Colin Jamora

Evaluation of Melanocytes and T-cells in Vitiliginous Skin Pre- and Post-Narrow-Band UVB Phototherapy

A. K. Dutta, Dyuti Saha, T S Nagesh, Shanaya Phal Desai et autres

BACKGROUND: Vitiligo is an autoimmune disorder characterized by the destruction of epidermal melanocytes, leading to white lesions devoid of pigmentation. The destruction of epidermal melanocytes is driven by tissue-resident and circulating immune cells that maintain an inflammatory milieu. Two percent of the …

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Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness

Binita Dam, Johan Ajnabi, Tirthankar Saha, Ashish Shrivastava et autres

BACKGROUND: Keratinocyte stem cells are essential for maintaining epidermal homeostasis and enabling efficient tissue repair. Regulation of their self-renewal and differentiation is critical, as its disruption can impair regeneration and drive pathological conditions such as chronic wounds and cancer. We previously identified …

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OC.20 One protein, many paths: mindin orchestrates subtype-specific profibrotic fibroblast responses in scleroderma

Gaurav Kansagara, Sunny Kataria, Isha Rana, Arnab Mukherjee et autres

Introduction Dysregulated fibroblast activation lies at the core of scleroderma pathogenesis, driving persistent inflammation, excessive collagen secretion, and progressive fibrosis in the skin and, at advanced stages, internal organs. Despite growing insights into the cellular complexity of the disease, the upstream molecular …

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Assessing the Wound Healing Efficacy of Wrightia tinctoria Protease-Hydrolysed Cobia Skin Collagen: An In Vivo and In Silico Study

Parimala Karthik, Bindhu Omana Sukumaran, Colin Jamora

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Spatial transcriptomic analysis of the immune landscape following NBUVB treatment of vitiligo skin

Abhik Dutta, Divya Gupta, Johan Ajnabi, Binita Dam et autres

Abstract Objectives Vitiligo is an autoimmune disorder characterised by the presence of depigmented lesions on the skin. The autoreactive cytotoxic T cells at the epidermal‐dermal junction of the skin facilitate the targeted destruction of epidermal melanocytes, leading to the development of vitiligo …

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Actin-dependent mechanotransduction controls nucleocytoplasmic partitioning of DNMT3a through ERK1/2 signaling during cutaneous wound healing

Johan Ajnabi, Binita Dam, Ekta Gupta, Tirthankar Saha et autres

Abstract Cutaneous wound healing is a multifaceted physiological process that requires a cell state transition from homeostasis to tissue repair. An important contributor to this reprogramming is the wound-induced mechanical cues that are perceived by epidermal keratinocytes. Previously we identified that the …

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305 The Matricellular Protein Mindin Regulates Differential Fibroblast Responses to Manifest Dermal Fibrosis in Scleroderma

Gaurav Kansagara, Sushma K. Kataria, Isha Rana, Colin Jamora

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Mindin mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness

Binita Dam, Johan Ajnabi, Tirthankar Saha, Krithika Badarinathan et autres

Abstract Signalling networks rely not only on specific protein interactions but also on the subcellular locales at which these occur. Such spatial control is fundamental to cellular behaviour in both physiological and pathological scenarios. In studying keratinocyte stemness, we previously identified a …

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12-Hydroxystearic acid induces epidermal keratinocytes to secrete antimicrobial peptides that are potent inhibitors of viral infection

Obed Manglalsiem Gangte, Tanay Bhatt, Ananya Grewall, Anupama Ashok et autres

ABSTRACT Epidermal keratinocytes produce antimicrobial peptides (AMPs) that serve as a crucial component of the skin’s innate immune barrier. These peptides effectively target a broad spectrum of pathogenic microorganisms while preserving commensal microbiota essential for skin barrier homeostasis and overall skin health. …

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Angiopoietin-like protein 2 mediates vasculopathy-driven fibrogenesis in a mouse model of systemic sclerosis

Dyuti Saha, Sujaya Thannimangalath, Sunny Kataria, Binita Dam et autres

Vasculopathy is a common hallmark of various fibrotic disorders, including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill defined. In SSc, the vasculopathy typically precedes the onset of fibrosis, and we observed that this phenomenon is recapitulated …

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Vaccination-based immunotherapy to target profibrotic cells in liver and lung

Michal Sobecki, Jing Chen, Ewelina Krzywińska, Shunmugam Nagarajan et autres

Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients

Akshay Hegde, Dyuti Saha, Savitha Somaiah, Colin Jamora

Background: Androgenic alopecia (AGA) is a pathological condition characterized by the progressive decrease of scalp hair follicle density. Completely bald areas of AGA scalp exhibit a drastically decreased number of progenitor cells. However, it is unknown when the progenitor cells begin to …

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