Mohsen Malehmir

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors

Marc A. Schwartz, Dillon Lue, Mohammed Mutaher, Miriam McNerney et autres

Abstract Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade. We systematically identified regulators of this cell state using genome-wide CRISPR screens in primary T cells in vitro . Using random barcodes to link clonal relationships with guide …

us, es (code pays fourni par la source)

Chemokines that govern T cell activity in tumors

Thorsten R. Mempel, Mohsen Malehmir

us (code pays fourni par la source)

Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska et autres

ch, de, ca, nl, gb, es, us, au (code pays fourni par la source)

Evolution of delayed resistance to immunotherapy in a melanoma responder

David Liu, Jia‐Ren Lin, Emily Robitschek, Gyulnara G. Kasumova et autres

us (code pays fourni par la source)

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Jennifer A. Lo, Masayoshi Kawakubo, Vikram R. Juneja, Mack Y. Su et autres

T cell populations specific for melanocyte antigens was observed only in patients who responded to anti-PD-1 therapy, suggesting that ICI can promote breakdown of tolerance toward tumor-lineage self-antigens. In a mouse model of poorly immunogenic melanomas, spreading of epitope recognition toward wild-type …

us, gb, ch, hu (code pays fourni par la source)

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

Marc E. Healy, Yannick Boege, Michael C. Hodder, Friederike Böhm et autres

Background & Aims Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal epithelial cell (IEC) death and proliferation. While the disruption of several IEC death regulating factors result in intestinal inflammation, the loss of the anti-apoptotic BCL2 family members BCL2 …

ch, gb, de, ca (code pays fourni par la source)

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska et autres

ch, de, ca, nl, gb, es, us, au (code pays fourni par la source)

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska et autres

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet-number, platelet-activation and platelet-aggregation are increased in murine/human NASH, but not in steatosis or steatotic, insulin resistance. Antiplatelet therapy …

ch, de, ca, nl, es, us (code pays fourni par la source)

06: Visualization of hepatitis E virus RNA and proteins in the human liver

Daniela Lenggenhager, Jérôme Gouttenoire, Mohsen Malehmir, Marion Bawohl et autres

Although hepatitis E constitutes a substantial disease burden worldwide, surprisingly little is known about the localization of hepatitis E virus (HEV) in the human liver. We therefore aimed to visualize HEV RNA and proteins in situ.

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

Yannick Boege, Mohsen Malehmir, Marc E. Healy, Kira Bettermann et autres

Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are …

ch, de, gb, be, il, us (code pays fourni par la source)

Visualization of hepatitis E virus RNA and proteins in the human liver

Daniela Lenggenhager, Jérôme Gouttenoire, Mohsen Malehmir, Marion Bawohl et autres

ch (code pays fourni par la source)

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Brian Finan, Christoffer Clemmensen, Zhimeng Zhu, Kerstin Stemmer et autres

de, us, fr, ch, dk, nl (code pays fourni par la source)