Zonglin Chen

Clinical trajectories after preoperative traditional Chinese medicine in biologic-refractory surgery- intended acute severe ulcerative colitis: an exploratory retrospective case series

Pengfei Tian, Zonglin Chen, Xin Yu, Biaojie Fang et autres

Objective Acute severe ulcerative colitis (ASUC) is a life-threatening condition, and biologic-refractory patients may ultimately require surgery. The clinical role of individualised integrative management including traditional Chinese medicine (TCM) in surgery-intended ASUC remains uncertain. Methods This single-centre retrospective exploratory case series included …

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Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer

Shilong Jiang, Junyan Liu, Hui Li, Chan Zou et autres

Identifying novel therapeutic targets and drugs is crucial for treating triple-negative breast cancer (TNBC). Bufalin, a key active ingredient of the traditional Chinese medicine HuaChansu, has been employed in tumor therapy. Here, SPR-LC-MS/MS is employed to characterize the targets of Bufalin and …

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Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha

Shilong Jiang, Keyi Liu, Ting Jiang, Hui Li et autres

Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of action remains unclear. Here, we employ artificial intelligence, molecular …

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Investigating the relationship between tongue diagnosis features and gastric cancer: A machine learning-based prediction model

Pengfei Tian, Zonglin Chen, Xintian Wang, Xin Feng Yu et autres

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Applying a multi-task and multi-instance framework to predict axillary lymph node metastases in breast cancer

Yi‐Zhi Li, Zonglin Chen, Ziyuan Ding, Dan Mei et autres

Deep learning (DL) models have shown promise in predicting axillary lymph node (ALN) status. However, most existing DL models were classification-only models and did not consider the practical application scenarios of multi-view joint prediction. Here, we propose a Multi-Task Learning (MTL) and …

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GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62

Xiaoya Wan, Shilong Jiang, Yidi Guan, Yi‐Zhi Li et autres

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Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1

Linhao He, Jiaying He, Ting Jiang, Xiaoya Wan et autres

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Identification of a Novel Substrate for eEF2K and the AURKA‐SOX8 as the Related Pathway in TNBC

Xiaoya Wan, Xiaobao Zhao, Yizhi Li, Tianlong Shan et autres

Eukaryotic elongation factor 2 kinase (eEF2K) has been considered as a putative target for cancer therapy; however, the underlying mechanisms of eEF2K in triple-negative breast cancer (TNBC) progression remain to be fully elucidated. In this study, it is shown that eEF2K is …

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Retraction notice to "HDAC3 increases HMGB3 expression to facilitate the immune escape of breast cancer cells via down-regulating microRNA-130a-3p" [Int. J. Biochem. Cell Biol. 135 (2021) 105967]

Zonglin Chen, Lei Pei, Danhua Zhang, Feng Xu et autres

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Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple‐Negative Breast Cancer

Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian et autres

Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple-negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti-cancer activity have not been available so far. Targeted protein degradation has emerged …

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Targeting lncRNA DDIT4‐AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy

Ting Jiang, Jiaojiao Zhu, Shilong Jiang, Zonglin Chen et autres

In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4-AS1), is highly expressed in triple-negative breast cancer (TNBC) cell lines and tissues due to H3K27 acetylation in the promoter region, and promotes the proliferation, migration, …

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Supplementary Figures 1-11 from A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Marcus Schmidt, Birte Hellwig, Seddik Hammad, Amnah Othman et autres

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