluate the role of the two receptors, TNF-receptor (TNF-R)p55 and TNF-Rp75, in the mouse model of suture-induced …

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Prediction of Functional Consequences of Missense Mutations in ANO4 Gene

Nadine Reichhart, Vladimir M. Milenkovic, Christian H. Wetzel, Olaf Strauß

-dependent scramblases. ANO4 which is primarily expressed in the CNS and certain endocrine glands, has been associated with various neuronal disorders. Therefore, we focused our study on prioritizing missense mutations that are assumed to alter the structure and stability of ANO4 protein. …

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Data Set to: Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse

Anna-Karina B. Maier, Nadine Reichhart, Norbert Kociok

Data Set to: Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse Raw data and image files