Valeriia Grudtsyna

Mechanical memory of confinement pressure governs expansion size in epithelial monolayers

Linn Engström, Simon K. Schnyder, Johannes Kumra Ahnlide, Valeriia Grudtsyna et autres

Abstract Epithelial tissues undergo rapid expansion during development, repair, and morphogenesis, yet how tissue-scale growth is coordinated to re-establish homeostasis remains unclear. Here, we show that large epithelial monolayers confined at a wide range of initial densities and mechanochemical states robustly converge …

se, jp, dk, nl (code pays fourni par la source)

Cell division sets a universal flow geometry in cell layers

Tianxiang Ma, Lasse Bonn, Valeriia Grudtsyna, Nigar Abbasova et autres

Collective flows in epithelial tissues contain a geometric backbone of vortical interfaces whose statistics exhibit hallmarks of critical percolation and conformal invariance. Yet how fundamental cellular processes govern the breakdown of such symmetry-rich flow geometry remains unclear. Here we show that cell …

dk, pt (code pays fourni par la source)

Epithelia Realize Nematopolar Topological Defect Structures

Tianxiang Ma, Niels de Graaf Sousa, Valeriia Grudtsyna, Farzan Vafa et autres

We introduce a shape-based polar order parameter that captures the structural asymmetry of cells within epithelial monolayers. By combining bright-field imaging and traction force microscopy, we demonstrate that shape polarity serves as a unifying biomechanical metric, integrating the physical information encoded by …

Epithelia Realize Nematopolar Topological Defect Structures

Ma Tc, Niels de Graaf Sousa, Valeriia Grudtsyna, Farzan Vafa et autres

We introduce a shape-based polar order parameter that captures the structural asymmetry of cells within epithelial monolayers. By combining bright-field imaging and traction force microscopy, we demonstrate that shape polarity serves as a unifying biomechanical metric, integrating the physical information encoded by …

dk (code pays fourni par la source)

A spectrum of p -atic symmetries and defects in confluent epithelia

Lea Happel, Griseldis Oberschelp, Anneli Richter, Gwenda Roselene Rode et autres

Topological defects provide a unifying language to describe how orientational order breaks down in active and living matter. They are identified for various p -atic orders.

de, dk (code pays fourni par la source)

Packing-driven mechanotransduction: local crowding overrides adhesion and stiffness cues for YAP activation in cellular collectives

Valeriia Grudtsyna, Vinay Swaminathan, Amin Doostmohammadi

The regulation of mechanotransduction is crucial for various cellular processes, including stem cell differentiation, wound healing and cancer progression. While the activation of mechanotransduction has been extensively studied in single cells, it remains unclear whether similar mechanisms extend to mechanotransduction in multicellular …

dk, se (code pays fourni par la source)

Author response: Quantifying the shape of cells, from Minkowski tensors to p-atic orders

Lea Happel, Griseldis Oberschelp, Valeriia Grudtsyna, Harish P Jain et autres

de, dk, no, gb (code pays fourni par la source)

Quantifying the shape of cells, from Minkowski tensors to p-atic orders

Lea Happel, Griseldis Oberschelp, Valeriia Grudtsyna, Harish P Jain et autres

P -atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is, therefore, essential for unraveling the physical mechanisms that govern tissue dynamics. Due to the deformability of cells …

cn, dk, no, gb, de (code pays fourni par la source)

Cellular Flow Architecture Exposes the Hidden Mechanics of Biological Matter

Tianxiang Ma, Valeriia Grudtsyna, Robin V. Bölsterli, Amin Doostmohammadi

Understanding how biomechanical reorganization governs key biological processes, such as morphogenesis and development, requires predictive insights into stress distributions and cellular behavior. While traditional approaches focused on cell motion as a response to stress, we demonstrate that Lagrangian coherent structures (LCSs)—robust attractors …

dk (code pays fourni par la source)

Packing-Driven Mechanotransduction: local crowding overrides adhesion and stiffness cues for YAP Activation in Cellular Collectives

Valeriia Grudtsyna, Vinay Swaminathan, Amin Doostmohammadi

The regulation of mechanotransduction is crucial for various cellular processes, including stem cell differentiation, wound healing, and cancer progression. While the activation of mechanotransduction has been extensively studied in single cells, it remains unclear whether similar mechanisms extend to mechanotransduction in multicellular …

se (code pays fourni par la source)

A spectrum of p-atic symmetries and defects in confluent epithelia

Lea Happel, Griseldis Oberschelp, Gwenda Roselene Rode, Valeriia Grudtsyna et autres

Topological defects provide a unifying language to describe how orientational order breaks down in active and living matter. Considering cells as elongated particles confluent, epithelial tissues can be interpreted as nematic fields and its defects have been linked to extrusion, migration, and …

Bridging cellular responses with collective properties in epithelial monolayers.

Valeriia Grudtsyna