Johan Ajnabi

Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness

Binita Dam, Johan Ajnabi, Tirthankar Saha, Ashish Shrivastava et autres

BACKGROUND: Keratinocyte stem cells are essential for maintaining epidermal homeostasis and enabling efficient tissue repair. Regulation of their self-renewal and differentiation is critical, as its disruption can impair regeneration and drive pathological conditions such as chronic wounds and cancer. We previously identified …

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Spatial transcriptomic analysis of the immune landscape following NBUVB treatment of vitiligo skin

Abhik Dutta, Divya Gupta, Johan Ajnabi, Binita Dam et autres

Abstract Objectives Vitiligo is an autoimmune disorder characterised by the presence of depigmented lesions on the skin. The autoreactive cytotoxic T cells at the epidermal‐dermal junction of the skin facilitate the targeted destruction of epidermal melanocytes, leading to the development of vitiligo …

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Actin-dependent mechanotransduction controls nucleocytoplasmic partitioning of DNMT3a through ERK1/2 signaling during cutaneous wound healing

Johan Ajnabi, Binita Dam, Ekta Gupta, Tirthankar Saha et autres

Abstract Cutaneous wound healing is a multifaceted physiological process that requires a cell state transition from homeostasis to tissue repair. An important contributor to this reprogramming is the wound-induced mechanical cues that are perceived by epidermal keratinocytes. Previously we identified that the …

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Mindin mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness

Binita Dam, Johan Ajnabi, Tirthankar Saha, Krithika Badarinathan et autres

Abstract Signalling networks rely not only on specific protein interactions but also on the subcellular locales at which these occur. Such spatial control is fundamental to cellular behaviour in both physiological and pathological scenarios. In studying keratinocyte stemness, we previously identified a …

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Harmonizing plant resilience: unveiling the symphony of membrane lipid dynamics in response to abiotic stresses: a review

Suman Dutta, Zaherul Islam, Sumanta Das, Anamika Barman et autres

Abiotic stresses, such as drought, heat and cold stress, high salinity, and heavy metal toxicity, are detrimental to plants for growth and development, leading to significant economic loss due to crop yield penalties worldwide. All living organisms including plants are sensitive to …

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Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption

Tanay Bhatt, Binita Dam, Sneha Uday Khedkar, Sahil Lall et autres

The continual emergence of SARS-CoV-2 variants threatens to compromise the effectiveness of worldwide vaccination programs, and highlights the need for complementary strategies for a sustainable containment plan. An effective approach is to mobilize the body's own antimicrobial peptides (AMPs), to combat SARS-CoV-2 …

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Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis

Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam et autres

Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading to a poor prognosis. Unraveling the etiology of a chronic, multifactorial disease such as systemic sclerosis has been aided by various animal models that recapitulate …

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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin

Krithika Badarinath, Binita Dam, Sunny Kataria, Ravindra K. Zirmire et autres

Preservation of a small population of cancer stem cells (CSCs) within a heterogeneous carcinoma serves as a paradigm to understand how select cells in a tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but …

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Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis

Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam et autres

ABSTRACT Fibrosis is a result of chronically activated fibroblasts leading to the overproduction of extracellular matrix (ECM), causing tissue hardening and loss of organ function. Systemic sclerosis (SSc) is a fibrotic skin disease marked by inflammation, autoimmunity and vasculopathy along with progressive …

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Identification of cis-regulatory regions regulating the expression of PM19 gene in wheat

Johan Ajnabi