Tianxiang Ma

A principal-stress rule for cell division in epithelia

Lucas Anger, Tianxiang Ma, Fanny Wodrascka, Andreas Schoenit et autres

Abstract Dense active materials must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, where, according to Hertwig’s century-old rule, cells divide along their long axis. …

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Higher-Order Mechanical Neighbourhood Sensing Governs Cell Fate in Complex Tissues

Alphy John, Tianxiang Ma, Duncan J. D. Mackay, Elizabeth C Connolly et autres

Abstract Adult tissues maintain precise architectures composed of multiple interspersed cell types, yet prevailing models of cell fate patterning rely on pairwise interactions between neighbouring cells that generate binary decisions. How local interactions encode higher-order, beyond pairwise, multicellular organization remains unclear. Here, …

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Cell division sets a universal flow geometry in cell layers

Tianxiang Ma, Lasse Bonn, Valeriia Grudtsyna, Nigar Abbasova et autres

Collective flows in epithelial tissues contain a geometric backbone of vortical interfaces whose statistics exhibit hallmarks of critical percolation and conformal invariance. Yet how fundamental cellular processes govern the breakdown of such symmetry-rich flow geometry remains unclear. Here we show that cell …

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A principal-stress rule for cell division in epithelia

Lucas Anger, Tianxiang Ma, Fanny Wodrascka, Andreas Schoenit et autres

Abstract Dense active materials, from cellular tissues to jammed and glassy systems, must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, yet what sets the …

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Mechanical Tension Actively Triggers RhoA-Mediated Cell Extrusion

Fanny Wodrascka, Tianxiang Ma, Pablo Gottheil, Robin Durand et autres

Abstract Cell extrusion is a fundamental process in tissue homeostasis, morphogenesis, and cancer progression, facilitating the removal of cells either alive or through apoptosis. While biochemical signaling pathways are known to regulate extrusion, recent advances have underscored the importance of mechanical forces …

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Emotion-Cause Pair Extraction in Conversations via Semantic Decoupling and Graph Alignment

Tianxiang Ma, Weijie Feng, Xinyu Wang, Zhiyong Cheng

Emotion-Cause Pair Extraction in Conversations (ECPEC) aims to identify the set of causal relations between emotion utterances and their triggering causes within a dialogue. Most existing approaches formulate ECPEC as an independent pairwise classification task, overlooking the distinct semantics of emotion diffusion …

Emotion–Cause Pair Extraction in Conversations via Semantic Decoupling and Alignment

Tianxiang Ma, Weijie Feng, Xinyu Wang, Zhiyong Cheng

Emotion-Cause Pair Extraction in Conversations (ECPEC) aims to identify the set of causal relations between emotion utterances and their triggering causes within a dialogue.Most existing approaches formulate ECPEC as an independent pairwise classification task, overlooking the distinct semantics of emotion diffusion and …

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Cellular Flow Architecture Exposes the Hidden Mechanics of Biological Matter

Tianxiang Ma, Valeriia Grudtsyna, Robin V. Bölsterli, Amin Doostmohammadi

Understanding how biomechanical reorganization governs key biological processes, such as morphogenesis and development, requires predictive insights into stress distributions and cellular behavior. While traditional approaches focused on cell motion as a response to stress, we demonstrate that Lagrangian coherent structures (LCSs)—robust attractors …

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Tunable enhancement of two-color-driven high-order harmonics from a gaseous medium

Zhi-Hong Jiao, Tianxiang Ma, Jin-Xu Du, Guo-Li Wang et autres

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Anti-hyperuniform critical states of active topological defects

Simon Guldager Andersen, Tianxiang Ma, Makito Fredskild Katsume, Martin Cramer Pedersen et autres

Topological defects are fundamental to the collective dynamics of non-equilibrium systems and in active matter, mediating spontaneous flows, dynamic self-organization, and emergent pattern formation. Here, we reveal critical states in active nematics, marked by slowed defect density relaxation, amplified fluctuations, and heightened …

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Differential Elasticity Affects Lineage Segregation of Embryonic Stem Cells

Christine M. Ritter, Tianxiang Ma, Natascha Leijnse, Younes Farhangi Barooji et autres

The question of what guides lineage segregation is central to development, where cellular differentiation leads to segregated cell populations destined for specialized functions. Here, using optical tweezers measurements of mouse embryonic stem cells, we reveal a mechanical mechanism based on differential elasticity …

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Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study

Siting Li, Shiyi Yang, Xiaoning Sun, Tianxiang Ma et autres

Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four AAA patients with …

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