Marta Szydlowska

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

Xin Li, Cynthia Lebeaupin, Aikaterini Kadianaki, Clementine Druelle-Cedano et autres

Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies 1 . Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains …

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Discovery of a Highly Potent and Selective Small-Molecule Inhibitor of In Vivo Anaerobic Choline Metabolism by Human Gut Bacteria

Mariell Pettersson, Giuseppina La Sala, Anders Gunnarsson, Anna Vildhede et autres

Trimethylamine (TMA) Lyase is an enzyme expressed in human gut bacteria that plays a pivotal role in the formation of trimethylamine oxide (TMAO), a metabolite implicated in the development of heart failure. Here, we describe a strategy to design covalent inhibitors targeting …

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Titre indisponible

Paweł Kurzelowski, Monika Kalicka, Maciej Pluskiewicz, Jonasz Osiecki et autres

Internal medicine patients exhibit profound clinical heterogeneity, making length of stay (LOS) prediction challenging. Traditional risk-stratification models relying on static demographic or diagnostic data frequently fail to capture a patient’s real-time homeostatic resilience and dynamic intrahospital physiological fluctuations. Aim To discover latent …

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A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Anne T. Schneider, Christiane Koppe, Émilie Crouchet, Aristeidis Papargyriou et autres

KRAS-dependent acinar-to-ductal metaplasia (ADM) is a fundamental step in the development of pancreatic ductal adenocarcinoma (PDAC), but the involvement of cell death pathways remains unclear. Here, we show that key regulators of programmed cell death (PCD) become upregulated during KRAS-driven ADM, thereby …

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FMC reduced circulating TMAO levels and improved cardiac function without altering the gut microbiome

Ginger Lasky, Yannick Morias, Scott Turick, Ben Sparklin et autres

Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH

Marta Szydlowska, Ginger Lasky, Stephanie Oldham, Cristian Rivera et autres

AIMS: To determine if changes in polyamines metabolism occur during non-alcoholic steatohepatitis (NASH) in human patients and mice, as well as to assess systemic and liver-specific effects of spermidine administration into mice suffering from advanced NASH. MATERIALS AND METHODS: Human fecal samples …

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Exploring the effects of different bile acids receptor agonists in Non-Alcoholic Steatohepatitis (NASH) and NASH-related hepatocarcinogenesis

Enrico Focaccia, Marta Szydlowska, Diran Herebıan, Lukas Amann et autres

Non-Alcoholic Fatty Liver Disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and presents as a condition with progressive severity. Non-Alcoholic Steatohepatitis (NASH) consists in its most detrimental stage, preceding liver cirrhosis, and is an independent risk factor for developing Hepatocellular …

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Resident macrophages of the lung and liver: The guardians of our tissues

Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska

Resident macrophages play a unique role in the maintenance of tissue function. As phagocytes, they are an essential first line defenders against pathogens and much of the initial characterization of these cells was focused on their interaction with viral and bacterial pathogens. …

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Abstract 334: Gut Microbiome Derived Trimethyl-n-oxide Exacerbates Inflammation And Induces Cardiac Fibrosis In Human Cardiac Fibroblasts And In Rodent Model Of Cardiorenal Disease

Minal B. Mehta, Benji Gill, Marta Szydlowska, Guo Liang et autres

Trimethlyamine N-oxide (TMAO), a gut-microbiome derived metabolite of dietary choline and other trimethylamine containing nutrients, has been consistently associated with poor prognosis with cardiovascular diseases (CVD) in recent years. Clinical studies have demonstrated that systemic circulating TMAO levels are independently associated with …

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Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska et autres

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Exploring liver-associated microbes: Who are they and how did they get there?

Jada C. Domingue, Michelle A. Wiebe, Virginia Takahashi, Ginger Lasky et autres

The therapeutic landscape of hepatocellular carcinoma

Suchira Gallage, María García‐Beccaria, Marta Szydlowska, Mohammad Rahbari et autres

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